Results 121 to 130 of about 2,911,119 (244)

Fyn-Mediated Regulation of Protein Kinase A [PDF]

, 2017
Protein kinases are enzymes important for signal transduction in the regulation of cellular processes. The cAMP-dependent protein kinase A (PKA) has been previously reported to regulate the activity of the Src family kinase Fyn, an event important for ...
Barritt, Sam
core   +1 more source

The Role of Neuro‐Immune Regulation in the Pathogenesis of Psoriasis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic ...
Xin Liu, Mingyu Yu, Pan Zou, Suwen Liu, Jian Jiang, Liyang Ge, Su Jiang, Jingyu Zhang, Xin Wang, Hongxiang Chen, Poorani Gurumallesh Prabu   +10 more
wiley   +1 more source

The ErbB2 receptor in gastric cancer. the quick-change artist [PDF]

, 2015
The ErbB family of receptors is providing the oncogenic signals necessary to cells to become transformed. In gastric cancer (GC) the ErbB2 (HER2) expression is associated with a poor prognosis, but addition of ErbB-targeted therapeutics to chemotherapy ...
Alimandi, Maurizio, D'Aloia, MARIA MICHELA, Malaguti, Paola   +2 more
core   +1 more source

TRK inhibitors: managing on-target toxicities [PDF]

Annals of Oncology, 2020
J S J, Lim, D S P, Tan
openaire   +2 more sources

The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases

Frontiers in Oncology
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors.
Philippe Metellus, Philippe Metellus, Clara Camilla, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Pascale Tomasini, Manmeet S. Ahluwalia, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik, L’Houcine Ouafik   +15 more
doaj   +1 more source

NTRK1-rearranged histiocytosis: clinicopathologic and molecular features

Blood Advances
: Non-Langerhans cell histiocytoses are a diverse group of histiocytic diseases. Different entities are defined based on clinical, histopathologic, and/or molecular characteristics. This study aimed to define NTRK-rearranged histiocytosis.
Rivers Fragneau, Sylvie Fraitag, Paul G. Kemps, Zofia Hélias-Rodzewicz, Somak Roy, Benjamin Bonsang, Allison L. Bartlett, Subhra Dhar, Martin Jankofsky, Jozef Zlocha, Karel Svojgr, Lenka Krsková, Andrica C. H. de Vries, Robert M. Verdijk, Jan A. M. van Laar, Roos J. Leguit, Philippe Drabent, Eric D. Carlsen, Jonhan Ho, Arivarasan D. Karunamurthy, Mariarita Santi, Marie-Laure Jullié, Florian Babor, Robert Lorsbach, Astrid G. S. van Halteren, Sébastien Héritier, Eli L. Diamond, Benjamin H. Durham, Ashish R. Kumar, Arunaloke Bhattacharya, Julien Haroche, Jean Donadieu, Arndt Borkhardt, Jennifer L. Picarsic, Jean-François Emile   +34 more
doaj   +1 more source

Valutazione dei livelli di BDNF ematico in uno studio di follow-up su pazienti con depressione maggiore [PDF]

, 2005
Il fattore neurotrofico cervello-derivato (BDNF) è, tra i membri della famiglia delle neurotrofine, quello che mostra l'espressione più diffusa nel cervello del mammifero adulto e in fase di sviluppo.
Scatena, Alessia
core  

A Modified Chinese Herbal Decoction (Kai-Xin-San) Promotes NGF-Induced Neuronal Differentiation in PC12 Cells via Up-Regulating Trk A Signaling

Frontiers in Cell and Developmental Biology, 2017
Kai-Xin-San (KXS), a Chinese herbal decoction, has been applied to medical care of depression for thousands of years. It is composed of two functional paired-herbs: Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR ...
Lu Yan, Lu Yan, Lu Yan, Lu Yan, Min Wei, Min Wei, Amy G. Gong, Amy G. Gong, Pingping Song, Pingping Song, Jianshu Lou, Jianshu Lou, Cathy W. Bi, Cathy W. Bi, Sherry L. Xu, Aizhen Xiong, Tina T. Dong, Tina T. Dong, Karl W. Tsim, Karl W. Tsim   +19 more
doaj   +1 more source

Phase 1 dose escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer-Lack of association between activating AKT mutation and AKT inhibition-derived efficacy [PDF]

, 2019
This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced ...
Boix, Oliver, Hess, Dagmar, Hurvitz, Sara A, Joerger, Markus, Lagkadinou, Eleni, Ma, Cynthia, Moulder, Stacy, Ocker, Matthias, Rentzsch, Christine, Rudolph, Marion, Schneeweiss, Andreas, Thiele, Silke, Tsimberidou, Apostolia M, Varga, Andrea, Wilkinson, Gary   +14 more
core   +3 more sources

Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers

Molecular Brain, 2009
Mossy fibers, the dentate granule cell axons, are generated throughout an animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the stratum lucidum within the CA3 region.
Tamura Makoto, Tamura Naohiro, Ikeda Takamitsu, Koyama Ryuta, Ikegaya Yuji, Matsuki Norio, Yamada Maki K   +6 more
doaj   +1 more source