Results 111 to 120 of about 2,385,649 (308)

Transactivation of Trk receptors in spinal motor neurons.

open access: yesHistology and histopathology, 2010
The neurotrophins are a family of trophic factors that have been shown to have neuroprotective effects after traumatic lesions of the nervous system and in animal models of neurodegenerative diseases. They mediate a broad spectrum of biological actions by interacting with tyrosine kinase receptors (Trk).
Domeniconi, Marco, Chao, Moses, V.
openaire   +3 more sources

ALK Expression in Nerve Sheath Myxoma: A Potential Diagnostic Pitfall

open access: yes
Journal of Cutaneous Pathology, EarlyView.
Daniel Cole   +6 more
wiley   +1 more source

Lifelong Impact of Prenatal Stress: Exacerbated Memory Impairments and Gene Expression Changes Under Adult Chronic Stress

open access: yesBrain and Behavior, Volume 15, Issue 12, December 2025.
ABSTRACT Introduction Chronic stress can have significant impacts on both physical and mental health, including affecting learning and memory processes. Research has shown that exposure to stress during prenatal and neonatal stages can have long‐lasting effects on individuals. The objective of this study is to investigate how prenatal stress influences
Manijeh Dogani   +2 more
wiley   +1 more source

Growth/Differentiation Factor 15 Promotes a Pro‐Regenerative Response in Chondrocytes Upon Cartilage Injury

open access: yesMedComm, Volume 6, Issue 12, December 2025.
After cartilage injury, oxidative stress results in a posttraumatic cell fate decision: Intracellular ROS accumulation initiates a p53‐dependent stress response in chondrocytes, including the transcription of signature genes, such as CDKN1A and GDF15.
Sara Sofi Marques   +5 more
wiley   +1 more source

NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts

open access: yesScientific Reports
Gastrointestinal stromal tumors (GISTs) are typically characterized by activating mutations of the KIT proto-oncogene receptor tyrosine kinase (KIT) or platelet-derived growth factor receptor alpha (PDGFRA).
Keita Sasa   +20 more
doaj   +1 more source

Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain [PDF]

open access: yes, 2006
The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation.
Kuraishi Yasushi   +3 more
core   +2 more sources

Subcellular Localization of Full-Length and Truncated Trk Receptor Isoforms in Polarized Neurons and Epithelial Cells

open access: yesJournal of Neuroscience, 1999
Neurotrophins affect neuronal development and plasticity via spatially localized effects, yet little is known about the subcellular distribution of the Trk neurotrophin receptors and the impact of this distribution on neurotrophin action. To address this,
D. Kryl   +5 more
semanticscholar   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li   +13 more
wiley   +1 more source

Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia

open access: yesNeurobiology of Disease, 2009
Administration of epidermal growth factor receptor (EGFR) inhibitors (e.g. AG1478/PD168393) promotes central nervous system (CNS) axon regeneration in vivo by an unknown mechanism.
Zubair Ahmed   +3 more
doaj   +1 more source

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