Results 11 to 20 of about 241,053 (344)
Noncanonical Roles of tRNAs: tRNA Fragments and Beyond
Annual Review of Genetics, 2020 As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well known for their role in reading the codons on messenger RNAs and translating them into proteins. In this review, we discuss the noncanonical functions of tRNAs.
Zhangli, Su +3 more
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The dysregulation of tRNAs and tRNA derivatives in cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2018 Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but also tRNA derivatives generated by the specific cleavage of pre- and mature tRNAs in the progression of cancer.
Shi-qiong Huang +7 more
openaire +4 more sources
Journal of Biological Chemistry, 1998 Introns interrupt the continuity of many eukaryal genes, and therefore their removal by splicing is a crucial step in gene expression. Interestingly, even within Eukarya there are at least four splicing mechanisms.
Abelson, John +2 more
core +4 more sources
Methylated nucleosides in tRNA and tRNA methyltransferases [PDF]
Frontiers in Genetics, 2014 To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic pathways of the majority of tRNA modifications include a methylation step(s).
Hiroyuki eHori
doaj +3 more sources
Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution [PDF]
Life, 2015 Transfer RNAs (tRNAs) are small non-coding RNAs with lengths of approximately 70–100 nt. They are directly involved in protein synthesis by carrying amino acids to the ribosome.
Akio Kanai
doaj +3 more sources
Extracellular tRNAs and tRNA-derived fragments [PDF]
RNA Biology, 2020 Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising ...
Juan Pablo Tosar, Alfonso Cayota
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Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Nature Biotechnology, 2023 Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is lacking.
M. Lucas +8 more
semanticscholar +1 more source
The tRNA identity landscape for aminoacylation and beyond
Nucleic Acids Research, 2023 tRNAs are key partners in ribosome-dependent protein synthesis. This process is highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases and relies primarily on sets of identities within tRNA molecules composed of ...
R. Giegé, G. Eriani
semanticscholar +1 more source
Nature Communications, 2022 Mis-regulated RNA modifications promote the processing and translation of oncogenic mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear. Here we reveal that tRNA m7G methyltransferase complex proteins METTL1 and WDR4 are
Hui Han +18 more
semanticscholar +1 more source
METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Clinical and Translational Medicine, 2021 Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood ...
Zhi-hang Chen +14 more
semanticscholar +1 more source