Results 261 to 270 of about 2,385,649 (308)

p75 and Trk: A two-receptor system

Trends in Neurosciences, 1995
The neurotrophin family of survival factors is distinguished by a unique receptor-signaling system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4/5 share similar protein structures and biological functions and interact with two different types of cell-
M V, Chao, B L, Hempstead
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Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina

Developmental Brain Research, 1999
In this study, the ontogeny and distribution patterns of three neurotrophin receptors (Trk A, Trk B, and Trk C) were examined in the human retinas. Immunohistochemistry was performed on sections of retina and optic nerve from fetuses (11-24 weeks of gestation, wg), one infant (4-month-old) and two adult (35- and 65-years-old) subjects.
T C, Nag, S, Wadhwa
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Alterations in Trk A, Trk B and Trk C Receptor Immunoreactivities in Parietal Cortex and Cerebellum in Alzheimer’s Disease

European Neurology, 2000
The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity. We investigated the expression of the trk receptors in the parietal cortex (PC) and cerebellum of patients with Alzheimer’s disease (AD) and age-matched ...
E, Savaskan, F, Müller-Spahn, G, Olivieri, S, Bruttel, U, Otten, C, Rosenberg, C, Hulette, C, Hock   +7 more
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The teleost kidney expresses Trk Neurotrophin Receptor-Like Proteins

Anatomy and Embryology, 2000
Neurotrophins are involved in the development and maintenance of some neuronal populations, acting through tyrosine protein kinase (Trk) receptors, TrkA, TrkB and TrkC. In addition, recent studies have demonstrated the occurrence of Trk receptors in a wide variety of adult and embryonic non-neuronal tissues in vertebrates, including kidney ...
DE GIROLAMO, PAOLO, ARCAMONE, NADIA, LUCINI, CARLA, CASTALDO, LUCIANA, VEGA J. A., GARGIULO G.   +5 more
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Activation of TRK Genes in Ewingʼs Sarcoma Trk A Receptor Expression Linked to Neural Differentiation

Diagnostic Molecular Pathology, 1997
Trk receptors have been identified by immunohistochemical methods in primitive neuroectodermal tumor (PNET)/Ewing's sarcoma (ES). However, the presence of different members of the Trk family of receptors in PNET/ES has not been specified. We have examined whether Trk A, B, and C receptors are specifically expressed in ES both with and without features ...
E, Nogueira, S, Navarro, A, Pellín, A, Llombart-Bosch   +3 more
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Biochemical Characterization of Intracellular Membranes Bearing Trk Neurotrophin Receptors

Neurochemical Research, 2005
Neurotrophin receptor trafficking plays an important role in directing cellular communication in developing as well as mature neurons. However, little is known about the requirements for intracellular localization of the neurotrophin receptors in neurons.
Hiroko, Yano, Moses V, Chao
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The trk family of oncogenes and neurotrophin receptors.

Princess Takamatsu symposia, 1992
To date more than twenty five different oncogenes have been identified in human neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a colon carcinoma biopsy by using gene transfer assays. This oncogene encodes a chimeric molecule that contains the 221 amino terminal residues of a non-muscle tropomyosin followed by ...
Lamballe, F., Klein, R., Barbacid, M.
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Fish neurotrophins and Trk receptors

International Journal of Developmental Neuroscience, 2000
G, Heinrich, T, Lum
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Neurotrophins and TRK Receptors in Hippocampal Development

1995
The mammalian nervous system is composed of a large number of differentiated neuronal and glial cell types, which develop from precursor cells during the early development of the brain. Many aspects of the transition of proliferating precursors into differentiated cell types remain elusive because of the complexity of the brain.
Diana Collazo, Ron McKay
openaire   +1 more source

Neurotrophin Trk Receptors: New Targets for Cancer Therapy

2017
In the last few years, exciting reports have emerged regarding the role of the two types of neurotrophin receptors, p75NTR and Trks, not only in neurons, where they were discovered, but also in non-neural cells and, especially, in numerous cancers, including breast, lung, colon-rectum, pancreas, prostate, glioblastoma, neuroblastoma, myeloma, and ...
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