Results 1 to 10 of about 2,385,649 (308)
Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers
Acta Pharmaceutica Sinica B, 2021 Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes ...
Tingting Jiang +7 more
doaj +3 more sources
Trk receptor expression and inhibition in neuroblastomas. [PDF]
Clin Cancer Res, 2009 Abstract Neuroblastoma, the most common and deadly solid tumor in children, exhibits heterogeneous clinical behavior, from spontaneous regression to relentless progression. Current evidence suggests that the TRK family of neurotrophin receptors plays a critical role in these diverse behaviors.
Brodeur GM +8 more
europepmc +5 more sources
Case Report: Novel findings of larotrectinib in children with NTRK-rearranged spindle cell tumor [PDF]
Frontiers in OncologyNeurotrophic tropomyosin receptor kinase (NTRK)-rearranged spindle cell tumors are often resistant to chemotherapy and radiotherapy. Fortunately, they are sensitive to targeted therapy of tropomyosin receptor kinase (TRK) inhibitors. However, the data on
Linnan Wu +11 more
doaj +2 more sources
The Genomic and Proteomic Profiles of NTRK Genes and Trk Receptors in Liver Hepatocellular Carcinoma [PDF]
Clinical Medicine Insights: Oncology, 2023 Background: The neurotrophic tyrosine kinase (NTRK) gene family includes NTRK1, NTRK2, and NTRK3, which encode tropomyosin receptor kinases TrkA, TrkB, and TrkC, respectively.
Hejing Wang +4 more
doaj +2 more sources
Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by <i>Gars</i> mutations. [PDF]
Proc Natl Acad Sci U S A, 2017 Sleigh JN +12 more
europepmc +2 more sources
Trk Receptors and Neurotrophin Cross-Interactions: New Perspectives Toward Manipulating Therapeutic Side-Effects [PDF]
Frontiers in Molecular Neuroscience, 2017 Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling.
Yazan Haddad +5 more
doaj +2 more sources
Psychopharmacology, 2023 Major depressive disorder (MDD) is defined as a complex mental disorder which is characterized by a pervasive low mood and aversion to activity. Several types of neurotransmitter systems e.g.
N. Madjid +6 more
semanticscholar +1 more source
TRK Inhibitors: Tissue-Agnostic Anti-Cancer Drugs
Pharmaceuticals, 2021 Recently, two tropomycin receptor kinase (Trk) inhibitors, larotrectinib and entrectinib, have been approved for Trk fusion-positive cancer patients. Clinical trials for larotrectinib and entrectinib were performed with patients selected based on the ...
Sun-Young Han
doaj +1 more source
F1000Research, 2023 Background: NTRK1, NTRK2, and NTRK3 are members of the neurotrophic receptor tyrosine kinases (NTRK) family, which encode TrkA, TrkB, and TrkC receptors, respectively.
Fazil Ahmad +3 more
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Tropomyosin Receptor Kinase Inhibitors for the Treatment of TRK Fusion Cancer
Clinical Cancer Research, 2021 Chromosomal rearrangements of NTRK1–3 resulting in gene fusions (NTRK gene fusions) have been clinically validated as oncogenic drivers in a wide range of human cancers. Typically, NTRK gene fusions involve both inter- and intrachromosomal fusions of the
T. Laetsch, D. Hong
semanticscholar +1 more source