Results 51 to 60 of about 5,994 (219)

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

A Survey on the Design, Detection, and Prevention of Pre-Silicon Hardware Trojans

IEEE Access
The complexity of the semiconductor design lifecycle and globalized manufacturing process creates concern over the threat of deliberate malicious alterations, or hardware Trojans, being inserted into microelectronic designs.
Jonathan Cruz, Jason Hamlet
doaj   +1 more source

Smart Hardware Trojan Detection System

, 2022
The IoT has become an indispensable part of human lives at work and home applications. Due to the need for an enormous number of IoT devices manufacturers are least concerned about security vulnerabilities during designing and developing of these devices.
Iyad Alkhazendar, Mohammed Zubair, Uvais Qidwai   +2 more
openaire   +2 more sources

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

AVATAR: NN-Assisted Variation Aware Timing Analysis and Reporting for Hardware Trojan Detection

IEEE Access, 2021
This paper presents AVATAR, a learning-assisted Trojan testing flow to detect hardware Trojans placed into fabricated ICs at an untrusted foundry, without needing a Golden IC.
Ashkan Vakil, Ali Mirzaeian, Houman Homayoun, Naghmeh Karimi, Avesta Sasan   +4 more
doaj   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

BMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu, Baoqin Song, Zhihao Chen, Wenzhong Li, Wanjun Liang, Xiu Wang   +5 more
wiley   +1 more source

Trojan playground: a reinforcement learning framework for hardware Trojan insertion and detection

The Journal of Supercomputing
Current Hardware Trojan (HT) detection techniques are mostly developed based on a limited set of HT benchmarks. Existing HT benchmark circuits are generated with multiple shortcomings, i.e., i) they are heavily biased by the designers' mindset when created, and ii) they are created through a one-dimensional lens, mainly the signal activity of nets.
Amin Sarihi, Ahmad Patooghy, Peter Jamieson, Abdel-Hameed A. Badawy   +3 more
openaire   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Hybrid multi‐level hardware Trojan detection platform for gate‐level netlists based on XGBoost

IET Computers & Digital Techniques, 2022
Coping with the problem of malicious third‐party vendors implanting Hardware Trojan (HT) in the circuit design stage, this paper proposes a hybrid‐mode gate‐level hardware Trojan detection platform based on the XGBoost algorithm.
Ying Zhang, Sen Li, Xin Chen, Jiaqi Yao, Zhiming Mao, Jizhong Yang, Yifeng Hua   +6 more
doaj   +1 more source