Results 101 to 110 of about 2,385,649 (308)

Plant‐Derived Viral Nanoparticles Enable Simultaneous Guidance of Neuronal Cell Outgrowth and Targeting of Neurodifferentiation Pathways

Small, Volume 22, Issue 1, 2 January 2026.
A neuronal tissue engineering approach employing plant‐derived viral nanoparticles (VNPs) that have been genetically engineered to display functional peptides is presented. These VNPs simultaneously promote neuronal differentiation and directional growth.
Mira Ritter, Natalija Stojanović, Simon Zschieschang, Johannes Grader, MHD Naeem Assasa, Eva Miriam Buhl, Andrea Coschiera, Stefan Schillberg, Juliane Schuphan, Horst Fischer   +9 more
wiley   +1 more source

Pyrazolo[1,5-a]pyrimidine as a Prominent Framework for Tropomyosin Receptor Kinase (Trk) Inhibitors—Synthetic Strategies and SAR Insights

Molecules
Tropomyosin receptor kinases (Trks) are transmembrane receptor tyrosine kinases named TrkA, TrkB, and TrkC and encoded by the NTRK1, NTRK2, and NTRK3 genes, respectively.
Amol T. Mahajan, Shivani, Ashok Kumar Datusalia, Carmine Coluccini, Paolo Coghi, Sandeep Chaudhary   +5 more
doaj   +1 more source

Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.

PLoS Biology, 2007
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of ...
Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip   +4 more
doaj   +1 more source

Basophil priming by neurotrophic factors. Activation through the trk receptor.

Journal of Immunology, 1996
There is increasing evidence that nerve growth factor (NGF) acts on cells of the immune system, apart from its neurotrophic effects. In human basophils, NGF potentiates mediator release and primes the cells to produce leukotriene C4 in response to C5a ...
Beatrice Burgi, Uwe Otten, B. Ochensberger, S. Rihs, Klaus Heese, P. Ehrhard, Carlos F. Ibáñez, Clemens A. Dahinden   +7 more
semanticscholar   +1 more source

Small molecule activators of the Trk receptors for neuroprotection [PDF]

BMC Neuroscience, 2008
The neurotrophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease.
Webster, Nicholas JG, Pirrung, Michael C
openaire   +5 more sources

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, Volume 117, Issue 1, Page 156-168, January 2026.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

Nerve growth factor nonresponsive pheochromocytoma cells: altered internalization results in signaling dysfunction. [PDF]

, 1992
Variant rat pheochromocytoma (PC12) cells which fail to respond to nerve growth factor (NGF) (PC12nnr5) (Green, S. H., R. E. Rydel, J. L. Connoly, and L. A. Greene. 1986. J. Cell Biol. 102:830-843) bind NGF at both high and low affinity sites.
Bradshaw, RA, Eveleth, DD
core  

Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus [PDF]

, 2006
Light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal ganglion cells. Previous work raised the possibility that brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related receptor kinase ...
Allen, Allen, Antle, Blum, Chao, Colwell, Ding, Gottesman, Hannibal, Hannibal, Hayashi, Herzog, Jelsma, Jobst, Lavezzari, Lee, Lessmann, Levine, Liang, Liang, Lin, Lundkvist, Michel, Michel, Moore, Morin, Nagappan, Nong, Obrietan, Rajagopal, Roenneberg, Schinder, Suzuki, Tischkau, Van Gelder, Vecino, Wu, Xu   +37 more
core   +1 more source

Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial–Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin‐Induced Pulmonary Fibrogenesis

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Background It was important to find better therapeutic drugs for idiopathic pulmonary fibrosis (IPF), and in our previous study, Yifei decoction (YFT) alleviated IPF. A deeper understanding of its mechanisms of action could aid in the development of novel treatment strategies.
Lijuan Chen, Chengzhong Lan, Xiangli Deng, Mei Wu, Mei Shao, Mei Yang, Xinwen Ma, Fen Huang, Haiyin Wu, Lipi Buch   +9 more
wiley   +1 more source

Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter [PDF]

, 1967
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Brunak, Søren, Halasz, Melinda, Huber, Kilian V.M., Kolch, Walter, Papamarkou, Theodore, Radic-Sarikas, Branka, Superti-Furga, Giulio, Tsafou, Kalliopi P., Winter, Georg E.   +8 more
core   +3 more sources