Results 101 to 110 of about 27,380 (228)
Chemistry & Biology, 2009 Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation.
Jang, Sung Wuk +6 more
openaire +4 more sources
Scientific DataNeurotrophic receptor tyrosine kinases (TrkA, TrkB, TrkC), despite their homology, contribute to the clinical heterogeneity of the childhood cancer neuroblastoma.
Stephanie Maher +3 more
doaj +1 more source
NGF – the TrkA to successful pain treatment [PDF]
, 2012 Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment.
Kumar, Vinayak, Mahal, Brandon
core +1 more source
Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries
Advanced Science, Volume 13, Issue 23, 23 April 2026.Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao +5 more
wiley +1 more source
In vitro effect of nerve growth factor on the main traits of rabbit sperm
Reproductive Biology and Endocrinology, 2019 Background The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role not only in the nervous but also in other non-nervous systems such as the reproductive system. The aim of the paper is to study the in vitro effect of
Cesare Castellini +9 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 4, April 2026.This Mendelian randomization study reveals that normal pressure hydrocephalus (NPH) causally leads to lower levels of the neurotrophins CNTF and GDNF. This finding provides new genetic evidence for the role of neurotrophic factors in NPH, suggesting potential avenues for further research into prevention and treatment strategies.
Tao Xu +4 more
wiley +1 more source
Global Spine Journal, 2014 Introduction Degeneration of the lumbar intervertebral disc is a cause of low back pain. The pathological mechanism is thought to be sensory nerve ingrowth into the inner layers of the degenerated intervertebral disc.
K. Yamauchi +12 more
doaj +1 more source
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis [PDF]
, 2011 Background Nerve growth factor (NGF) is a potent growth factor that plays a key role in neuronal cell differentiation and may also play a role in hematopoietic differentiation.
Priyanka Dutta +6 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao +8 more
wiley +1 more source