Results 131 to 140 of about 2,286,378 (300)
Kidins220/ARMS as a functional mediator of multiple receptor signalling pathways [PDF]
, 2012 An increasing body of evidence suggests that several membrane receptors – in addition to activating distinct signalling cascades – also engage in substantial crosstalk with each other, thereby adjusting their signalling outcome as a function of specific ...
Benfenati, Fabio +3 more
core +1 more source
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]
, 2011 Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María +4 more
core +4 more sources
F1000ResearchBackground: NTRK1, NTRK2, and NTRK3 are members of the neurotrophic receptor tyrosine kinases (NTRK) family, which encode TrkA, TrkB, and TrkC receptors, respectively.
Fazil Ahmad +3 more
doaj
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain [PDF]
, 2016 The neurotrophin family of growth factors, comprised of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is implicated in the physiology of chronic pain.
Angus Nedderman +17 more
core +3 more sources
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas
Pathology and Oncology ResearchThe neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins.
Zoltán Lippai +5 more
doaj +1 more source
Selective coexpression of insulin receptor-related receptor (IRR) and TRK in NGF-sensitive neurons [PDF]
, 1994 RR Reinhardt +4 more
openalex +1 more source
Boosting pancreatic cancer chemotherapy by disrupting nerve–cancer crosstalk
Acta Materia MedicaA preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer.
Yutian Xia, Jianzhong Zhang
doaj +1 more source
Human Pathology Reports, 2022 Neurotrophic receptor tyrosine kinase (NTRK) gene fusions are oncogenic drivers found in a few rare tumours. However, NTRK rearrangements are being increasingly identified in a range of soft tissue neoplasms. Recognition of NTRK fusion-driven sarcomas is
Vanessa Young +3 more
doaj
Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. [PDF]
, 1992 Diego Pulido +4 more
openalex +1 more source