Results 221 to 230 of about 110,116 (296)

Pathogenic mechanism and therapeutic intervention of impaired N⁷-methylguanosine (m⁷G) tRNA modification. [PDF]

Proc Natl Acad Sci U S A
Ma J, Zheng S, An C, Han H, Li Q, Huang Y, Xiong G, Chen S, Guo S, Wang Z, Wei W, Shang Y, Ji Y, Yang C, Choe J, Yuan Q, Fan Y, Zhang C, Lin S.   +18 more
europepmc   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source

Charting new territory: The Plasmodium falciparum tRNA modification landscape. [PDF]

Biomed J
Lee BST, Sinha A, Dedon P, Preiser P.
europepmc   +1 more source

tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory

, 2023
Madhwani KR, Sayied S, Ogata CH, Hogan CA, Lentini JM, Mallik M, Dumouchel JL, Storkebaum E, Fu D, O’Connor-Giles KM.   +9 more
europepmc   +1 more source

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. [PDF]

Nat Microbiol
Small-Saunders JL, Sinha A, Bloxham TS, Hagenah LM, Sun G, Preiser PR, Dedon PC, Fidock DA.   +7 more
europepmc   +1 more source

Decoding Dual Regulatory Layers: Integrating Differential Expression and Alternative Splicing Dynamics in the Evolution of Laryngeal Echolocation Across Chiropteran Lineages

Integrative Zoology, EarlyView.
We integrated short‐read and long‐read RNA‐seq data from cochlear tissues of echolocating and non‐echolocating bats to disentangle transcriptional and post‐transcriptional regulation. Echolocating bats showed neural‐function enrichment among differentially expressed genes, while alternatively spliced genes were linked to epigenetic regulation. Overlaps
Jianyu Wu, Daoyuan Hu, Min Chen, Xiuguang Mao   +3 more
wiley   +1 more source

Impairing protein-protein interactions in an essential tRNA modification complex: An innovative antimicrobial strategy against Pseudomonas aeruginosa. [PDF]

J Pept Sci
Bollati M, Fasola E, Pieraccini S, Freddi F, Cocomazzi P, Oliva F, Klußmann M, Maspero A, Piarulli U, Ferrara S, Pellegrino S, Bertoni G, Gazzola S.   +12 more
europepmc   +1 more source

Nest Survival Models and Genomics Illuminate Hybridisation Attempts, Guiding Culturally Informed Management to Recover a Critically Endangered Seabird

Animal Conservation, EarlyView.
Long‐term monitoring has revealed hybridisation attempts between the Critically Endangered Kuaka Whenua Hou (KWH, Pelecanoides whenuahouensis) and the abundant Kuaka (P. urinatrix). Here we use modelling based on population monitoring data in tandem with genomic data to investigate these attempts and the risk they pose to KWH recovery.
N. J. Forsdick, T. R. Buckley, T. Davis, I. Debski, J. H. Fischer   +4 more
wiley   +1 more source