Results 221 to 230 of about 404,299 (351)

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

open access: yesInternational Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng   +4 more
wiley   +1 more source

HiFi based metagenomic assembly strategy provides accuracy near isolated genome resolution in MAG assembly

open access: yesiMetaOmics, EarlyView.
Recovering high‐contiguity, circular bacterial genomes from complex microbiomes (e.g., gut) is challenged by limitations of short‐read and error‐prone long‐read sequencing. This study comprehensively compares PacBio High‐Fidelity (HiFi) sequencing‐based metagenome‐assembled genomes (MAGs) against Illumina MAGs, Oxford Nanopore Technologies (ONT) MAGs ...
Feilong Deng   +7 more
wiley   +1 more source

Can geometric combinatorics improve RNA branching predictions? [PDF]

open access: yesBMC Bioinformatics
Poznanović S, Cardwell O, Heitsch C.
europepmc   +1 more source

Rapid reconstruction of multidrug‐resistant bacterial genomes using CycloneSEQ nanopore sequencing

open access: yesiMetaOmics, EarlyView.
Multidrug‐resistant (MDR) bacteria commonly harbor highly complex genomes enriched with mobile elements and resistance islands, which are challenging to resolve using short‐read sequencing. Here, we evaluated CycloneSEQ, a newly developed Chinese nanopore sequencing platform, for MDR genome reconstruction.
Kai Peng   +9 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami   +4 more
wiley   +1 more source

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