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European Neurology, 2000
The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity. We investigated the expression of the trk receptors in the parietal cortex (PC) and cerebellum of patients with Alzheimer’s disease (AD) and age-matched ...
Uwe Otten +7 more
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The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity. We investigated the expression of the trk receptors in the parietal cortex (PC) and cerebellum of patients with Alzheimer’s disease (AD) and age-matched ...
Uwe Otten +7 more
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Trk Receptors: Roles in Neuronal Signal Transduction
Annual Review of Biochemistry, 2003▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).
Eric J. Huang, Louis F. Reichardt
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Transcriptional regulation of Trk family neurotrophin receptors
Cellular and Molecular Life Sciences, 2006The Trk family of neurotrophin receptors plays essential roles in cell fate specification, survival, growth, and differentiation. Their expression patterns are complex and dynamically regulated under many physiological and pathological conditions. However, the molecular mechanisms that control their tissue-specific expression are largely unknown.
Lei Lei, Luis F. Parada
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Effects of dark rearing on phosphorylation of neurotrophin Trk receptors
European Journal of Neuroscience, 2002AbstractTotal lack of visual experience (dark rearing, DR) is known to affect development of mammalian visual cortex (VC) and to prolong the critical period of visual cortical plasticity. Neurotrophins (NTs) have been proposed to play a relevant role in activity dependent processes important for the final shaping of cortical visual connections ...
VIEGI A +4 more
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European Journal of Cancer, 1997
Neuroblastoma, a childhood tumour of the sympathetic nervous system, may sometimes regress spontaneously in infants, or progress to a poor clinical outcome despite intensive therapy. Neuroblastomas express neurotrophin receptors and high levels of mRNA for trk-A correlates with favourable outcome, whereas trk-B mRNA is expressed by more unfavourable ...
T. Svensson +6 more
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Neuroblastoma, a childhood tumour of the sympathetic nervous system, may sometimes regress spontaneously in infants, or progress to a poor clinical outcome despite intensive therapy. Neuroblastomas express neurotrophin receptors and high levels of mRNA for trk-A correlates with favourable outcome, whereas trk-B mRNA is expressed by more unfavourable ...
T. Svensson +6 more
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Diagnostic Molecular Pathology, 1997
Trk receptors have been identified by immunohistochemical methods in primitive neuroectodermal tumor (PNET)/Ewing's sarcoma (ES). However, the presence of different members of the Trk family of receptors in PNET/ES has not been specified. We have examined whether Trk A, B, and C receptors are specifically expressed in ES both with and without features ...
Antonio Llombart-Bosch +3 more
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Trk receptors have been identified by immunohistochemical methods in primitive neuroectodermal tumor (PNET)/Ewing's sarcoma (ES). However, the presence of different members of the Trk family of receptors in PNET/ES has not been specified. We have examined whether Trk A, B, and C receptors are specifically expressed in ES both with and without features ...
Antonio Llombart-Bosch +3 more
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Neurotrophins and TRK Receptors in Hippocampal Development
1995The mammalian nervous system is composed of a large number of differentiated neuronal and glial cell types, which develop from precursor cells during the early development of the brain. Many aspects of the transition of proliferating precursors into differentiated cell types remain elusive because of the complexity of the brain.
Ronald D.G. McKay, Diana Collazo
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Molecular evolution of the neurotrophin family members and their Trk receptors
Gene, 2007Neurotrophins are structurally related proteins regulating brain development and function. Molecular evolution studies of neurotrophins and their receptors are essential for understanding the mechanisms underlying the coevolution processes of these gene families and how they correlate with the increased complexity of the vertebrate nervous system.
Lanave, C +3 more
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Structural and Functional Properties of the TRK Family of Neurotrophin Receptors
Annals of the New York Academy of Sciences, 1995The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors that mediate the biological properties of the NGF family of neurotrophins. This family of growth factors includes in addition to NGF, BDNF, NT-3, and NT-4. TrkA is the NGF receptor.
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