Results 1 to 10 of about 258,223 (150)
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Nature Biotechnology, 2023 Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is lacking.
M. Lucas +8 more
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The tRNA identity landscape for aminoacylation and beyond
Nucleic Acids Research, 2023 tRNAs are key partners in ribosome-dependent protein synthesis. This process is highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases and relies primarily on sets of identities within tRNA molecules composed of ...
R. Giegé, G. Eriani
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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Molecules and Cells, 2021 The emerging "epitranscriptomics" field is providing insights into the biological and pathological roles of different RNA modifications. The RNA methyltransferase METTL1 catalyzes N7-methylguanosine (m7G) modification of tRNAs.
Esteban A. Orellana +20 more
semanticscholar +1 more source
Molecules and Cells, 2021 Summary Measurements of cellular tRNA abundance are hampered by pervasive blocks to cDNA synthesis at modified nucleosides and the extensive similarity among tRNA genes.
Andrew Behrens +2 more
semanticscholar +1 more source
Small regulatory RNAs: from bench to bedside – a keystone symposia meeting report
RNA Biology, 2023 The Keystone Symposium ‘Small Regulatory RNAs: From Bench to Bedside’ was held in Santa Fe, New Mexico from May 1–4, 2022. The symposium was organized by Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt, and brought together scientists working
Soo Mi Lee +3 more
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Molecular Therapy, 2021 Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The transfer RNAs (tRNAs) are the most heavily modified RNA species in cells, however, little is known about the functions of tRNA modifications in cancers.
Jieyi Ma +12 more
semanticscholar +1 more source
Molecules and Cells, 2021 Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate cancer survival and progression, but the underlying mechanisms are poorly understood.
Z. Dai +14 more
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Breaking the genetic code – a new revolutionary stage in the development of molecular biology: 1968 Nobel Prize laureates M. W. Nirenberg, H. G. Khorana, R. W. Holley [PDF]
The Ukrainian Biochemical Journal, 2021 This review presents the life stories of M. Nirenberg, H. Khorana, and R. Holley, winners of the 1968 Nobel Prize in Physiology or Medicine, the history of the discoveries made by these scientists, and the methodological approaches used in their works ...
O. P. Matyshevska +2 more
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Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes [PDF]
Open Biology, 2017 RNA polymerase III (Pol III) transcribes a limited set of short genes in eukaryotes producing abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome appears to be expanding owing to the application of new methods.
Ewa Leśniewska, Magdalena Boguta
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METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Clinical and Translational Medicine, 2021 Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood ...
Zhi-hang Chen +14 more
semanticscholar +1 more source