Results 31 to 40 of about 14,370 (182)

Balamuthia mandrillaris trophozoites ingest human neuronal cells via a trogocytosis-independent mechanism

Parasites & Vectors, 2022
Background Environmental protozoa need an adaptation mechanism to survive drastic changes in niches in the human body. In the brain parenchyma, Balamuthia mandrillaris trophozoites, which are causative agents of fatal brain damage, must acquire nutrients
Worakamol Pengsart, Nongnat Tongkrajang, Narisara Whangviboonkij, Patsharaporn Techasintana Sarasombath, Kasem Kulkeaw   +4 more
doaj   +1 more source

Investigation of the anti-parasitic effect of the water extract of Thymbra spicata on Acanthamoeba castellani (L.) trophozoites and cysts

International Journal of Plant Based Pharmaceuticals, 2021
This study aimed to determine the anti-parasitic activity of the water extract obtained from Thymbra spicata (L.). The plant material was extracted with methanol in a Soxhlet apparatus. The extract was then fractionated with water and chloroform.
Baris Gulec, Duhan Tore, Arzuhan Sihoglu Tepe, Ibrahim Halil Kilic   +3 more
doaj  

Providing an in vitro depiction of microglial cells challenged with immunostimulatory extracellular vesicles of Naegleria fowleri

Frontiers in Microbiology
Naegleria fowleri is the causative agent of primary amoebic meningoencephalitis, a rapid and acute infection of the central nervous system with a fatal outcome in >97% of cases. Due to the infrequent report of cases and diagnostic gaps that hinder the
Lissette Retana Moreira, Lissette Retana Moreira, Alberto Cornet-Gomez, M. Rosario Sepulveda, Silvia Molina-Castro, Silvia Molina-Castro, Johan Alvarado-Ocampo, Frida Chaves Monge, Mariana Jara Rojas, Antonio Osuna, Elizabeth Abrahams Sandí, Elizabeth Abrahams Sandí   +11 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Epithelial Cells Expressing EhADH, An Entamoeba histolytica Adhesin, Exhibit Increased Tight Junction Proteins

Frontiers in Cellular and Infection Microbiology, 2018
In Entamoeba histolytica, the EhADH adhesin together with the EhCP112 cysteine protease, form a 124 kDa complex named EhCPADH. This complex participates in trophozoite adherence, phagocytosis and cytolysis of target cells.
Abigail Betanzos, Abigail Betanzos, Dxinegueela Zanatta, Cecilia Bañuelos, Elizabeth Hernández-Nava, Patricia Cuellar, Esther Orozco   +6 more
doaj   +1 more source

Potential anti-Acanthamoeba and anti-adhesion activities of Annona muricata and Combretum trifoliatum extracts and their synergistic effects in combination with chlorhexidine against Acanthamoeba triangularis trophozoites and cysts

Heliyon, 2021
Plants with medicinal properties have been used in the treatment of several infectious diseases, including Acanthamoeba infections. The medicinal properties of Cambodian plant extracts; Annona muricata and Combretum trifoliatum were investigated against ...
Watcharapong Mitsuwan, Chea Sin, Samell Keo, Suthinee Sangkanu, Maria de Lourdes Pereira, Tajudeen O. Jimoh, Cristina C. Salibay, Muhammad Nawaz, Roghayeh Norouzi, Abolghasem Siyadatpanah, Christophe Wiart, Polrat Wilairatana, Polydor Ngoy Mutombo, Veeranoot Nissapatorn   +13 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Reproductive Morphometric Plasticity in Gregarina polymorpha Infecting Tenebrio molitor Larvae

Journal of Eukaryotic Microbiology, Volume 73, Issue 5, September/October 2026.
ABSTRACT Morphological variability remains one of the principal challenges in the taxonomy and species delimitation of gregarines (Apicomplexa: Gregarinomorphea). In the present study, we investigated morphometric variability in gametocysts and syzygies of Gregarina polymorpha infecting Tenebrio molitor larvae through quantitative morphometric and ...
Alejandro Javier Correa‐Espinosa, Gregorio Pérez‐Cordón   +1 more
wiley   +1 more source

Identifying Molecular Changes in Giardia lamblia Stages Using Hyperspectral Raman Microscopy

Diagnostics
Background/Objectives: Giardiasis is one of the oldest-reported infectious diseases worldwide. It affects individuals with weakened immune systems and progresses into chronic infection if untreated. Morphological analysis and visualization of cell shapes
Felicia S. Manciu, Breanna C. Pence, Blessing A. Ibechenjo, Marian Manciu, Sudhir Bhattarai, Siddhartha Das   +5 more
doaj   +1 more source

Entamoeba histolytica: Adhesins and Lectins in the Trophozoite Surface [PDF]

Molecules, 2015
Entamoeba histolytica is the causative agent of amebiasis in humans and is responsible for 100,000 deaths annually, making it the third leading cause of death due to a protozoan parasite. Pathogenesis appears to result from the potent cytotoxic activity of the parasite, which kills host cells within minutes.
Magdalena Aguirre García, Laila Gutiérrez-Kobeh, Rosario López Vancell   +2 more
openaire   +3 more sources