Results 251 to 260 of about 2,286,378 (300)

Trk receptors: mediators of neurotrophin action

Current Opinion in Neurobiology, 2001
The four mammalian neurotrophins - NGF, BDNF, NT-3 and NT-4 - each bind and activate one or more of the Trk family of receptor tyrosine kinases. Through these receptors, neurotrophins activate many intracellular signaling pathways, including those controlled by Ras, the Cdc42/Rac/RhoG protein family, MAPK, PI3K and PLC-gamma, thereby affecting both ...
Ardem Patapoutian, Louis F. Reichardt
openaire   +3 more sources

Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging.

Journal of Medicinal Chemistry, 2018
Changes in expression and dysfunctional signaling of TrkA/B/C receptors and oncogenic Trk fusion proteins are found in neurological diseases and cancers. Here, we describe the development of a first 18F-labeled optimized lead suitable for in vivo imaging
V. Bernard-Gauthier, Andrew V. Mossine, Anne Mahringer, Arturo Aliaga, Justin J Bailey, X. Shao, J. Stauff, Janna Arteaga, P. Sherman, Marilyn Grand'maison, Pierre-Luc Rochon, B. Wängler, C. Wängler, P. Bartenstein, A. Kostikov, D. Kaplan, G. Fricker, P. Rosa-Neto, P. Scott, R. Schirrmacher   +19 more
semanticscholar   +1 more source

p75 and Trk: A two-receptor system

Trends in Neurosciences, 1995
The neurotrophin family of survival factors is distinguished by a unique receptor-signaling system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4/5 share similar protein structures and biological functions and interact with two different types of cell-
Barbara L. Hempstead, Moses V. Chao
openaire   +3 more sources

Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina

Developmental Brain Research, 1999
In this study, the ontogeny and distribution patterns of three neurotrophin receptors (Trk A, Trk B, and Trk C) were examined in the human retinas. Immunohistochemistry was performed on sections of retina and optic nerve from fetuses (11-24 weeks of gestation, wg), one infant (4-month-old) and two adult (35- and 65-years-old) subjects.
Tapas Chandra Nag, Shashi Wadhwa
openaire   +3 more sources

The Trk family of neurotrophin receptors

Journal of Neurobiology, 1994
AbstractAccumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk (also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the NGF family of neurotrophins. Nerve growth factor (NGF) specifically recognizes Trk, a receptor indentified in all major NGF targets, including sympathetic ...
openaire   +3 more sources

Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents.

ACS Chemical Neuroscience, 2015
Tropomyosin receptor kinases (TrkA/B/C) are critically involved in the development of the nervous system, in neurological disorders as well as in multiple neoplasms of both neural and non-neural origins.
V. Bernard-Gauthier, Arturo Aliaga, A. Aliaga, M. Boudjemeline, R. Hopewell, A. Kostikov, P. Rosa-Neto, A. Thiel, R. Schirrmacher   +8 more
semanticscholar   +1 more source

The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers.

, 2017
LBA2501Background: Larotrectinib is the first selective small-molecule pan-TRK inhibitor. TRK fusions appear oncogenic independent of tumor lineage, are widely distributed across cancers, and affect all ages.
D. Hyman, T. Laetsch, S. Kummar, S. DuBois, A. Farago, A. Pappo, G. Demetri, W. El-Deiry, U. Lassen, A. Dowlati, M. Brose, V. Boni, B. Turpin, R. Nagasubramanian, S. Cruickshank, M. Cox, N. Ku, D. Hawkins, D. Hong, A. Drilon   +19 more
semanticscholar   +1 more source

Expression of neurotrophins and Trk receptors in the avian retina

The Journal of Comparative Neurology, 1996
Using the RNase protection assay, we have found that nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are expressed in the avian retina during development. The expression peaks around embryonic days 12-15, with decreasing levels at later stages of development.
Anders Bäckström, Klas Kullander, Néstor G. Carri, Ted Ebendal, Finn Hallböök   +4 more
openaire   +3 more sources

Origin and evolution of the Trk family of neurotrophic receptors

Molecular and Cellular Neuroscience, 2006
Among the numerous tyrosine kinase receptors, those belonging to the Trk family are distinctively involved in the development of complex traits within the vertebrate nervous system. Until recently, the lack of a proper Nt/Trk system in invertebrates has lead to the belief that they were a vertebrate innovation. Recent data, however, have challenged the
Jordi Garcia-Fernàndez, Èlia Benito-Gutiérrez, Joan X. Comella   +2 more
openaire   +3 more sources

Expression of Trk Receptors during Cartilage Differentiation

Annals of the New York Academy of Sciences, 1996
The products of the tyrosine kinase trk family of proto-oncogenes bind neurotrophins (NTFs) and are components of their high-affinity receptors. The trk gene encodes for the TrkA transmembrane glycoprotein, which functions as a receptor for nerve growth factor (NGF).
JosÉ-Luis Urdiales, Elena Becker, Thimios A. Mitsiadis, Urban Lendahl, Brian B. Rudkin, J. Wroblewski, Dionisio Martin-Zanca   +6 more
openaire   +3 more sources