Results 11 to 20 of about 2,286,378 (300)
Involvement of TRK receptors in the nootropic effect of cycloprolylglycine
Фармакокинетика и ФармакодинамикаBackground. The neuropeptide cycloprolylglycine (CPG) is an endogenous dipeptide analogue of the nootropic piracetam. It has been experimentally shown that CPG (designed and synthesized at the Federal State Budgetary Scientific Institution «Federal ...
O. N. Vorontsova +5 more
doaj +3 more sources
p75 neurotrophin receptor reduces ligand‐induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation [PDF]
EMBO reports, 2005 Target‐derived neurotrophins regulate neuronal survival and growth by interacting with cell‐surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75NTR) is coexpressed with Trk receptors in long‐range projection neurons, in which it facilitates neurotrophin binding to Trk and enhances Trk activity.
Joe Makkerh +5 more
semanticscholar +6 more sources
The significance of Trk receptors in pancreatic cancer [PDF]
Tumor Biology, 2017 This study investigated the Trk receptor family as a therapeutic target in pancreatic ductal adenocarcinoma and assessed their prognostic significance.
Matthew D Johnson +13 more
doaj +3 more sources
RET receptor expression and interaction with TRK receptors in neuroblastomas.
Oncology Reports, 2020 Neuroblastomas (NBs) have heterogeneous clinical behavior, from spontaneous regression or differentiation to relentless progression. Evidence from our laboratory and others suggests that neurotrophin receptors contribute to these disparate behaviors ...
L. Tetri +12 more
semanticscholar +4 more sources
Transphosphorylation of the Neurotrophin Trk Receptors [PDF]
Journal of Biological Chemistry, 1996 The potential for the activation of one Trk receptor by ligand binding to another Trk receptor was explored by determining if transphosphorylation on tyrosine residues can occur between receptors. For most of these experiments, functional chimeric receptors were used that contained the extracellular domain of the human type 2 tumor necrosis factor ...
Marco Canossa +2 more
openalex +5 more sources
Fish neurotrophins and Trk receptors [PDF]
International Journal of Developmental Neuroscience, 2000 Gerhard Heinrich, Tom Lum
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Five Trk Receptors in the Zebrafish
Developmental Biology, 1995 Using a homology-based cloning strategy we have identified five members of the Trk family in the zebrafish Danio rerio. They are homologous to the three mammalian Trk receptors in their conserved intracellular kinase regions and the organization of their extracellular regions.
Stella C. Martin +3 more
openalex +4 more sources
A temporal (phospho-)proteomic dataset of neurotrophic receptor tyrosine kinase signalling in neuroblastoma [PDF]
Scientific DataNeurotrophic receptor tyrosine kinases (TrkA, TrkB, TrkC), despite their homology, contribute to the clinical heterogeneity of the childhood cancer neuroblastoma.
Stephanie Maher +3 more
doaj +2 more sources
The effect of P75 on Trk receptors in neuroblastomas [PDF]
Cancer Letters, 2011 Neuroblastomas (NBs) with favorable outcome usually express TrkA, whereas unfavorable NBs frequently express TrkB and its cognate ligand BDNF. P75 (p75(LNTR), NGFR, TNFRSF16) binds NGF-related neurotrophins with low affinity and usually is coexpressed with Trk receptors in NBs. Here, we investigated the importance of p75 coexpression with Trk receptors
Ruth Ho +6 more
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Signal Transduction Pathways through TRK‐A and TRK‐B Receptors in Human Neuroblastoma Cells [PDF]
Japanese Journal of Cancer Research, 2001 Little is known about the signal transduction pathways of TRK family receptors in neuroblastoma (NB) cells. In this study, an NB cell line, designated MP‐N‐TS, was established from an adrenal tumor taken from a 2‐year‐old boy. This cell line expressed both TRK‐A and TRK‐B receptors, which is rare in a single NB cell line.
Tohru Sugimoto +5 more
openalex +5 more sources