Results 141 to 150 of about 3,985 (199)

Progress of immunotherapies in gestational trophoblastic neoplasms

Journal of Cancer Research and Clinical Oncology, 2023
Different from other malignant gynecologic tumors, gestational trophoblastic neoplasms (GTNs) exhibit an exceptionally high cure rate primarily through chemotherapeutic interventions. However, there exists a small subset of refractory GTNs that do not respond to conventional chemotherapies.
Tong Wang, Wenxiu Guo, Xiaochen Ren, Fangfang Lang, Ying Ma, Chunping Qiu, Jie Jiang   +6 more
openaire   +2 more sources

Gestational trophoblastic neoplasms

Gynecologic Oncology, 1974
A review of the classification, biological behavior, clinical diagnosis, and treatment of gestational trophoblastic neoplasms is presented. The events which followed the utilization of chemotherapy as a successful means of therapy are included. Especially important has been the recent recognition that high risk patients, i.e., patients with HCG titers ...
Robert D. Hilgers, John L. Lewis
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Gestational Trophoblastic Neoplasms

Journal of Obstetric, Gynecologic & Neonatal Nursing, 1986
Gestational trophoblastic neoplasms have evolved from one of the most rapidly fatal malignancies to potentially one of the most curable, but these diseases have devastating emotional effects on the victims. Etiology, epidemiology, pathophysiology, diagnosis, and medical treatment are reviewed.
Sonya M. Celeste, Maureen D. Smith
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PREGNANCIES AFTER CHEMOTHERAPY OF TROPHOBLASTIC NEOPLASMS

Obstetrical & Gynecological Survey, 1970
We have analyzed 88 pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used.
Griff T. Ross, David H. Van Thiel, Mortimer B. Lipsett   +2 more
openaire   +4 more sources

Genetic origin of malignant trophoblastic neoplasms

Cancer Genetics and Cytogenetics, 1994
The genetic origin of three trophoblastic neoplasms (two choriocarcinomas and a placental site trophoblast tumor (PSTT)] was determined by analysis of the restriction fragment length polymorphism (RFLP) pattern. One choriocarcinoma, which was believed not illogically to have developed from an antecedent complete mole, contained both paternal and ...
Masazumi Tsuneyoshi, Norio Wake, Satoshi Amada, Takahiro Arima, Toshiro Imamura   +4 more
openaire   +3 more sources

Intermediate Trophoblast in Germ Cell Neoplasms

The American Journal of Surgical Pathology, 1987
One-hundred-twenty-four germ cell tumors and 11 gestational choriocarcinomas were assessed immunohistochemically for the presence of the following placental markers: human chorionic gonadotrophin, human placental lactogen, and pregnancy-specific beta-1 glycoprotein, and for the expression of cytokeratin.
G. Niehans, Mark R. Wick, J C Manivel, Louis P. Dehner   +3 more
openaire   +3 more sources

Primary chemotherapy for nonmetastatic gestational trophoblastic neoplasms

American Journal of Obstetrics and Gynecology, 1967
Abstract This report summarizes our 7 years' experience in the methotrexate chemotherapy of 58 patients with nonmetastatic gestational trophoblastic neoplasms. Of these patients, 54 (93 per cent) entered sustained complete remission. Three of the remaining 4 patients with methotrexate-resistant disease later entered remission with either hysterectomy
Griff T. Ross, William D. Odell, Mortimer B. Lipsett, Roy Hertz, Charles B. Hammond   +4 more
openaire   +3 more sources

Modified Bagshawe Regimen for Gestational Trophoblastic Neoplasms [PDF]

Hospital Pharmacy, 2006
The increasing complexity of cancer chemotherapy heightens the requirement that pharmacists be familiar with these highly toxic agents. This column will review various issues related to preparation, dispensing, and administration of cancer chemotherapy.
J. Aubrey Waddell, Michael S. Edwards, Dominic A. Solimando   +2 more
openaire   +1 more source

Gestational Trophoblastic Neoplasms:

Obstetrics and Gynecology Clinics of North America, 1988
Gestational trophoblastic neoplasms have been recognized since 1600 AD. This article briefly reviews the history of this distinctive disease and highlights some interesting features.
openaire   +3 more sources