Results 101 to 110 of about 1,251,047 (226)

Low Affinity NGF Receptor (p75 Neurotrophin Receptor) Inhibit Sensory Nerve Growth in Human Degenerative Nucleus Pulposus Cells

Global Spine Journal, 2014
Introduction Degeneration of the lumbar intervertebral disc is a cause of low back pain. The pathological mechanism is thought to be sensory nerve ingrowth into the inner layers of the degenerated intervertebral disc.
K. Yamauchi, S. Orita, Y. Sakuma, Y. Oikawa, G. Kubota, K. Inage, T. Saino, J. Sainoh, K. Fujimoto, Y. Eguchi, M. Suzuki, K. Takahashi, S. Ohtori   +12 more
doaj   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

Isoformas del receptor TRKA y su relación con ADAM17 en el cáncer ovárico epitelial [PDF]

, 2011
El receptor de alta afinidad de la neurotrofina NGF, TRKA, ha sido asociado con distintos tipos de cáncer, pudiendo encontrarse isoformas de este receptor. En el cáncer ovárico no se han descrito isoformas de este receptor, sin embargo, se ha determinado
Girardi Silva, Silvanna Andrea
core  

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source

Nerve Growth Factor Receptor TrkA Exists as a Preformed, yet Inactive, Dimer in Living Cells [PDF]

, 2010
The tropomyosin-related kinase A (TrkA) receptor and its ligand, nerve growth factor (NGF), play crucial roles in the development and function of the nervous system.
Maruyama, Ichiro N., Ichiro N. Maruyama, Maruyama, Ichiro, Jianying Shen, Shen, Jianying   +4 more
core   +1 more source

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier   +17 more
doaj   +1 more source

Addressing Overlooked Variables in Preclinical Fracture Repair Research for Improved Translation

Journal of Orthopaedic Research, Volume 44, Issue 9, September 2026.
ABSTRACT In preclinical research focused on bone fracture repair, a significant gap exists in understanding and incorporating key variables that influence homeostasis and pathophysiological processes. Factors such as immune system responses, sex differences, pain and innervation, and microbiota are often overlooked.
Christina Capobianco, Katharina Schmidt‐Bleek, Melanie Haffner‐Luntzer, Chelsea Bahney, Joseph L. Roberts, Matthew J. Silva, Annemarie Lang   +6 more
wiley   +1 more source

TrkA COOH-terminal tail: its relevance on receptor stability and signaling for cell differentiation and survival [PDF]

, 2010
El receptor del factor de creixement nerviós TrkA contribueix a la supervivència i a ladiferenciació de diferents poblacions neuronals. Tot i que les principals vies de senyalització imolècules adaptadores activades després de la unió del lligant al ...
Maya Vladkova, Georgieva
core  

Structural and dynamical properties of central nervous system proteins with pharmaceutical and biotechnological potential. [PDF]

, 2010
Neurodegenerative diseases are widespread pathologies of large social impact that include: prion, Alzheimer and Parkinson disease, Huntington chorea and amyotrophic lateral sclerosis.
Stanzione, Francesca
core   +1 more source

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source