ABSTRACT Objective To compare the trajectories of placental biomarkers throughout pregnancy after aspirin discontinuation at 24–28 weeks with those of a cohort treated until 36 weeks of gestation. Design A longitudinal secondary analysis of the StopPRE trial, using repeated measures of soluble fms‐like tyrosine kinase‐1 (sFlt‐1), placental growth ...
Erika Bonacina +29 more
wiley +1 more source
Melatonin mitigates Autophagy: Unlocking Conditional Resilience in Sheep Trophoblast Cells Exposed to a Hypoxic Environment. [PDF]
Viola I +7 more
europepmc +1 more source
DcR3, stabilized by the RNA-binding protein IGF2BP2, promotes proliferation, invasion, and migration of trophoblast cells and facilitates angiogenesis. [PDF]
Zhao P, Li D, Liu X.
europepmc +1 more source
The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen +18 more
wiley +1 more source
Cross-species identification of conserved cell-type specific mechanisms during early placenta development in ruminants. [PDF]
Leavitt ML +5 more
europepmc +1 more source
Repression of Major Histocompatibility Complex Genes by a Human Trophoblast Ribonucleic Acid [PDF]
John A. Peyman
openalex +1 more source
Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes
ABSTRACT Background Epidemiological studies have reported an association between advanced paternal age at conception and an increased risk of neurodevelopmental disorders in offspring, such as autism spectrum disorder. Evidence suggests that DNA methylation alterations in spermatozoa of older men may be transmitted to the feto‐placental unit and ...
Julia Barnwell +12 more
wiley +1 more source
The Etiopathogenesis of Preeclampsia: Where Do We Stand Now? [PDF]
Laskowska M, Bednarek A, Stworowski M.
europepmc +1 more source

