Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging
Pharmaceuticals, 2019 The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher +17 more
doaj +1 more source
A Spaetzle-like role for Nerve Growth Factor β in vertebrate immunity to Staphylococcus aureus [PDF]
, 2014 Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent.
Antrobus, R +31 more
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Connective tissue growth factor is a new ligand of epidermal growth factor receptor [PDF]
, 2013 Chronic kidney disease is reaching epidemic proportions worldwide and there is no effective treatment. Connective tissue growth factor (CCN2) has been suggested as a risk biomarker and a potential therapeutic target for renal diseases, but its specific ...
Abreu +56 more
core +1 more source
, 2004 Current all-atom potential based molecular dynamics (MD) allow the identification of a protein's functional motions on a wide-range of time-scales, up to few tens of ns.
Carloni, Paolo +2 more
core +1 more source
The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]
, 2017 The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J. +4 more
core +2 more sources
TrkA receptors delay C6-2B glioma cell growth in rat striatum
Molecular Brain Research, 1998 Nerve growth factor (NGF) acts as an anti-mitogenic factor in C6-2B glioma cells stably expressing TrkA (C6trk+). To study the effect of TrkA on cell growth in vivo, we grafted mock and C6trk+ cells into the striatum of ACI nude rats. Thy 1.1 and p75NTR immunohistochemistry revealed that wild type C6-2B cells formed a tumor mass in the striatum by 14 ...
S J, Rabin +4 more
openaire +2 more sources
Functional Diversity of Neurotrophin Actions on the Oculomotor System [PDF]
, 2016 Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes.
Benítez Temiño, Beatriz +5 more
core +1 more source
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study [PDF]
, 2016 BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB,
Agung Dewanto +6 more
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TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors [PDF]
, 1906 SummaryPrimary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits ...
Wheeler, Michael A. +6 more
core +1 more source
Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action. [PDF]
, 2001 Cell death in the developing retina is regulated, but so far little is known about what factors regulate the cell death. Several neurotrophic factors and receptors, including the neurotrophins and Trk receptors, are expressed during the critical time. We
Catsicas, S +5 more
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