Results 31 to 40 of about 2,286,378 (300)

Role of STAT3 in in vitro transformation triggered by TRK oncogenes. [PDF]

PLoS ONE, 2010
TRK oncoproteins are chimeric versions of the NTRK1/NGF receptor and display constitutive tyrosine kinase activity leading to transformation of NIH3T3 cells and neuronal differentiation of PC12 cells.
Claudia Miranda, Tiziana Fumagalli, Maria Chiara Anania, Maria Grazia Vizioli, Sonia Pagliardini, Marco A Pierotti, Angela Greco   +6 more
doaj   +1 more source

Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [PDF]

, 2020
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative potential. Neurotrophins are
Benítez Temiño, Beatriz, Carrero Rojas, Génova, Davis López de Carrizosa, María América, Pastor Loro, Ángel Manuel   +3 more
core   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Thoracic Cancer, 2022
Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application.
Chunwei Xu, Lu Si, Wenxian Wang, Ziming Li, Zhengbo Song, Qian Wang, Aijun Liu, Jinpu Yu, Wenfeng Fang, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Lei Lei, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Xiao Hu, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Jiancheng Luo, Hongtao Jia, Xiaowei Dong, Fei Pang, Kai Wang, Liping Wang, Youcai Zhu, Yanru Xie, Xinqin Lin, Jing Cai, Jia Wei, Fen Lan, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Bing Wan, Donglai Lv, Qing Wei, Jin Kang, Jiatao Zhang, Chao Zhang, Genhua Yu, Juanjuan Ou, Lin Shi, Zhongwu Li, Zhefeng Liu, Jing Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Liu Yang, Guansong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Yiping Zhang, Shenglin Ma, Biyun Wang, Xiaotian Zhang, Yong Song, Yuanzhi Lu   +110 more
doaj   +1 more source

Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation [PDF]

, 2008
Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival ...
Aberle, Alcantara, Alicia Hidalgo, Altar, Arancio, Arenas, Arendt, Armstrong, Bangfu Zhu, Barde, Barres, Beck, Belluardo, Ben Sutcliffe, Benito-Gutierrez, Bergmann, Bergner, Blum, Booth, Bossing, Bothwell, Broihier, Buj-Bello, Burke, Campos, Cash, Chao, Chen, Chevrel, Chun-Jing Gu, Coen, Collette, Collins, Conover, Crowley, Davies, Dearborn, DeLotto, Denes, Dong, Enokido, Ernfors, Ernfors, Fischbach, Freudenthal, Gangloff, Geddes, Halfon, Halfon, Hallbö, Hashimoto, Hemmrich, Henderson, Hidalgo, Hofer, Hu, Huang, Hyman, Inamori, Jaaro, Jacob, Jacobs, Janine C Fenton, Jenny A Pennack, Keishishian, Keishishian, Kenji Mizuguchi, Kirstein, Klein, Landgraf, Landgraf, Landgraf, Landgraf, Landgraf, Learte, Lee, Levi-Montalcini, Ligoxigakis, Liu, Liu, Lu, Ma, Manjon, Manuel G Forero, Martinowich, Mattson, McCabe, Means, Memet, Michael Bate, Minichiello, Mizuguchi, Mizuguchi, Morisato, Moroz, Morris, Noordermeer, Odden, Oppenheim, Oppenheim, Ormond, Parker, Peter McQuilton, Pezet, Putnam, Rogulja-Ortmann, Rose, Roux, Rubin, Sali, Scarabelli, Schmidt, Schwartz, Schweigreiter, Sendtner, Shi, Silos-Santiago, Sink, Sink, Snider, Sofroniew, Sonnenfeld, Sossin, Stadelmann, Staniszewska, Stemerdink, Tauszig, van Kesteren, Venter, Wang, Weber, Weber, White, Wright, Xiong, Zhou, Zweifel   +136 more
core   +4 more sources

The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study.

Biochemical Journal, 2020
Tropomyosin receptor kinase B (Trk-B) belongs to the second largest family of membrane receptors, Receptor Tyrosine Kinases (RTKs). Trk-B is known to interact with three different neurotrophins: Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-4 ...
Fozia Ahmed, Michael D. Paul, K. Hristova   +2 more
semanticscholar   +1 more source

Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis [PDF]

, 2006
The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation.
Aiga, Ayako, Asaumi, Koji, Kadota, Hiroaki, Lee, You Jin, Mitani, Shigeru, Ozaki, Toshifumi, Takigawa, Masaharu   +6 more
core   +1 more source

Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma

European Journal of Endocrinology, 2022
Objective Larotrectinib is a highly selective tropomyosin receptor kinase (TRK) inhibitor with demonstrated efficacy across various TRK fusion-positive solid tumours.
S. Waguespack, A. Drilon, Jessica J. Lin, M. Brose, R. McDermott, M. Almubarak, J. Bauman, M. Casanova, A. Krishnamurthy, S. Kummar, S. Leyvraz, D. Oh, Keunchil Park, D. Sohal, E. Sherman, R. Norenberg, J. Silvertown, N. Brega, D. Hong, M. Cabanillas   +19 more
semanticscholar   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system [PDF]

, 2018
A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally.
Bogetti, María Eugenia, Fiszer de Plazas, Sara, Flores, Domingo Vladimir, Pozo Devoto, Victorio Martin, Rapacioli, Melina   +4 more
core   +1 more source