Results 121 to 130 of about 2,286,378 (300)

The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

BMC Evolutionary Biology, 2009
Background Neurotrophins and their Trk and p75NTR receptors play an important role in the nervous system. To date, neurotrophins, Trk and p75NTR have only been found concomitantly in deuterostomes.
Wilson Karen HS
doaj   +1 more source

Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults. [PDF]

, 2015
A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults.
Kollmann, Tobias R, Lissner, Michelle M, Smale, Stephen T, Thomas, Brandon J, Tong, Ann-Jay, Wee, Kathleen   +5 more
core   +3 more sources

On TRacK With Larotrectinib in a Neonate With a Giant Congenital ETV6::NTRK3 Fusion‐Positive Infantile Fibrosarcoma of the Head and Neck

Head &Neck, Volume 47, Issue 5, Page E50-E57, May 2025.
ABSTRACT Background Infantile fibrosarcoma (IFS) is a rare pediatric tumor of intermediate malignancy with high local aggressiveness that typically presents in young infants. Its occurrence in the head and neck region is rare. Complete non‐mutilating surgical resection is often not possible, requiring multimodal treatment.
Teresa M. Cardesa‐Salzmann, Monika Sparber‐Sauer, Peter Hingst, Andreas Erbersdobler, Bjoern Schneider, Maja Hühns, Andre Jakob, Friederike Terpe, Christian Spang, Dorothea Stalmann, Claudia Bierwirth, Christina Hauenstein, Stefanie Märzheuser, Manfred Ballmann, Carl Friedrich Classen   +14 more
wiley   +1 more source

Structural basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB

Nature Communications
Neurotrophin receptors of the Trk family are involved in the regulation of brain development and neuroplasticity, and therefore can serve as targets for anti-cancer and stroke-recovery drugs, antidepressants, and many others.
Erik F. Kot, Sergey A. Goncharuk, María Luisa Franco, Daniel M. McKenzie, Alexander S. Arseniev, Andrea Benito-Martínez, Mario Costa, Antonino Cattaneo, Kalina Hristova, Marçal Vilar, Konstantin S. Mineev   +10 more
doaj   +1 more source

The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2019
Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin, Laura E. Montroull, Marta Volosin, Wilma J. Friedman   +3 more
doaj   +1 more source

Trk: a neuromodulator of age-specific behavioral and neurochemical responses to cocaine in mice. [PDF]

, 2008
Responses to psychostimulants vary with age, but the molecular etiologies of these differences are largely unknown. The goal of the present research was to identify age-specific behavioral and molecular adaptations to cocaine and to elucidate the ...
Ehrlich, Michelle E, Miller, Jonathan S, Niculescu, Michelle, Perrine, Shane A, Unterwald, Ellen M   +4 more
core   +2 more sources

Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation.

PLoS ONE, 2013
Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation.
Ramesh Narayanan, Muralimohan Yepuru, Christopher C Coss, Zhongzhi Wu, Matthew N Bauler, Christina M Barrett, Michael L Mohler, Yun Wang, Juhyun Kim, Linda M Snyder, Yali He, Nelson Levy, Duane D Miller, James T Dalton   +13 more
doaj   +1 more source

High Affinity Not in the Vicinity? [PDF]

, 2007
Functional interactions between the p75 neurotrophin receptor (p75NTR) and the Trk receptors were demonstrated several years ago, but their mechanistic basis remains uncertain. In this issue of Neuron, Wehrman et al. provide a three-dimensional structure
Barker, Philip A.
core   +1 more source

Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]

, 1999
Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core  

Accumulation of the Drosophila Torso-like protein at the blastoderm plasma membrane suggests that it translocates from the eggshell [PDF]

, 2015
© 2015. Published by The Company of Biologists Ltd. The eggshell serves as a depository for proteins that play an important role in early embryonic development.
Casanova, Jordi, Furriols, Marc, Mineo, Alessandro   +2 more
core   +3 more sources