Results 141 to 150 of about 2,286,378 (300)

Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib

Acta Pharmaceutica Sinica B
Neurotrophic receptor kinase (NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors, and tropomyosin receptor kinase (TRK) has been considered as an attractive therapeutic target for “pan-cancer” harboring these ...
Shuang Xiang, Xiaoyun Lu
doaj  

Validation and interpretation of Pan-TRK immunohistochemistry: a practical approach and challenges with interpretation

Diagnostic Pathology
Objectives Actionable, solid tumor activating neurotrophic receptor tyrosine kinase (NTRK) fusions are best detected via nucleic acid-based assays, while Pan-TRK immunohistochemistry (IHC) serves as a reasonable screening modality.
Cansu Karakas, Ellen J. Giampoli, Tanzy Love, David G. Hicks, Moises J. Velez   +4 more
doaj   +1 more source

Вплив онкогенів на експресію рецепторних тирозинкіназ у пухлинах щитоподібної залози [PDF]

, 2009
Проведено порiвняльний аналiз злоякiсних та доброякiсних пухлин щитоподiбної залози вiдносно експресiї трансформованих та незмiнених рецепторних тирозинкiназ (TRK, RET/PTC, RET, MET, EGFR).
Богданова, Т.І., Воскобойник, Л.Г., Тронько, М.Д.   +2 more
core  

Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord

Journal of Pharmacological Sciences, 2005
The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj  

Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer’s Disease

Pharmaceuticals
Neurotrophins are important regulators of neuronal and non-neuronal functions. As such, the neurotrophins and their receptors, the tropomyosin receptor kinase (Trk) family of receptor tyrosine kinases, has attracted intense research interest and their ...
Pontus Forsell, Cristina Parrado Fernández, Boel Nilsson, Johan Sandin, Gunnar Nordvall, Märta Segerdahl   +5 more
doaj   +1 more source

BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia

Translational Neuroscience, 2015
Purpose: To investigate the effect of brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase (Trk) on potassium chloride cotransporter 2 (KCC2) in rats following nicotine withdrawal and the roles played by BDNF/Trk/KCC2 pathway in nicotine ...
Shi Wenhui, Ding Yonghong, Yu Ailan, Wang Qinghe, Zhang Zongwang, Zhang Li-Cai   +5 more
doaj   +1 more source

Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application [PDF]

, 2019
The use of kinase-directed precision medicine has been heavily pursued since the discovery and development of imatinib. Annually, it is estimated that around ∼20 000 new cases of tropomyosin receptor kinase (TRK) cancers are diagnosed, with the majority ...
Carlomagno, F, Frett, B, Gunaganti, N, Lakkaniga, NR, Li, H-Y, Lv, F, McDonald, NQ, Santoro, M, Yan, W   +8 more
core  

Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease [PDF]

, 2000
Fabio F. di Mola
openalex   +1 more source

Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

Acta Pharmaceutica Sinica B, 2020
Tingting Jiang, Guan Wang, Yao Liu, Lu Feng, Meng Wang, Jie Liu, Yi Chen, Ouyang Liang   +7 more
semanticscholar   +1 more source

Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1 [PDF]

, 2000
Dominique Melck, Luciano De Petrocellis, Pierangelo Orlando, Tiziana Bisogno, Chiara Laezza, Maurizio Bifulco, Vincenzo Di Marzo   +6 more
openalex   +1 more source