Results 81 to 90 of about 124,941 (301)

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Genomics-assisted breeding for boosting crop improvement in pigeonpea (Cajanus cajan)

Frontiers in Plant Science, 2015
Pigeonpea is an important pulse crop grown predominantly in the tropical and sub-tropical regions of the world. Although pigeonpea growing area has considerably increased, yield has remained stagnant for the last six decades mainly due to the exposure of
Lekha ePazhamala, Rachit K Saxena, Vikas K Singh, CV eSameerkumar, Vinay eKumar, Pallavi eSinha, Kishan ePatel, Jimmy eObala, Jimmy eObala, Seleman R Kaoneka, Seleman R Kaoneka, P eTongoona, Hussein eShimelis, NVPR eGangarao, Damaris eOdeny, Abhishek eRathore, PS eDharmaraj, KN eYamini, Rajeev K Varshney, Rajeev K Varshney   +19 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Sustainable intensification in coconut for building system resilience and nutritional security of smallholders in Eastern India

npj Sustainable Agriculture
Coconut-based cropping systems are vital to the coastal rural economy, which faces challenges like declining soil fertility, low productivity, pest invasions, and climate change.
Rohan Khopade, Gajanan Sawargaonkar, Santosh Kale, Moses Davala, S. Rakesh, Susree Snigdha Das, RamVikas Verma, Kapil Raje, Ramesh Singh, M. L. Jat   +9 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Root Anatomical Traits and Their Possible Contribution to Drought Tolerance in Grain Legumes

Plant Production Science, 2013
Legumes are mostly grown rainfed and are exposed to various types of drought ranging from terminal drought to intermittent drought. The objective of this study was to compare the root anatomy of six major legume crops in relation to their drought ...
Ramamoorthy Purushothaman, Mainassara Zaman-Allah, Nalini Mallikarjuna, Rajaram Pannirselvam, Lakshmanan Krishnamurthy, Cholenahalli Lakkegowda Laxmipathi Gowda   +5 more
doaj   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

New Capabilities for Observing Precipitation Intensity and Structure Provided by the NASA TROPICS Microwave Radiometer Constellation Mission

The NASA TROPICS (Time-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats) Earth Venture (EVI-3) mission, was successfully launched into orbit on May 8 and May 25, 2023 (two CubeSats in each of the two ...
TROPICS Science Team, William Blackwell
core   +1 more source

Multi‐Scale Bionic Structure Constructs Biomass Flame‐Retardant Thermal Insulation Foam Material

Advanced Science, EarlyView.
Inspired by mussel adhesion and hierarchical brick‐and‐mortar architectures, a cellulose‐based biomimetic foam is constructed by anchoring bentonite nanosheets onto a polydopamine‐decorated cellulose nanofiber network. The resulting foam combines low thermal conductivity with intrinsic flame retardancy and full biodegradability, presenting a ...
Jianming Liao, Lijun Fan, Yunyuan Dong, Xuyu Bao, Xiaobin Chen, Qifu Zheng, Guanqing Zhang, Shen Wang, Wei Chen, Min Zhang, Shuaiming He   +10 more
wiley   +1 more source

Mapping quantitative trait loci controlling high Fe and Zn density in self and open pollinated grains of pearl millet [Pennisetum glaucum (L.) R. Br.]

Frontiers in Plant Science, 2016
Pearl millet is a multipurpose grain/fodder crop of the semi-arid tropics, feeding many of the world’s poorest and most undernourished people. Genetic variation among adapted pearl millet inbreds and hybrids suggests it will be possible to improve grain ...
Sushil Kumar, Charles Tom Hash, Nepolean Thirunavukkarasu, Govind Singh, Vengaldas Rajaram, Abhshek Rathore, Mahesh Damodar Mahendrakar, S Senthilvel, Rattan Yadav, Rakesh Srivastava   +9 more
doaj   +1 more source