Results 11 to 20 of about 324,922 (336)
DEREGULATED EXPRESSIONS OF MYC ALTER THE EXPRESSIONS OF tRNAS IN BREAST CANCER CELLS
Sabiad, 2023 Objective: The protein synthesis process is started with DNA being transcribed into mRNA in the nucleus, then mRNA is transported to the cytoplasm and attaches to a ribosome in order to be translated into a protein.
Pervin Elvan Tokgün, Onur Tokgün
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On the mechanism of tRNA methylase-tRNA recognition [PDF]
Nucleic Acids Research, 1976 In order to further elucidate the mechanism of tRNA methylase-tRNA intreaction the methylation of some individual tRNAs separately and by pairs was performed. In conditions of tRNA excess the methylation rates of positionally analogous nucleotides in tRNA molecules are not summed up when two substrates are simultaneously present in the reaction mixture.
Alexander A. Bayev +2 more
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Compilation of tRNA sequences and sequences of tRNA genes [PDF]
Nucleic Acids Research, 1996 Maintained at the Universitat Bayreuth, Bayreuth, Germany, the Compilation of tRNA Sequences and Sequences of tRNA Genes is accessible at the URL http://www.tRNA.uni-bayreuth.de with mirror site located at the Institute of Protein Research, Pushchino, Russia (http://alpha.protres.ru/trnadbase).
M, Sprinzl +4 more
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Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code
Life, 2020 Life on Earth and the genetic code evolved around tRNA and the tRNA anticodon. We posit that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to stabilize protocells. We posit that the initial amino acids to enter the
Lei Lei, Zachary F Burton
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RNA Biology, 2022 Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels.
Karl Jürgenstein +5 more
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tRNA Recognition by Glutamyl-tRNA Reductase [PDF]
Journal of Biological Chemistry, 2004 During the first step of porphyrin biosynthesis in Archaea, most bacteria, and in chloroplasts glutamyl-tRNA reductase (GluTR) catalyzes the NADPH-dependent reduction of glutamyl-tRNA to glutamate-1-semialdehyde. Elements in tRNA(Glu) important for utilization by Escherichia coli GluTR were determined by kinetic analysis of 51 variant transcripts of E.
Stefan Schauer +9 more
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On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes
RNA Biology, 2023 Automated genome annotation is essential for extracting biological information from sequence data. The identification and annotation of tRNA genes is frequently performed by the software package tRNAscan-SE, the output of which is listed for selected ...
Peter T.S. van der Gulik +7 more
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From elongator tRNA to initiator tRNA. [PDF]
Proceedings of the National Academy of Sciences, 1993 We show that the two most important properties needed for a tRNA to function in initiation in Escherichia coli are its ability to be formylated and its ability to bind to the ribosomal P site. This conclusion is based on conversion of two different elongator tRNAs to ones that can act as initiators in E. coli.
Umesh Varshney +2 more
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tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation [PDF]
Frontiers in Genetics, 2020 tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life. Beyond translation control, tRFs have several functions ranging from transposon silencing to cell proliferation control.
Molla-Herman, Anahi +5 more
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Cysteinyl‐tRNA formation and prolyl‐tRNA synthetase [PDF]
FEBS Letters, 2002 Aminoacyl‐tRNA (AA‐tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA‐tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl‐tRNA (Cys‐tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl‐tRNA (Pro‐tRNA) synthetase, an ...
Dieter Söll +5 more
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