Results 91 to 100 of about 2,286,378 (300)

Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney

Veterinary Sciences, 2022
Neurotrophins and their receptors are involved in the development and maintenance of neuronal populations. Different reports have shown that all neurotrophin/receptor pathways can also play a role in several non-neuronal tissues in vertebrates, including
Pietro Cacialli, Carla Lucini
doaj   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, Volume 6, Issue 4, Page 1987-2010, July 2025.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source

The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration [PDF]

, 2015
NMDA Receptors (NMDA-Rs) are ionotropic glutamate receptors, which associate with LDL Receptor-related Protein-1 (LRP1) to trigger cell-signaling in response to protein ligands in neurons.
Campana, W. Marie, Gonias, Steven L., Lam, Michael S, Mantuano, Elisabetta, Shibayama, Masataka   +4 more
core   +2 more sources

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review discusses the molecular mechanisms through which these compounds inhibit cancer progression, including the induction of reactive oxygen species, inhibition of mitotic kinase and angiogenesis, and suppression of topoisomerase activity. By providing the latest insights on these anti‐tumor agents and their pharmacological actions, our review ...
Ali Ikram, Nasir A. Ibrahim, Muhammad Tayyab Arshad, Abroo Fatima, Ali Asghar Taseer, Mahreen Faqeer Hussain, Zunair Abdullah, Nosiba S. Basher, Muhammed Adem Abdullahi, Ammar AL‐Farga, Mohammed Ali Al‐Duais   +10 more
wiley   +1 more source

Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels [PDF]

, 1998
Heteromultimeric G protein-activated inward rectifier K+ (GIRK) channels, abundant in heart and brain, help to determine the cellular membrane potential as well as the frequency and duration of electrical impulses. The sequence arginine-glycine-aspartate
Dang, Yan L., Davidson, Norman, Lester, Henry A., McPhee, Jancy C.   +3 more
core   +1 more source

The Association Between Recreational Cannabis Use and 24‐hour Movement Behaviours: Perceptions of Youth Citizen Scientists

Journal of Adolescence, Volume 97, Issue 5, Page 1211-1224, July 2025.
ABSTRACT Introduction The prevalence of cannabis use among youth is rising globally, making it crucial to understand its role in health and well‐being. While cannabis use is linked to various health outcomes, evidence on its relationship with 24‐h movement behaviours (moderate‐to‐vigorous physical activity, sedentary behaviour, and sleep) in youth is ...
Tarun Reddy Katapally, Sheriff Tolulope Ibrahim, Jamin Patel   +2 more
wiley   +1 more source

In Silico Design and Verification of LAMP-BDNF Chimeric Protein for Presentation of BDNF on the Surface of Exosomes for Drug Delivery Through Blood-Brain Barrier

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: The mature form of brain-derived neurotrophic factor (BDNF) binds to BDNF/NT-3 growth factors receptor (Trk-B). This binding leads to activation of Ras–MAPK pathway which is integrated with cell growth and proliferation.
Saeed Khalili, Seyedeh Farzaneh Mahdavian, Niloufar Ahmadifard, Reza Valadan, Naghi Shahabi Majd, Hosein Ranjbaran, Mohammad Reza Mahdavi, Atena Sharif Razavi, Shabanali Khodashenas   +8 more
doaj  

A Novel Empirical Autoinduction Model to Characterize the Population Pharmacokinetics and Recommend Dose for Repotrectinib in Adult and Adolescents With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1‐3 Rearrangements

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 7, Page 1179-1190, July 2025.
ABSTRACT Repotrectinib is approved in the US for treating ROS1‐positive non‐small cell lung cancer (NSCLC) and solid tumors harboring an NTRK gene fusion. A Population Pharmacokinetic (PopPK) model for repotrectinib was developed using data from 620 adults (118 healthy volunteers and 502 patients) across seven studies and 24 pediatric patients from one
Shengnan Du, Zheyi Hu, Jun Shen, Lora Hamuro, Justine Lam, Ming Lu, Li Zhu, Amit Roy, Anna Kondic   +8 more
wiley   +1 more source

Trk is a calmodulin‐binding protein: implications for receptor processing

Journal of Neurochemistry, 2003
AbstractThe tyrosine kinase receptors for the neurotrophins (Trk) are a family of transmembrane receptors that regulate the differentiation and survival of different neuronal populations. Neurotrophin binding to Trk leads to the activation of several signalling pathways including a rapid, but moderate, increase in intracellular calcium levels.
Marta Llovera, Mario Encinas, Dionisio Martin-Zanca, Nativitat Rocamora, Yolanda de Pablo, Joaquim Egea, Sandra Peiró, Joan X. Comella   +7 more
openaire   +4 more sources

One at a time, live tracking of NGF axonal transport using quantum dots [PDF]

, 2007
Retrograde axonal transport of nerve growth factor (NGF) signals is critical for the survival, differentiation, and maintenance of peripheral sympathetic and sensory neurons and basal forebrain cholinergic neurons.
A. Ramirez, B. Cui, Beattie, Bhattacharyya, Bomont, Bonneau, Bronfman, C. Wu, Campenot, Chan, Claude, Delcroix, E. L. Bearer, Fu, Giepmans, Ginty, Grimes, Hohng, Howe, Korsching, Kuruvilla, L. Chen, Lidke, Miller, Mobley, Pinaud, Reynolds, Reynolds, Rosenberg, S. Chu, Salehi, Sofroniew, Tani, Taylor, Ure, Valdez, von Bartheld, Vu, W. C. Mobley, W.-P. Li, Watson, Weible, Wu, Ye, Zhuang, Zweifel   +45 more
core   +3 more sources