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Breaking the genetic code – a new revolutionary stage in the development of molecular biology: 1968 Nobel Prize laureates M. W. Nirenberg, H. G. Khorana, R. W. Holley [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2021
This review presents the life stories of M. Nirenberg, H. Khorana, and R. Holley, winners of the 1968 Nobel Prize in Physiology or Medicine, the history of the discoveries made by these scientists, and the methodological approaches used in their works ...
O. P. Matyshevska   +2 more
doaj   +1 more source

Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes [PDF]

open access: yesOpen Biology, 2017
RNA polymerase III (Pol III) transcribes a limited set of short genes in eukaryotes producing abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome appears to be expanding owing to the application of new methods.
Ewa Leśniewska, Magdalena Boguta
doaj   +1 more source

Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective

open access: yesRNA Biology, 2022
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
doaj   +1 more source

Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels [PDF]

open access: green, 1978
A method is described for indirect electron microscopic visualization and mapping of tRNA and other short transcripts hybridized to DNA. This method depends upon the attachment of the electron-dense protein ferritin to the RNA, the binding being mediated
Thomas R. Broker   +4 more
openalex   +4 more sources

Variance in translational fidelity of different bacterial species is affected by pseudouridines in the tRNA anticodon stem-loop

open access: yesRNA Biology, 2022
Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels.
Karl Jürgenstein   +5 more
doaj   +1 more source

On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes

open access: yesRNA Biology, 2023
Automated genome annotation is essential for extracting biological information from sequence data. The identification and annotation of tRNA genes is frequently performed by the software package tRNAscan-SE, the output of which is listed for selected ...
Peter T.S. van der Gulik   +7 more
doaj   +1 more source

Small regulatory RNAs: from bench to bedside – a keystone symposia meeting report

open access: yesRNA Biology, 2023
The Keystone Symposium ‘Small Regulatory RNAs: From Bench to Bedside’ was held in Santa Fe, New Mexico from May 1–4, 2022. The symposium was organized by Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt, and brought together scientists working
Soo Mi Lee   +3 more
doaj   +1 more source

Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code

open access: yesLife, 2020
Life on Earth and the genetic code evolved around tRNA and the tRNA anticodon. We posit that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to stabilize protocells. We posit that the initial amino acids to enter the
Lei Lei, Zachary F Burton
doaj   +1 more source

Complete mitochondrial genome sequence of Catla catla (Hamilton, 1822) from the Halda river of Bangladesh

open access: yesMitochondrial DNA. Part B. Resources, 2020
Catla (Catla catla) is one of the fastest-growing major carp found in South Asia as well as Bangladesh. Catla catla is the second most popular indigenous carp species in the freshwater aquaculture industry of Bangladesh due to its relatively good taste ...
M. M. Kibria   +5 more
doaj   +1 more source

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