Results 71 to 80 of about 19,573 (216)

Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. [PDF]

, 2020
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events.
Bhargava, Raag, Gao, Mei Hua, Giamouridis, Dimosthenis, Guo, Tracy, Hammond, H Kirk, Huu, Viet Anh Nguyen, Kim, Young Chul, Lai, N Chin, Lantier, Louise, Skowronska-Krawczyk, Dorota, Xia, Bing   +10 more
core  

Single oral administration of dronabinol increases ocular blood flow in patients with glaucoma

Acta Ophthalmologica, Volume 104, Issue 2, Page 225-232, March 2026.
Abstract Purpose Glaucoma is a leading cause of irreversible blindness globally, primarily driven by elevated intraocular pressure (IOP). Still, some patients progress despite significant IOP lowering, potentially due to impaired ocular blood flow. This study aimed to evaluate the effects of dronabinol, a synthetic tetrahydrocannabinol derivative, on ...
Theresa Lindner, Viktoria Pai, Patrick Janku, Nikolaus Hommer, Anton Hommer, Marihan Abensperg‐Traun, Liudmyla Petric, Leopold Schmetterer, Gerhard Garhöfer, Doreen Schmidl   +9 more
wiley   +1 more source

Repeatability of retinal vessel flicker responses in healthy individuals

Acta Ophthalmologica, Volume 104, Issue 2, Page e165-e172, March 2026.
Abstract Purpose To determine the repeatability of retinal blood vessel parameters (from proprietary software and the raw vessel data) measured in vivo in healthy individuals at rest, during and post flicker light (FL) provocation using a standardised protocol.
Angelos Kalitzeos, Robert J. Summers, Rebekka Heitmar   +2 more
wiley   +1 more source

The effect of 1% tropicamide on central corneal thickness and intraocular pressure

African Vision and Eye Health
Background: Dilating the eye with tropicamide may alter the intraocular pressure (IOP) because of an obstruction of the iridocorneal angle, resulting in decreased aqueous outflow drainage.
Dimakatso G. Mashala, Bevily Nukeri, Alpheus S. Phaka, Angela N. Mashabu, Mlungisi J. Fakude, Phillip M. Seabi, Matome Mmakgaha, Ramadimetja P. Sedibeng   +7 more
doaj   +1 more source

Effect of phenylephrine on static and dynamic accommodation. [PDF]

, 2019
PURPOSE: We tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics.
Alpern, Antonio J. Del Águila-Carrasco, Atchison, Bernal-Molina, Biggs, Campbell, Charman, Culhane, Del Águila-Carrasco, Esteve-Taboada, Eyeson-Annan, Francisco Lara, Garner, Gimpel, Iván Marín-Franch, José J. Esteve-Taboada, Lara, Liang, Lovasik, López-Alcón, López-Gil, López-Gil, Mordi, Norberto López-Gil, Ostrin, Paula Bernal-Molina, Petersen, Philip B. Kruger, Resurrección Riquelme-Nicolás, Robert Montés-Micó, Roorda, Sarkar, Tarrant, Thibos, Tram, Tucker, Wang, Young, Zetterström, Zetterström   +39 more
core   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

Aging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong, Xiaoyan Han, Siyi Qi, Duo Li, Jingyue Zhang, Linyu Zhang, Shujie Zhang, Qin Jiang, Biao Yan, Chen Zhao   +9 more
wiley   +1 more source

Comparison of 5-year progression of retinitis pigmentosa involving the posterior pole among siblings by means of SD-OCT: a retrospective study [PDF]

, 2018
The blockchain technology promises to transform finance, money and evengovernments. However, analyses of blockchain applicability and robustness typicallyfocus on isolated systems whose actors contribute mainly by running the consensusalgorithm. Here, we
A Hagiwara, A Schatz, AF Wright, AH Hariri, Andi Abeshi, Barbara Sala, BJ Keats, C Bunker, CA Adackapara, CO Pierrottet, CX Cai, DA Bessant, DB Farber, DG Birch, DT Hartong, E Strettoi, E Zrenner, F Testa, Fabio Patelli, GA Fishman, Giovanni Montesano, GM Acland, H Chung, H Hirakawa, H JR, HS Uy, J Sahel, JW Bainbridge, K Holopigian, L Dacruz, L Gränse, Leonardo Colombo, LH Lima, Luca Rossetti, M Haim, Matteo Bertelli, MS Humayun, Paolo Maltese, RP McNabb, S Bundey, S Grover, SG Jacobson, SP Daiger, T Léveillard, T Léveillard, T Sujirakul, V Busskamp, V Kitiratschky, VG Grigoropoulos, W Berger, W Seiple, Y He, Y Makiyama   +52 more
core   +1 more source

Test–retest variability of the full‐field stimulus test in patients with retinitis pigmentosa: REPEAT Study Report No. 4

Acta Ophthalmologica, Volume 104, Issue 1, Page 89-97, February 2026.
Abstract Purpose To evaluate test–retest variability (TRV) of the full‐field stimulus test (FST) in patients with retinitis pigmentosa (RP) and poor best‐corrected visual acuity (BCVA; ≤20/50 Snellen; ≥0.40 logMAR), and to assess the reliability of FST as a clinical endpoint in future RP trials.
J. S. Karuntu, S. B. A. E. Tulp, C. J. F. Boon   +2 more
wiley   +1 more source

Effectiveness of cyclopentolate 1% compared to the combination of cyclopentolate 1%, tropicamide 1%, and phenylephrine 10% in cycloplegic refractive examination

Journal of Clinical Ophthalmology and Research
Context: Refractive errors in children require appropriate eyeglass correction. Cycloplegic refraction is a method used to determine eyeglass prescriptions in children due to their high accommodative power.
Marina Dewi Fitriyani, Sawitri Boengas, Jefman Efendi Marzuki, Saraswati Retno Gumilang   +3 more
doaj   +1 more source

LncRNA DANCR Activates p38/mTOR‐Mediated Autophagy via ANXA2 to Exacerbate Oxygen‐Induced Retinal Neovascularization in Mice

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
This study reveals that the long non‐coding RNA DANCR drives pathological retinal neovascularization in oxygen‐induced retinopathy via an ANXA2‐dependent p38/MAPK/mTOR autophagy pathway. In hypoxic endothelial cells and a murine OIR model, DANCR promotes angiogenesis.
Yini Wang, Jiale Bai, Shihong Zhao
wiley   +1 more source