Results 121 to 130 of about 2,385,649 (308)

Neurotrophin/Trk receptor signaling mediates C/EBPα, -β and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription

Neural Development, 2007
BackgroundExtracellular signaling through receptors for neurotrophins mediates diverse neuronal functions, including survival, migration and differentiation in the central nervous system, but the transcriptional targets and regulators that mediate these ...
A. Calella, C. Nerlov, R. G. Lopez, C. Sciarretta, O. von Bohlen und Halbach, O. Bereshchenko, L. Minichiello   +6 more
semanticscholar   +1 more source

The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

BMC Evolutionary Biology, 2009
Background Neurotrophins and their Trk and p75NTR receptors play an important role in the nervous system. To date, neurotrophins, Trk and p75NTR have only been found concomitantly in deuterostomes.
Wilson Karen HS
doaj   +1 more source

Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels [PDF]

, 1998
Heteromultimeric G protein-activated inward rectifier K+ (GIRK) channels, abundant in heart and brain, help to determine the cellular membrane potential as well as the frequency and duration of electrical impulses. The sequence arginine-glycine-aspartate
Dang, Yan L., Davidson, Norman, Lester, Henry A., McPhee, Jancy C.   +3 more
core   +1 more source

Structural basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB

Nature Communications
Neurotrophin receptors of the Trk family are involved in the regulation of brain development and neuroplasticity, and therefore can serve as targets for anti-cancer and stroke-recovery drugs, antidepressants, and many others.
Erik F. Kot, Sergey A. Goncharuk, María Luisa Franco, Daniel M. McKenzie, Alexander S. Arseniev, Andrea Benito-Martínez, Mario Costa, Antonino Cattaneo, Kalina Hristova, Marçal Vilar, Konstantin S. Mineev   +10 more
doaj   +1 more source

The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2019
Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin, Laura E. Montroull, Marta Volosin, Wilma J. Friedman   +3 more
doaj   +1 more source

PD-28 Long-term efficacy and safety of larotrectinib in patients with tropomyosin receptor kinase (TRK) fusion gastrointestinal (GI) cancer: An updated analysis [PDF]

, 2023
Thierry André, David S. Hong, John F. Deeken, Antoîne Italiano, Tianshu Liu, Domnita-Ileana Burcoveanu, Ricarda Norenberg, Chiara Mussi, Rui‐Hua Xu, Alexander Drilon, Lin Shen   +10 more
openalex   +1 more source

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Boer, Sietse F. de,, Buwalda, Bauke,, Jong, Jelly G. de,, Koolhaas, Jaap M.,, Ruiter, Anne J.H. de,, Vegt, Bea J. van der,   +5 more
core   +1 more source

Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation.

PLoS ONE, 2013
Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation.
Ramesh Narayanan, Muralimohan Yepuru, Christopher C Coss, Zhongzhi Wu, Matthew N Bauler, Christina M Barrett, Michael L Mohler, Yun Wang, Juhyun Kim, Linda M Snyder, Yali He, Nelson Levy, Duane D Miller, James T Dalton   +13 more
doaj   +1 more source

CTNI-75. EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS [PDF]

, 2023
Sébastien Perreault, François Doz, Birgit Geoerger, Antoîne Italiano, Ulrik Lassen, Anna Nilsson, Karsten Nysom, Jean-Philippine Spano, Ricarda Norenberg, Vadim Bernard-Gauthier, Esther De La Cuesta, Alexander Drilon, Theodore W. Laetsch, Cornelis van Tilburg   +13 more
openalex   +1 more source

The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]

, 2018
AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G., Coskun, E., Erdoğan, Çağdaş, Ozkul, A., Sahin, B., Topcu, A., Yilmaz, A.   +6 more
core   +1 more source