Results 91 to 100 of about 1,251,047 (226)

Imidazoline receptor antisera-selected protein: a unique modulator of neuronal differentiation. [PDF]

, 2008
The imidazoline I1 receptor (I1-R) is a novel receptor found primarily in the brain and nervous tissue where it modulates neurotransmission. It is named for its high affinity for compounds with an imidazoline structure such as the anti-hypertensive drugs,
Dehle, Francis Christian
core  

A temporal (phospho-)proteomic dataset of neurotrophic receptor tyrosine kinase signalling in neuroblastoma

Scientific Data
Neurotrophic receptor tyrosine kinases (TrkA, TrkB, TrkC), despite their homology, contribute to the clinical heterogeneity of the childhood cancer neuroblastoma.
Stephanie Maher, Kieran Wynne, Vadim Zhernovkov, Melinda Halasz   +3 more
doaj   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

Cell Reports, 2016
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The
Damir Omerbašić, Ewan St. J. Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Chris G. Faulkes, Matthias Selbach, Gary R. Lewin   +9 more
doaj   +1 more source

Purinergic Receptor P2Y2 Regulates Neurogenesis and Functional Recovery Following Spinal Cord Injury in Zebrafish

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Although purinergic P2Y2 receptor can regulate neural stem cell (NSC) proliferation and neurogenesis in mammals, it is downregulated following spinal cord injury (SCI). It was previously unknown whether this receptor regulates these processes in the more‐regenerative zebrafish model, where the contribution of these responses allows near‐complete ...
Isaac J. Sullivan, Eva E. Stefanova, Mavis C. Chinn, Thomas A. Burke, Bradley G. Fitzgerald, Matthew T. Sorbara, Terence J. Van Raay, Angela L. Scott   +7 more
wiley   +1 more source

A De Novo Peptide That Induces Axonal Growth Through TrkB Activation

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A homodimeric anti‐TrkB macrocyclic peptide, DiTrbL3, originally discovered by the RaPID system as monomeric form, dimerizes the TrkB receptor and activate the downstream signaling. DiTrbL3 acts as a mimic of BDNF (the natural protein ligand) and stimulates hippocampal neurons to extend axons.
Rumit Maini, Kota Tamada, Kunihiro Fukuda, Toru Takumi, Hiroaki Suga   +4 more
wiley   +1 more source

In vitro effect of nerve growth factor on the main traits of rabbit sperm

Reproductive Biology and Endocrinology, 2019
Background The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role not only in the nervous but also in other non-nervous systems such as the reproductive system. The aim of the paper is to study the in vitro effect of
Cesare Castellini, Simona Mattioli, Alessandro Dal Bosco, Giulia Collodel, Alessandra Pistilli, Anna Maria Stabile, Lara Macchioni, Francesca Mancuso, Giovanni Luca, Mario Rende   +9 more
doaj   +1 more source

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei, Xiaoyu Hu, Ruida Lu, Jian‐jun Yang, Qingsheng Meng   +4 more
wiley   +1 more source

Estrogenic effects on TrkA receptor signalling

, 2014
The steroid hormone estrogen has wide spread physiological actions on many cell-types including neurons and neuroendocrine cells. The signalling mechanisms are mediated by a number of distinct receptor subtypes including estrogen receptor alpha, estrogen
Matsas, Marc Caleb
core  

The Chagas' Disease Parasite Trypanosoma cruzi Exploits Nerve Growth Factor Receptor TrkA to Infect Mammalian Hosts [PDF]

, 2007
SummaryTrypanosoma cruzi, the agent of Chagas' disease, is an obligate intracellular parasite that invades various organs including several cell types in the nervous system that express the Trk receptor tyrosine kinase.
PereiraPerrin, Mercio, de Melo-Jorge, Milena   +1 more
core   +1 more source