Results 41 to 50 of about 14,095 (132)

The effect of 1% tropicamide on central corneal thickness and intraocular pressure

African Vision and Eye Health
Background: Dilating the eye with tropicamide may alter the intraocular pressure (IOP) because of an obstruction of the iridocorneal angle, resulting in decreased aqueous outflow drainage.
Dimakatso G. Mashala, Bevily Nukeri, Alpheus S. Phaka, Angela N. Mashabu, Mlungisi J. Fakude, Phillip M. Seabi, Matome Mmakgaha, Ramadimetja P. Sedibeng   +7 more
doaj   +1 more source

Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs

Frontiers in Pharmacology, 2020
The breakdown of blood-tear barrier that occurs with ocular pathology allows for large amounts of albumin to leak into the tear fluid. This process likely represents an important restriction to drug absorption in ophthalmology, as only the unbound drug ...
Lionel Sebbag, Lionel Sebbag, Leah M. Moody, Jonathan P. Mochel   +3 more
doaj   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Murine Biocompatibility Evaluation of an Albumin‐Derived Complex and Nanoparticle Delivery System for Ocular Applications

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Age‐related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late‐stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections.
Amna Abdalbaqi, Nagaraj Kerur, Matthew P. Ohr, Andre F. Palmer, Katelyn E. Swindle‐Reilly   +4 more
wiley   +1 more source

Effectiveness of cyclopentolate 1% compared to the combination of cyclopentolate 1%, tropicamide 1%, and phenylephrine 10% in cycloplegic refractive examination

Journal of Clinical Ophthalmology and Research
Context: Refractive errors in children require appropriate eyeglass correction. Cycloplegic refraction is a method used to determine eyeglass prescriptions in children due to their high accommodative power.
Marina Dewi Fitriyani, Sawitri Boengas, Jefman Efendi Marzuki, Saraswati Retno Gumilang   +3 more
doaj   +1 more source

Dynamic Retinal Pathology in Glaucoma Progression Revealed by High‐Resolution Functional Imaging In Vivo

Laser &Photonics Reviews, Volume 20, Issue 5, 6 March 2026.
In this work, we investigated the dynamic retinal pathology of glaucoma from onset to late stages through longitudinal in vivo high‐resolution imaging in a silicone oil‐induced ocular hypertension (SOHU) glaucoma mouse model. We developed an optimized adaptive optics two‐photon excitation fluorescence microscopy (AO‐TPEFM) technique for morphological ...
Yiming Fu, Pham Binh Minh, Sicong He, Yingzhu He, Zhongya Qin, Ting Xie, Jianan Qu   +6 more
wiley   +1 more source

Evaluating the Potentiating Effect of Amethocaine on Tropicamide-Induced Mydriasis in Darkly Pigmented Irides, Using Infrared Pupillometry

Ophthalmology and Eye Diseases, 2014
Purpose To determine whether prior instillation of amethocaine would increase the rate and magnitude of tropicamide-induced pupillary dilatation in darkly pigmented irides.
Olufunmilola A. Ogun, Jeffrey W. Oliver, Adeyinka O. Ashaye, Benedictus G. K. Ajayi   +3 more
doaj   +1 more source

Cycloplegia Improves the Inter-Optometrist Repeatability of Subjective Refraction

Photonics
Background: Since accommodation may be a source of error affecting the inter-optometrist repeatability of subjective refraction, this study investigated whether the use of cycloplegia could improve this repeatability.
Carlos Carpena-Torres, Maria Rodríguez-Lafora, Cristina Pastrana, Ana Privado-Aroco, María Serramito, Laura Batres, Gonzalo Carracedo   +6 more
doaj   +1 more source

Comparison of cyclopentolate versus tropicamide cycloplegia: A systematic review and meta-analysis

Journal of Optometry, 2018
Purpose: The aim of the present meta-analysis is to compare the efficacy of cyclopentolate and tropicamide in controlling accommodation during refraction. Methods: A comprehensive literature search was performed in PubMed, Scopus, Science direct and Ovid
Negareh Yazdani, Ramin Sadeghi, Hamed Momeni-Moghaddam, Leili Zarifmahmoudi, Asieh Ehsaei   +4 more
doaj   +1 more source

Single oral administration of dronabinol increases ocular blood flow in patients with glaucoma

Acta Ophthalmologica, Volume 104, Issue 2, Page 225-232, March 2026.
Abstract Purpose Glaucoma is a leading cause of irreversible blindness globally, primarily driven by elevated intraocular pressure (IOP). Still, some patients progress despite significant IOP lowering, potentially due to impaired ocular blood flow. This study aimed to evaluate the effects of dronabinol, a synthetic tetrahydrocannabinol derivative, on ...
Theresa Lindner, Viktoria Pai, Patrick Janku, Nikolaus Hommer, Anton Hommer, Marihan Abensperg‐Traun, Liudmyla Petric, Leopold Schmetterer, Gerhard Garhöfer, Doreen Schmidl   +9 more
wiley   +1 more source