Results 261 to 270 of about 40,342 (338)

Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
The study reports that Wnt inhibitors safeguard porcine embryonic stem cells (ESCs) from acquiring the extraembryonic endoderm (XEN) lineage, and further develop an efficient strategy to derive XEN cells from ESCs. The XEN cells from ESCs exhibit similar transcriptome and chromatin accessibility features to XEN cells from embryos and contribute to ...
Hanning Wang   +4 more
wiley   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng   +8 more
wiley   +1 more source

Generation of Bona Fide Human Induced Trophoblast Stem Cells by Direct Reprogramming of Term Umbilical Cord Cells. [PDF]

open access: yesInt J Mol Sci
van Voorden AJ   +6 more
europepmc   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

open access: yesAdvanced Science, Volume 12, Issue 18, May 15, 2025.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao   +16 more
wiley   +1 more source

BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome. [PDF]

open access: yesFront Immunol
Zhao M   +9 more
europepmc   +1 more source

Immunology of Trophoblast [PDF]

open access: yesJournal of Clinical Pathology, 1976
openaire   +2 more sources

Induction of Cell Death by Combined Treatment with Photosensitizer‐Chitosan Nanoparticles and the Ferroptosis Inducer RSL3 in Breast Cancer Cell Lines

open access: yesAdvanced NanoBiomed Research, Volume 5, Issue 5, May 2025.
This study demonstrates that combination of phosphosensitizer‐conjugated chitosan nanoparticles and ferroptosis inducer RSL3 increases cell death in mesenchymal breast cancer cells. Data suggests that this is attributed to variations in ferroptosis‐related protein expression, lipid peroxydation and mitochondrial function.
Marek Feith   +10 more
wiley   +1 more source

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