Results 91 to 100 of about 657,649 (153)

Precision oncology using organoids of a secretory carcinoma of the salivary gland treated with TRK-inhibitors. [PDF]

Oral Oncol, 2023
Lassche G, van Engen-van Grunsven ACH, van Hooij O, Aalders TW, Am Weijers J, Cocco E, Drilon A, Hoischen A, Neveling K, Schalken JA, Verhaegh GW, van Herpen CML.   +11 more
europepmc   +1 more source

Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease.

, 2000
The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity.
Savaskan E, Olivieri G, Rosenberg C, Hock C, Bruttel S, Otten U, Hulette C, Müller-Spahn F   +7 more
core   +1 more source

The promise of TRK inhibitors in pediatric cancers with NTRK fusions. [PDF]

Cancer Genet, 2022
Blauel ER, Laetsch TW.
europepmc   +1 more source

Secretory carcinoma of major and minor salivary glands with ETV6-NTRK3 gene fusion: overcoming misdiagnosis in the era of tumour-agnostic therapy with TRK inhibitors. [PDF]

Contemp Oncol (Pozn), 2023
Durzyńska M, Dominiak K, Sosnowska I, Michalek IM.   +3 more
europepmc   +1 more source

Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer

, 2019
Introduction: Detecting oncogenic drivers across multiple cancers has brought about a shift toward a more targeted therapeutic approach. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are genomic rearrangements containing the kinase domain of ...
Noah Federman (799643), Ray McDermott (112352)   +1 more
core   +1 more source

Durable Response in <italic>NTRK</italic> Fusion-Positive Advanced Salivary Gland Tumor: A Case Report

Case Reports in Oncology
Introduction: NTRK fusions lead to the production of constitutively active TRK proteins, which drive oncogenesis in approximately 0.2% of cancers.
George A. Oblitas Alca, Lizet Ayala Loma, Lisde González, Pedro Vega, Yashira L. Negrón Abril, Daniel Sumarriva   +5 more
doaj   +1 more source

Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

, 2016
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound ...
Keith Rickert (1779991), Alicja Krasowska-Zoladek (1779973), Kristen L. G. Jones (1779994), Barbara Hanney (1780003), Christopher Daley (1779979), Edward J. Brnardic (1779985), Shawn J. Stachel (1780000), Ming-Tain Lai (1534570), Vandna Munshi (1779976), Melissa S. Egbertson (1779961), Daniel Riley (1779997), Mark T. Bilodeau (1779970), Peter J. Manley (1780009), Mike T. Rudd (1779988), Yiwei Li (15334), Michael Leitl (1779982), Dennis Murphy (1779949), Darrell A. Henze (1779955), Kausik K. Nanda (1779967), Paul Zuck (1780006), Hua-Poo Su (270730), Ahren Green (1779952), Stephanie A. Kane (1779964), John M. Sanders (1503199), Jay A. Grobler (1779958)   +24 more
core   +1 more source

Recent advances in drug therapy for advanced gastrointestinal stromal tumor

Zhongguo aizheng zazhi, 2021
Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. Tyrosine kinase inhibitors (TKIs) as targeted agents are the backbone for advanced GIST treatment. During the
汪　明, 曹　晖
doaj  

NTRK Gene Fusions in Solid Tumors and TRK Inhibitors: A Systematic Review of Case Reports and Case Series. [PDF]

J Pers Med, 2022
Iannantuono GM, Riondino S, Sganga S, Rosenfeld R, Guerriero S, Carlucci M, Capotondi B, Torino F, Roselli M.   +8 more
europepmc   +1 more source

Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays

, 2011
Neurotrophins are important mediators of neuronal development, survival and plasticity. They act via binding to Trk receptors, which results in the stimulation of the intracellular tyrosine kinase domain of the receptor leading to autophosphorylation of ...
Elliott, Matthew, Natalia Shpiro, Shpiro, Natalia, Traynor, Ryan, Martin, Kirsty J., J. Simon C. Arthur, Arthur, J. Simon C.; id_orcid, Ryan Traynor, Matthew Elliott, Kirsty J. Martin   +9 more
core   +1 more source