Results 81 to 90 of about 27,380 (228)

Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis [PDF]

, 2006
The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation.
Aiga, Ayako, Asaumi, Koji, Kadota, Hiroaki, Lee, You Jin, Mitani, Shigeru, Ozaki, Toshifumi, Takigawa, Masaharu   +6 more
core   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

PLoS ONE, 2019
In the brain, the TrkA receptor for Nerve Growth Factor (NGF) is expressed primarily in the cholinergic system. TrkA/NGF support neuronal health and function, and deficiencies in this axis are associated with progressive cholinergic neuron atrophy and ...
Sylvia Josephy-Hernandez, Iulia Pirvulescu, Mario Maira, Tahar Aboulkassim, Tak Pan Wong, R Anne McKinney, H Uri Saragovi   +6 more
doaj   +1 more source

Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer [PDF]

, 2016
The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate ...
Biordi, Leda, Colapietro, Alessandro, Festuccia, Claudio, Ficorella, Corrado, Gravina, Giovanni Luca, Jitariuc, Ana, Mancini, Andrea, Marampon, Francesco, Sanità, Patrizia, Scarsella, Luca   +9 more
core   +2 more sources

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Ligand signature in the membrane dynamics of single TrkA receptor molecules [PDF]

Journal of Cell Science, 2013
Summary The neurotrophin receptor TrkA (also known as NTRK1) is known to be crucially involved in several physio-pathological processes. However, a clear description of the early steps of ligand-induced TrkA responses at the cell plasma membrane is missing.
Laura Marchetti1, 2, Andrea Callegari1, Stefano Luin1, Giovanni Signore3, Alessandro Viegi2, Fabio Beltram1, 3, Antonino Cattaneo2   +8 more
openaire   +3 more sources

Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat

European Journal of Histochemistry, 2009
Nerve Growth Factor (NGF) is a member of the neurotrophin family. Neurotrophins exert their effects by binding to corresponding receptors, which are formed by the tyrosine protein kinases TrkA, TrkB, and TrkC, and the low affinity p75NTR receptor.
C. Squillacioti, A. De Luca, S. Paino, E. Langella, N. Mirabella   +4 more
doaj   +3 more sources

Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation [PDF]

, 2017
Optimization of ligand binding affinity to the target protein of interest is a primary objective in small-molecule drug discovery. Until now, the prediction of binding affinities by computational methods has not been widely applied in the drug discovery ...
Bagal, SK, Bhati, AP, Coveney, PV, Omoto, K, Shanmugasundaram, V, Skerratt, S, Wan, S   +6 more
core   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2014
The nerve growth factor (NGF) pathway has been shown to play a key role in pain treatment. Recently, a systems pharmacology model has been proposed that can aid in the identification and validation of drug targets in the NGF pathway. However, this model did not include the role of the p75 receptor, which modulates the signaling of NGF through the ...
Toni, T, Dua, P, van der Graaf, P H
openaire   +2 more sources