Results 11 to 20 of about 191,296 (315)
Methylated nucleosides in tRNA and tRNA methyltransferases [PDF]
Frontiers in Genetics, 2014 To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic pathways of the majority of tRNA modifications include a methylation step(s).
Hiroyuki eHori
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Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution [PDF]
Life, 2015 Transfer RNAs (tRNAs) are small non-coding RNAs with lengths of approximately 70–100 nt. They are directly involved in protein synthesis by carrying amino acids to the ribosome.
Akio Kanai
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Extracellular tRNAs and tRNA-derived fragments [PDF]
RNA Biology, 2020 Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising ...
Juan Pablo Tosar, Alfonso Cayota
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The dysregulation of tRNAs and tRNA derivatives in cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2018 Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but also tRNA derivatives generated by the specific cleavage of pre- and mature tRNAs in the progression of cancer.
Zongping Xiong +7 more
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Journal of Biological Chemistry, 1998 Introns interrupt the continuity of many eukaryal genes, and therefore their removal by splicing is a crucial step in gene expression. Interestingly, even within Eukarya there are at least four splicing mechanisms. mRNA splicing in the nucleus takes place in two phosphotransfer reactions on a complex and dynamic machine, the spliceosome.
Abelson, John +2 more
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On the mechanism of tRNA methylase-tRNA recognition [PDF]
Nucleic Acids Research, 1976 In order to further elucidate the mechanism of tRNA methylase-tRNA intreaction the methylation of some individual tRNAs separately and by pairs was performed. In conditions of tRNA excess the methylation rates of positionally analogous nucleotides in tRNA molecules are not summed up when two substrates are simultaneously present in the reaction mixture.
Alexander A. Bayev +2 more
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tRNA Recognition by Glutamyl-tRNA Reductase [PDF]
Journal of Biological Chemistry, 2004 During the first step of porphyrin biosynthesis in Archaea, most bacteria, and in chloroplasts glutamyl-tRNA reductase (GluTR) catalyzes the NADPH-dependent reduction of glutamyl-tRNA to glutamate-1-semialdehyde. Elements in tRNA(Glu) important for utilization by Escherichia coli GluTR were determined by kinetic analysis of 51 variant transcripts of E.
Stefan Schauer +9 more
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tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation [PDF]
Frontiers in Genetics, 2020 tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life. Beyond translation control, tRFs have several functions ranging from transposon silencing to cell proliferation control.
Molla-Herman, Anahi +5 more
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Compilation of tRNA sequences and sequences of tRNA genes [PDF]
Nucleic Acids Research, 1996 Maintained at the Universitat Bayreuth, Bayreuth, Germany, the Compilation of tRNA Sequences and Sequences of tRNA Genes is accessible at the URL http://www.tRNA.uni-bayreuth.de with mirror site located at the Institute of Protein Research, Pushchino, Russia (http://alpha.protres.ru/trnadbase).
M, Sprinzl +4 more
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From elongator tRNA to initiator tRNA. [PDF]
Proceedings of the National Academy of Sciences, 1993 We show that the two most important properties needed for a tRNA to function in initiation in Escherichia coli are its ability to be formylated and its ability to bind to the ribosomal P site. This conclusion is based on conversion of two different elongator tRNAs to ones that can act as initiators in E. coli.
Umesh Varshney +2 more
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