Results 161 to 170 of about 234,592 (250)

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Heat stress promotes pre-tRNA capping to modulate cap-dependent translation in Saccharomyces cerevisiae. [PDF]

Nat Commun
Kikuchi I, Ohira T, Nakatsuka T, Ishigami Y, Suzuki T.   +4 more
europepmc   +1 more source

tRNA-Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication. [PDF]

Cancer Sci
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Xitan W, Han L.
europepmc   +2 more sources

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, EarlyView.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

Involvement of tRNA thiolation in uORF-mediated translational regulation during Xylogenesis in Arabidopsis thaliana. [PDF]

Plant Cell Physiol
Nishii Y, Araki D, Saraumi M, Takahashi T.   +3 more
europepmc   +1 more source

Long-read, high-coverage reference genome of the nymphalid butterfly Catonephele acontius (Nymphalidae: Biblidinae). [PDF]

G3 (Bethesda)
Hicks M, Nhat Pham T, Seudre O, Escalante-Arteaga Z, S Knowles L, Gallice G, Oostra V.   +6 more
europepmc   +1 more source

Near‐T2T genome assembly of Erigeron sumatrensis provides insights into polyploid evolution and the herbicidal efficiency of HPPD inhibitors

New Plant Protection, EarlyView.
The near‐T2T genome assembly of Erigeron sumatrensis reveals an allohexaploid origin, evolution, and the interaction between the herbicidal target of the HPPD family and mesotrione. Abstract Species of Erigeron, members of the family Asteraceae, have invaded and adapted to agricultural fields and uncultivated habitats worldwide. Erigeron sumatrensis is
Yingying Wang, Jian Zhao, Jiao Zhang, Yaliang Shi, Xin Zhang, Feng Luo, Lianyang Bai, Meiliang Zhou, Zuren Li   +8 more
wiley   +1 more source

The complete mitochondrial genome of <i>Anelytra</i> (<i>Anelytra</i>) <i>hainanensis</i> (Orthoptera: Tettigoniidae: Conocephalinae). [PDF]

Microbiol Resour Announc
Liu N, Bian X, Zhang B.
europepmc   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

A call for unified use of human aminoacyl-tRNA synthetase (ARS) gene nomenclature. [PDF]

FEBS Lett
Antonellis A, Barrientos M, Bensasson E, DeClercq T, Garrigós P, Heilmann R, Horvath R, Magee D, Moresco A, Rowland A, Vallee I, Alexander R, Cui H, Gruić-Sovulj I, Hendrickson TL, Kim S, Ling J, Martinis SA, Musier-Forsyth K, Yang XL, Heinemann IU, Ribas de Pouplana L.   +21 more
europepmc   +1 more source