Results 101 to 110 of about 2,286,378 (300)
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, Volume 599, Issue 12, Page 1634-1648, June 2025.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Journal of Biological Chemistry, 2005 The human tumorous imaginal disc 1 (TID1) proteins including TID1L and TID1S, members of the DnaJ domain protein family, are involved in multiple intracellular signaling pathways such as apoptosis induction, cell proliferation, and survival.
Hui-yu Liu +4 more
semanticscholar +1 more source
Gangliosides Activate Trk Receptors by Inducing the Release of Neurotrophins [PDF]
Journal of Biological Chemistry, 2002 We used NIH‐3T3 fibroblasts expressing the different Trk receptors to examine whether GM1 ganglioside and its semisynthetic derivative LIGA20 activate various neurotrophin receptors. GM1 elicited a rapid activation of TrkC and TrkA, but not TrkB, tyrosine phosphorylation. In contrast, LIGA20 activated TrkB tyrosine phosphorylation only.
Alessia Bachis +2 more
openaire +4 more sources
Analytical Science Advances, Volume 6, Issue 1, June 2025.ABSTRACT Using LC–MS to screen and analyse the characteristics of components and biological systems is a new approach to study the pharmacological substance basis of traditional Chinese medicine, which has strong novelty in analytical science. This study analyses the antidepressant material basis of Zhizichi decoction through the integration strategy ...
Chuan Chai +7 more
wiley +1 more source
MoleculesTropomyosin receptor kinases (Trks) are transmembrane receptor tyrosine kinases named TrkA, TrkB, and TrkC and encoded by the NTRK1, NTRK2, and NTRK3 genes, respectively.
Amol T. Mahajan +5 more
doaj +1 more source
p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. [PDF]
, 2011 p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA) sub-population of basal keratinocytes.
DALLAGLIO, Katiuscia +9 more
core +1 more source
Elp1 function in placode‐derived neurons is critical for proper trigeminal ganglion development
Developmental Dynamics, Volume 254, Issue 6, Page 494-512, June 2025.Abstract Background The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned in the trigeminal ganglion, which arises from the coalescence of neural crest and placode cells. While this dual cellular origin has been known for decades, the molecular mechanisms controlling trigeminal ...
Margaret A. Hines, Lisa A. Taneyhill
wiley +1 more source
Frontiers in Molecular Neuroscience, 2017 Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling.
Yazan Haddad +5 more
doaj +1 more source
Role of neurotrophins on dermal fibroblast survival and differentiation [PDF]
, 2011 Neurotrophins (NTs) belong to a family of growth factors that play a critical role in the control of skin homeostasis. NTs act through the low-affinity receptor p75NTR and the high-affinity receptors TrkA, TrkB and TrkC.
Dallaglio, Katiuscia +9 more
core +3 more sources