Results 141 to 150 of about 2,385,649 (308)

Validation and interpretation of Pan-TRK immunohistochemistry: a practical approach and challenges with interpretation

Diagnostic Pathology
Objectives Actionable, solid tumor activating neurotrophic receptor tyrosine kinase (NTRK) fusions are best detected via nucleic acid-based assays, while Pan-TRK immunohistochemistry (IHC) serves as a reasonable screening modality.
Cansu Karakas, Ellen J. Giampoli, Tanzy Love, David G. Hicks, Moises J. Velez   +4 more
doaj   +1 more source

Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer’s Disease

Pharmaceuticals
Neurotrophins are important regulators of neuronal and non-neuronal functions. As such, the neurotrophins and their receptors, the tropomyosin receptor kinase (Trk) family of receptor tyrosine kinases, has attracted intense research interest and their ...
Pontus Forsell, Cristina Parrado Fernández, Boel Nilsson, Johan Sandin, Gunnar Nordvall, Märta Segerdahl   +5 more
doaj   +1 more source

Neurotrophins and neuronal plasticity in the action of antidepressants and morphine [PDF]

, 2007
Neuronal plasticity is a well characterized phenomenon in the developing and adult brain. It refers to capasity of a single neuron to modify morphology, synaptic connections and activity.
Sairanen, Mikko
core  

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network

Annals of Oncology, 2020
G. Demetri, C. Antonescu, B. Bjerkehagen, J. Bovée, K. Boye, M. Chacon, A. Tos, Jayesh Desai, J. Fletcher, H. Gelderblom, S. George, A. Gronchi, R. Haas, N. Hindi, P. Hohenberger, H. Joensuu, R. Jones, I. Judson, Yoon-Koo Kang, A. Kawai, A. Lazar, A. Cesne, R. Maestro, R. Maki, J. Martín, Shreyaskumar R Patel, F. Penault-Llorca, C. Raut, P. Rutkowski, A. Safwat, M. Sbaraglia, I. Schaefer, Lin Shen, C. Serrano, P. Schöffski, S. Stacchiotti, K. Hall, W. Tap, David M. Thomas, J. Trent, C. Valverde, W.T.A. van der Graaf, W.T.A. van der Graaf, M. Mehren, A. Wagner, E. Wardelmann, Y. Naito, John R. Zalcberg, Jean-Yves Blay   +48 more
semanticscholar   +1 more source

44P A first-in-human, open-label, dose-escalation study to investigate the safety and tolerability of CHC2014, a tropomyosin receptor kinase (TRK) inhibitor, in adult patients with advanced solid tumors

, 2022
Tak Yun, Su‐Jin Shin, Dae‐Wi Kim, Chul‐Ho Yun, SuJin Heo, BokJin Hyun, Y.S. Kim, J.S. Kim, Yong Wha Moon   +8 more
openalex   +2 more sources

Astrocytes Regulate Inhibitory Synapse Formation via Trk-Mediated Modulation of Postsynaptic GABA_AReceptors [PDF]

, 2005
Sarina B. Elmariah, Eun Joo Oh, Ethan G. Hughes, Rita J. Balice‐Gordon   +3 more
openalex   +1 more source

Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]

, 1999
Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core  

Detection of new anti‐neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors [PDF]

, 2006
Takateru Mihara, Akihiro Ueda, Masaaki Hirayama, T Takeuchi, Satoshi Yoshida, Kensei Naito, Hiroko Yamamoto, Tatsuro Mutoh   +7 more
openalex   +1 more source

Oncogenic influences of neurotrophin receptors: Shedding light on Trk biology

Cell Reports
Summary: During critical stages of neurodevelopment, tropomyosin receptor kinase receptors, encoded by NTRK genes, exhibit temporally driven differential peaks of expression to properly guide the establishment of the peripheral and central nervous ...
Hawa L. Jagana, Maryam M. Shabar, Taylor S. Jackson, David E. Johnson, John M. Hemenway, Visakha Mukkamala, Aleksandra Lukasik, Matthew R. Hathaway, Siobhan S. Pattwell   +8 more
doaj   +1 more source

Muscle-specific trk-related receptor with a kringle domain defines a distinct class of receptor tyrosine kinases. [PDF]

, 1993
Charles Jennings, S M Dyer, Steven J. Burden   +2 more
openalex   +1 more source