Results 181 to 190 of about 185,424 (265)

The complete mitochondrial genome of <i>Anelytra</i> (<i>Anelytra</i>) <i>eunigrifrons</i> (Orthoptera, Tettigoniidae: Conocephalinae). [PDF]

Microbiol Resour Announc
Li G, Yu T, Bian X, Zhang B.
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, EarlyView.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Structure of ergosteryl-aspartate synthase reveals how an entrapped tRNA is used like a prosthetic swinging arm in the synthesis of aminoacylated sterols. [PDF]

Nat Commun
Murayama H, Yakobov N, Mahmoudi N, Legrosdidier S, Fournier N, Zuttion S, Matsumoto K, Nishimura M, Ji J, Senger B, Huck L, Gamper HB, Kise Y, Kleiner RE, Frechin M, Hou YM, Becker HD, Itoh Y, Fischer F, Nureki O.   +19 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Complete mitochondrial genome of <i>Eurhaphidophora fossa</i> (Orthoptera: Rhaphidophoridae: Rhaphidophorinae). [PDF]

Microbiol Resour Announc
Wang W, Yu T, Bian X, Zhang B.
europepmc   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao, Hiroshi Otsuka, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Fyzika a česká státní maturita ve světle francouzských zkušeností

Pedagogická Orientace, 2018
Josef Trna
doaj  

Substrate selectivity of the human RNA m⁵C methyltransferase NSUN2. [PDF]

Nature
Canepa J, Ruiz-Arroyo VM, Schlamowitz NS, Nam Y.   +3 more
europepmc   +1 more source