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Early-Onset HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis [PDF]

Pathogens, 2020
Background: Vertical transmission of HTLV-1 could lead to the early development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This significantly affects quality of life and increases morbimortality.
Alvaro Schwalb, Valeria Pérez-Muto, Rodrigo Cachay, Martín Tipismana, Carolina Álvarez, Fernando Mejía, Elsa González-Lagos, Eduardo Gotuzzo   +7 more
doaj   +7 more sources

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis [PDF]

Frontiers in Microbiology, 2019
Human T-lymphotropic virus type 1 (HTLV-1) is the etiologic agent of both adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Satoshi Nozuma, Steven Jacobson
doaj   +5 more sources

Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1-associated myelopathy/tropical spastic paraparesis. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance HTLV-1 manifests many diseases, which cause morbidity and mortality in 5∼10% of infected individuals, including the fatal adult T cell leukemia/lymphoma (ATLL) and debilitating myelopathy (HAM/TSP).
Nagasaka M, Yamagishi M, Yagishita N, Araya N, Kobayashi S, Makiyama J, Kubokawa M, Yamauchi J, Hasegawa D, Coler-Reilly ALG, Tsutsumi S, Uemura Y, Arai A, Takata A, Inoue E, Hasegawa Y, Watanabe T, Suzuki Y, Uchimaru K, Sato T, Yamano Y.   +20 more
europepmc   +4 more sources

Tropical spastic paraparesis in Northeastern Brazil [PDF]

Arquivos de Neuro-Psiquiatria, 1989
Ten possible cases of tropical spastic paraparesis (TSP) in Northeastern Brazil (Ceará) are presented. They show the typical symptoms and signs of TSP consisting of weakness of the lower limbs, spastic gait, hiperreflexia, bladder dysfunction and ...
C. M. de Castro Costa, M. R. Salgueiro, H. Carton, O. C. do Vale, A. M. de Arruda   +4 more
doaj   +6 more sources

Immunopathogenesis and Cellular Interactions in Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis. [PDF]

Front Microbiol, 2020
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neuropathological disorder in 1–3% of individuals infected with Human T-lymphotropic virus 1 (HTLV-1). This condition is characterized by progressive spastic lower limb weakness and
Aghajanian S, Teymoori-Rad M, Molaverdi G, Mozhgani SH.   +3 more
europepmc   +3 more sources

Balance assessment in HTLV-1 associated myelopathy or tropical spastic paraparesis [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: A good rating of the device in people with HTLV-1 in this population is essential for accuracy in prescribing data (walking). Thus, this study aimed to analyze the counterpart assessment methods that are best suited to patients with human T-
Naiane Araújo Patrício, Mônica Andrade Rios, Patrícia Carvalho Barbosa, Jéssica Ramos Ribeiro, Diogo Guedes Vidal, Kátia Nunes Sá, Abrahão Fontes Baptista   +6 more
doaj   +3 more sources

Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population. [PDF]

Proc Natl Acad Sci U S A, 2021
Significance Human T cell leukemia virus type 1 (HTLV-1) proviral load is associated with the risk of developing HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) and several small-scale candidate gene approaches have also identified ...
Penova M, Kawaguchi S, Yasunaga JI, Kawaguchi T, Sato T, Takahashi M, Shimizu M, Saito M, Tsukasaki K, Nakagawa M, Takenouchi N, Hara H, Matsuura E, Nozuma S, Takashima H, Izumo S, Watanabe T, Uchimaru K, Iwanaga M, Utsunomiya A, Tabara Y, Paul R, Yamano Y, Matsuoka M, Matsuda F.   +24 more
europepmc   +2 more sources

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) versus adult T-cell leukemia/lymphoma (ATLL). [PDF]

BMC Res Notes, 2021
Human T cell leukemia virus-1 (HTLV-1) infection may lead to one or both diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T cell leukemia lymphoma (ATLL).
Zarei-Ghobadi M, Sheikhi M, Teymoori-Rad M, Yaslianifard S, Norouzi M, Yaslianifard S, Faraji R, Farahmand M, Bayat S, Jafari M, Mozhgani SH.   +10 more
europepmc   +2 more sources

Tropical spastic paraparesis – anesthetic approach

Brazilian Journal of Anesthesiology, 2017
Introduction: HTLV-1 infection is endemic in Japan, Caribbean, Africa, and South America. It is transmitted from mother to child, sexual contact, blood transfusions, or sharing needles.
Margarida Rodrigues, Francisco Cabral, Fátima Pina   +2 more
doaj   +7 more sources

Anti-Human T-Cell Leukemia Virus Type 1 (HTLV-1) Antibody Assays in Cerebrospinal Fluid for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. [PDF]

J Clin Microbiol, 2021
The anti-human T-cell leukemia virus type 1 (HTLV-1) antibody assay in common use has changed from the particle agglutination (PA) method to chemiluminescent immunoassay (CLIA) and chemiluminescent enzyme immunoassay (CLEIA).
Kodama D, Tanaka M, Matsuzaki T, Nozuma S, Matsuura E, Takashima H, Izumo S, Kubota R.   +7 more
europepmc   +2 more sources