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Trk neurotrophin receptor activators
Drug News & Perspectives, 2002The neurotrophins are a small group of proteins whose binding at the tropomyosin related kinase (Trk) and p75 neurotrophin receptor transmembrane receptors triggers a cascade of signaling events that give rise to neurotrophic responses in neuronal cells and in vivo.
Scott J., Pollack, Sarah J., Harper
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Trk receptor alterations in Alzheimer's disease
Molecular Brain Research, 1996The expression of trk receptors in postmortem normal, Huntington's disease and Alzheimer's disease human brains was investigated using immunohistochemistry, in-situ hybridisation and Western blotting. Alzheimer's disease hippocampi displayed an increase in trkA receptor levels in astrocytes in the CA1 region, some of which were associated with beta ...
B, Connor +6 more
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2014
The tropomyosin-related tyrosine kinase (Trk) receptors were initially described as a family of growth factor receptors required for neuronal survival. They have since been shown to influence many aspects of neuronal development and function, including differentiation, outgrowth, and synaptic plasticity.
Katrin, Deinhardt, Moses V, Chao
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The tropomyosin-related tyrosine kinase (Trk) receptors were initially described as a family of growth factor receptors required for neuronal survival. They have since been shown to influence many aspects of neuronal development and function, including differentiation, outgrowth, and synaptic plasticity.
Katrin, Deinhardt, Moses V, Chao
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Trk receptors: mediators of neurotrophin action
Current Opinion in Neurobiology, 2001The four mammalian neurotrophins - NGF, BDNF, NT-3 and NT-4 - each bind and activate one or more of the Trk family of receptor tyrosine kinases. Through these receptors, neurotrophins activate many intracellular signaling pathways, including those controlled by Ras, the Cdc42/Rac/RhoG protein family, MAPK, PI3K and PLC-gamma, thereby affecting both ...
A, Patapoutian, L F, Reichardt
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Lipopolysaccharide differentially regulates microglial trk receptor and neurotrophin expression
Journal of Neuroscience Research, 1998Activated brain microglia play a pivotal role in inflammatory and degenerative disorders, mediating immune function and producing toxic and trophic agents. We previously reported that microglia express neurotrophins and that neurotrophin-3 (NT-3) increases microglial proliferation and phagocytosis, processes associated with cellular activation. However,
S. Elkabes, Lang Peng, I. Black
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Expression of Trk Receptors during Cartilage Differentiation
Annals of the New York Academy of Sciences, 1996The products of the tyrosine kinase trk family of proto-oncogenes bind neurotrophins (NTFs) and are components of their high-affinity receptors. The trk gene encodes for the TrkA transmembrane glycoprotein, which functions as a receptor for nerve growth factor (NGF).
T A, Mitsiadis +6 more
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Transcriptional regulation of Trk family neurotrophin receptors
Cellular and Molecular Life Sciences, 2006The Trk family of neurotrophin receptors plays essential roles in cell fate specification, survival, growth, and differentiation. Their expression patterns are complex and dynamically regulated under many physiological and pathological conditions. However, the molecular mechanisms that control their tissue-specific expression are largely unknown.
L, Lei, L F, Parada
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Trk Receptors: Roles in Neuronal Signal Transduction
Annual Review of Biochemistry, 2003▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).
Eric J, Huang, Louis F, Reichardt
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Science's STKE, 2005
No true invertebrate homologs of the vertebrate neurotrophin Trk receptors have been identified in the genomes of the model organisms Drosophila melanogaster and Caenorhabditis elegans , which has led to the hypothesis that the Trk signaling arose in vertebrates. Benito-Gutiérrez
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No true invertebrate homologs of the vertebrate neurotrophin Trk receptors have been identified in the genomes of the model organisms Drosophila melanogaster and Caenorhabditis elegans , which has led to the hypothesis that the Trk signaling arose in vertebrates. Benito-Gutiérrez
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The Trk family of neurotrophin receptors
Journal of Neurobiology, 1994AbstractAccumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk (also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the NGF family of neurotrophins. Nerve growth factor (NGF) specifically recognizes Trk, a receptor indentified in all major NGF targets, including sympathetic ...
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