Results 1 to 10 of about 2,124 (179)

Detachment of Hexokinase II From Mitochondria Promotes Collateral Sensitivity in Multidrug Resistant Chronic Myeloid Leukemia Cells

Frontiers in Oncology, 2022
Chronic Myeloid Leukemia is a neoplastic disease characterized by the abnormal expansion of hematopoietic cells with compromised functions. Leukemic cells often display a multidrug resistance phenotype, enabling them to evade a number of structurally ...
Thaís Oliveira, Douglas Lemos, Louise Jean, Jéssica M. Kawashima, Vitória R. de Azevedo, Eduardo J. Salustiano, Vivian M. Rumjanek, Robson Q. Monteiro   +7 more
doaj   +1 more source

Inflammatory and Hemostatic Markers in COVID-19 Patients with Arterial Thrombosis Are Significantly Lower at Hospital Admission than in COVID-19 Patients without Thrombosis

Viruses, 2022
Patients with Coronavirus disease 2019 (COVID-19) are at increased risk of venous thromboembolism (VTE); however, data on arterial thromboembolism (ATE) is still limited.
Miguel de Oliveira, Francisco Cubal, Maria Coutinho, Mónica Pereira, Eugénia Cruz, Sara Morais   +5 more
doaj   +1 more source

MAIN BLOOD SERUM METABOLITES RESPONSIBLE FOR THE DISCRIMINATION OF HOSPITALIZED PATIENTS WITH MODERATE SYMPTOMS WITH OR WITHOUT COVID-19

Hematology, Transfusion and Cell Therapy, 2021
Introduction: The variation in human blood serum metabolites resulting from an infection can assist in understanding mechanisms of pathogen action and body response and improve diagnosis. Aim: To map serum signatures of hospitalized symptomatic patients,
LG Martins, SS Martins, ES Braga, D Stanisic, SAL Montalvão, LQ Silva, SC Huber, T Diaz, C Wroclawski, CC Filho, L Tasic, JM Annichino-Bizzacchi   +11 more
doaj   +1 more source

TROMBOSE VENOSA PORTAL EM TRANSPLANTAÇÃO HEPÁTICA – NOSSOS RESULTADOS E TÉCNICA CIRÚRGICA

Brazilian Journal of Transplantation, 2021
Introdução: Transplante de fígado ainda é um desafio cirúrgico, principalmente nos casos de trombose da veia porta. Enquanto alguns doentes em lista para transplante hepático são diagnosticados com essa condição no pré-operatório, outros são detetados ...
Nádia Silva, João Santos Coelho, Hugo Pinto Marques, Américo Martins   +3 more
doaj   +1 more source

A new case of platelet‐type von Willebrand disease supports the recent findings of gain‐of‐function GP1BA variants outside the C‐terminal disulphide loop enhances affinity for von Willebrand factor

British Journal of Haematology, Volume 203, Issue 4, Page 673-677, November 2023., 2023
Summary Platelet‐type von Willebrand disease (PT‐VWD) is a rare autosomal dominant bleeding disorder characterized by an increased ristocetin‐induced platelet aggregation (RIPA) and enhanced affinity of platelet glycoprotein Ibα (GPIbα) to von Willebrand factor (VWF).
Catarina Monteiro, Ana Gonçalves, Mónica Pereira, Catarina Lau, Sara Morais, Rosário Santos   +5 more
wiley   +1 more source

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate

Journal of Thrombosis and Haemostasis, Volume 19, Issue 5, Page 1348-1363, May 2021., 2021
Abstract Introduction Vitamin K antagonists (VKA) and non‐vitamin K oral antagonist anticoagulants (NOAC) are used in the clinic to reduce risk of thrombosis. However, they also exhibit vascular off‐target effects. The aim of this study is to compare VKA and NOAC on atherosclerosis progression and calcification in an experimental setup.
Rick H. van Gorp, Ingrid Dijkgraaf, Vanessa Bröker, Matthias Bauwens, Peter Leenders, Danyel Jennen, Marc R. Dweck, Jan Bucerius, Jacco J. Briedé, Joanne van Ryn, Vincent Brandenburg, Felix Mottaghy, Henri M. H. Spronk, Chris P. Reutelingsperger, Leon J. Schurgers   +14 more
wiley   +1 more source

Diagnóstico e manejo de isquemia aguda de membro em paciente pós infecção viral por covid-19: série de casos

Jornal Vascular Brasileiro, 2022
Resumo A pandemia causada pela doença do coronavírus 2019 (covid-19) estabeleceu desafios e estimulou o desenvolvimento de diferentes formas terapêuticas em várias áreas médicas.
Jamisson Garrote Teixeira, Guilherme Benjamin Brandão Pitta, Cézar Ronaldo Alves da Silva, Lucigl Regueira Teixeira, Gregório Luís Guarnieri Panazzolo, Joaquim Araújo Sampaio, Anna Karoline Rocha de Sousa, Claubiano Cipriano Moura   +7 more
doaj   +2 more sources

Síndrome de imunização antifosfolipídica e trombose.

Acta Médica Portuguesa, 1994
The designation of Antiphospholipid Syndrome was first applied by Harris in 1987, to a clinical status characterized by the detection of anticardiolipin and/or lupus anticoagulant with clinical thromboembolic manifestations.
J C de Sousa, F Carriço
doaj   +1 more source

Barriers to blood donation on social media: An analysis of Facebook and Twitter posts

Transfusion, Volume 60, Issue 10, Page 2294-2306, October 2020., 2020
Abstract Background To better understand donor behavior and ensure a safe and sufficient blood supply, various observational studies have examined barriers to blood donation. This study used Facebook and Twitter data to enhance existing research on donation barriers and associated emotions communicated on social media by both donors and non‐donors ...
Steven Ramondt, Melissa Zijlstra, Peter Kerkhof, Eva‐Maria Merz   +3 more
wiley   +1 more source

Y‐RNA subtype ratios in plasma extracellular vesicles are cell type‐ specific and are candidate biomarkers for inflammatory diseases

Journal of Extracellular Vesicles, Volume 9, Issue 1, September 2020., 2020
ABSTRACT Major efforts are made to characterize the presence of microRNA (miRNA) and messenger RNA in blood plasma to discover novel disease‐associated biomarkers. MiRNAs in plasma are associated to several types of macromolecular structures, including extracellular vesicles (EV), lipoprotein particles (LPP) and ribonucleoprotein particles (RNP).
Tom A.P. Driedonks, Sanne Mol, Sanne de Bruin, Anna‐Linda Peters, Xiaogang Zhang, Marthe F.S. Lindenbergh, Boukje M. Beuger, Anne‐Marieke D. van Stalborch, Thom Spaan, Esther C. de Jong, Erhard van der Vries, Coert Margadant, Robin van Bruggen, Alexander P.J. Vlaar, Tom Groot Kormelink, Esther N.M. Nolte‐‘T Hoen   +15 more
wiley   +1 more source