Results 71 to 80 of about 2,286,378 (300)

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

The Suppressive Effect of an Intra-Prefrontal Cortical Infusion of BDNF on Cocaine-Seeking Is Trk Receptor and Extracellular Signal-Regulated Protein Kinase Mitogen-Activated Protein Kinase Dependent

Journal of Neuroscience, 2011
Cocaine-mediated neuroadaptations in the prefrontal cortical-nucleus accumbens pathway underlie drug-seeking in animals with a cocaine self-administration (SA) history.
Timothy W. Whitfield, Xiangdang Shi, Wei-Lun Sun, J. McGinty   +3 more
semanticscholar   +1 more source

Delivered cost of switchgrass pellets transported from depots to a biorefinery in the Piedmont, USA

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The southeast region of the USA has the potential to be a significant producer of biobased products; however, research is needed to demonstrate the most cost‐effective feedstock delivery system. This study considers a distributed network of five pellet depots to supply feedstock (i.e., switchgrass pellets) for the operation of a hypothetical ...
Jonathan P. Resop, John S. Cundiff, Shahabaddine Sokhansanj   +2 more
wiley   +1 more source

BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors

npj Precision Oncology
Aberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng, Hong Chen, Bang Fu, Hongming Pan, Jiabing Wang, Weidong Han   +5 more
doaj   +1 more source

Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]

, 2016
The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela, Giarnieri, Enrico, Giovagnoli, Maria Rosaria, Mancini, Rita, Mariotta, Salvatore, Ricci, Alberto   +5 more
core   +1 more source

Conversion Surgery After Administration of a TRK Inhibitor for Unresectable Parotid Gland Secretory Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Arisa Nagano, Takuma Matoba, Daisuke Kawakita, Kiyoshi Minohara, Sho Iwaki, Hiroshi Tsuge, Koji Tsukamoto, Sekai Kikuchi, Satsuki Nakano, Takayuki Murase, Yuichiro Tada, Shinichi Iwasaki   +11 more
wiley   +1 more source

Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma [PDF]

Journal of Biosciences, 2003
Neurotrophins and their receptors of the Trk family play a critical role in proliferation, differentiation and survival of the developing neurons. There are reports on their expression in neoplasms too, namely, the primitive neuroectodermal tumours of childhood, and in adult astrocytic gliomas.
Rahul Kushwaha, Tapas Chandra Nag, Anupam Jindal, Chitra Sarkar, Ashok Kumar Mahapatra, Shashi Wadhwa   +5 more
openaire   +2 more sources

Heterogeneous intracellular trafficking dynamics of brain-derived neurotrophic factor complexes in the neuronal soma revealed by single quantum dot tracking. [PDF]

PLoS ONE, 2014
Accumulating evidence underscores the importance of ligand-receptor dynamics in shaping cellular signaling. In the nervous system, growth factor-activated Trk receptor trafficking serves to convey biochemical signaling that underlies fundamental neural ...
Anke Vermehren-Schmaedick, Wesley Krueger, Thomas Jacob, Damien Ramunno-Johnson, Agnieszka Balkowiec, Keith A Lidke, Tania Q Vu   +6 more
doaj   +1 more source

Statistical Complexity of Quantum Learning

Advanced Quantum Technologies, EarlyView.
The statistical performance of quantum learning is investigated as a function of the number of training data N$N$, and of the number of copies available for each quantum state in the training and testing data sets, respectively S$S$ and V$V$. Indeed, the biggest difference in quantum learning comes from the destructive nature of quantum measurements ...
Leonardo Banchi, Jason Luke Pereira, Sharu Theresa Jose, Osvaldo Simeone   +3 more
wiley   +1 more source

Expression of Trk A receptors in the mammalian inner ear [PDF]

Hearing Research, 2004
Tyrosine kinase receptors, including Trk A, Trk B and Trk C, participate in many different biological processes that are regulated by neurotrophic factors. Nerve growth factor (NGF)-triggered Trk A signaling is involved in growth, survival and differentiation of neurons in the central nervous system and in neural crest-derived cells.
Zhengmin Wang, Zoltan Vass, Peter S. Steyger, Chunfu Dai, Alfred L. Nuttall, Alfred L. Nuttall   +5 more
openaire   +3 more sources