Results 121 to 130 of about 27,380 (228)
Neuroprotektion und Aktivierung von Neurotrophin-Signaltransduktionswegen durch Hemmung von Protein-Tyrosin-Phosphatasen und durch NO-Donatoren [PDF]
, 2004 Trotz des enormen Fortschrittes der Medizin und neuen Erkenntnissen über die pathologischen Mechanismen des neuronalen Zelltodes steht bislang keine wirkungsvolle, kausale Therapie zur Behandlung neurodegenerativer Erkrankungen zur ...
Gerling, Norbert +1 more
core +1 more source
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons [PDF]
, 2010 Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity.
Davis López de Carrizosa, María América +4 more
core +1 more source
Neural Regeneration Research, 2016 Delayed ischemic neurologic deficit after subarachnoid hemorrhage results from loss of neural cells. Nerve growth factor and its receptor TrkA may promote regeneration of neural cells, but their expression after subarachnoid hemorrhage remains unclear ...
Jin-ning Song +6 more
doaj +1 more source
Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas [PDF]
, 2009 The immunohistochemical profile of neurotrophins and their receptors in the human cranial dura mater was studied by examining certain dural zones in specimens harvested from different regions (frontal, temporal, parietal and occipital).
Alicino, V +9 more
core +1 more source
Tissue-specific alternative splicing generates two isoforms of the trkA receptor
Journal of Biological Chemistry, 1993 The trkA receptor functions as a signal transducing receptor for nerve growth factor. In this report, we show that alternative splicing results in the production of two distinct trkA isoforms in both rats and humans. These isoforms differ by virtue of a 6-amino acid insertion in their extracellular domain, the placement of which corresponds exactly ...
P A, Barker +5 more
openaire +2 more sources
Scientific Reports, 2018 Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the ...
Sally L. Elshaer, Azza B. El-Remessy
doaj +1 more source
The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
Journal of Experimental & Clinical Cancer Research, 2018 Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and childhood cancers driven by novel oncogenic TrkA ...
Antonietta Rosella Farina +6 more
doaj +1 more source
Enhancement of HGF-induced tubulogenesis by endothelial cell-derived GDNF [PDF]
, 2019 学位記番号 ...
Nakasatomi, Masao +2 more
core
Mast cell activation by NGF drives the formation of trauma-induced heterotopic ossification
JCI InsightSoft tissue trauma can cause immune system disturbance and neuropathological invasion, resulting in heterotopic ossification (HO) due to aberrant chondrogenic differentiation of mesenchymal stem cells (MSCs).
Tao Jiang +11 more
doaj +1 more source
Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases
PharmaceuticalsMany routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases.
George N. Chaldakov +8 more
doaj +1 more source