Results 51 to 60 of about 27,380 (228)

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation [PDF]

Glycobiology, 2004
Trypanosome trans-sialidase (TS) is a sialic acid-transferring enzyme that hydrolyzes alpha2,3-linked sialic acids and transfers them to acceptor molecules. Here we show that a highly purified recombinant TS derived from T. cruzi parasites targets TrkA receptors on TrkA-expressing PC12 cells and colocalizes with TrkA internalization and phosphorylation
Alicja, Woronowicz, Kristof, De Vusser, Wouter, Laroy, Roland, Contreras, Susan O, Meakin, Gregory M, Ross, Myron R, Szewczuk   +6 more
openaire   +2 more sources

TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK+ T‐cell lymphoma

Molecular Oncology, 2017
Nucleophosmin‐anaplastic lymphoma kinase‐expressing (NPM‐ALK+) T‐cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM‐ALK+ T‐cell lymphoma is not completely understood.
Wenyu Shi, Suraj Konnath George, Bhawana George, Choladda V. Curry, Albina Murzabdillaeva, Serhan Alkan, Hesham M. Amin   +6 more
doaj   +1 more source

Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice

iScience, 2023
Summary: In mature bone, NGF is produced by osteoblasts following mechanical loading and signals through resident sensory nerves expressing its high affinity receptor, neurotrophic tyrosine kinase receptor type 1 (TrkA), to support bone formation.
Ibtesam Rajpar, Gaurav Kumar, Paolo Fortina, Ryan E. Tomlinson   +3 more
doaj   +1 more source

A Spaetzle-like role for nerve growth factor beta in vertebrate immunity to Staphylococcus aureus [PDF]

, 2014
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent.
A. Kaser, Addis, Aloe, Aranda, Ashburner, B. Ochoa, B. Surewaard, Belvin, Bischoff, C. A. Loynes, C. Bryant, C. G. Woods, C. Klapholz, Carnesecchi, Chamy, Chen, Cohen, D. M. Grogono, de Tayrac, Floto, Floto, Guo, G  mez, Hoffmann, Howe, J. Cachat, J. Connolly, K. Brown, K. Hegyi, K. L. Hammond, Kwan, L. Hepburn, L. Minichiello, L. Wang, Lemaitre, Lowy, M. E. Torok, M. Holden, M. Otto, M. Schiebler, Mizuguchi, Murzin, N. V. Ogryzko, Needham, Novick, Otten, P. Ligoxygakis, P. Moreno, Paradis, Peschon, Prajsnar, Prajsnar, R. A. Floto, R. Antrobus, Renna, Rice, Rigby, Rotthier, S. A. Renshaw, S. J. Foster, S. J. Peacock, S. L. Seneviratne, Seidah, Shi, Sofroniew, Stuart, Surewaard, T. Blundell, T. K. Prajsnar, T. Ny, Thwaites, Valanne, Vitt, Weber, Wu, Zhu   +75 more
core   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA. [PDF]

PLoS ONE, 2013
Cardiomyocytes express neurotrophin receptor TrkA that promotes survival following nerve growth factor (NGF) ligation. Whether TrkA also resides in cardiac fibroblasts (CFs) and underlies cardioprotection is unknown.To test whether CFs express TrkA that ...
Daniel Aridgides, Ryan Salvador, Mercio PereiraPerrin   +2 more
doaj   +1 more source

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
AlQatari, M, Ernfors, P, Hjerling-Leffler, J, Koltzenburg, M   +3 more
core   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources