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Structural changes and facilitated association of tropoelastin
Archives of Biochemistry and Biophysics, 2003Circular dichroism studies of tropoelastin secondary structure show 4+/-1% alpha-helix in aqueous solutions. This is in contrast to the substantially higher amounts (up to 23+/-7%) of alpha-helix predicted by computer algorithms, which propose that regions of alpha-helix are limited to the alanine-rich cross-linking domains.
Lisa D, Muiznieks +2 more
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Biocompatibility of silk-tropoelastin protein polymers
Biomaterials, 2014Blended polymers are used extensively in many critical medical conditions as components of permanently implanted devices. Hybrid protein polymers containing recombinant human tropoelastin and silk fibroin have favorable characteristics as implantable scaffolds in terms of mechanical and biological properties. A firefly luciferase transgenic mouse model
Hongjuan, Liu +7 more
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Degradation of tropoelastin and skin elastin by neprilysin
Biochimie, 2018Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation. However, information on its elastase activity is still limited. The aim of this study was to investigate the degradation of fibrillar skin elastin by
Angela C. Mora Huertas +6 more
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The Biosynthesis of Tropoelastin in Chick and Pig Tissues
Connective Tissue Research, 1981The cell-free translation of elastin mRNA's from different tissues as well as different animal sources was investigated. In all cases elastin mRNA's coding for both tropoelastin a and b were found. Of special significance was the finding that the ratio of the two tropoelastins varied between lung and aortic tissues and this observation was consistent ...
L L, Barrineau, C B, Rich, J A, Foster
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2012
A serum antibody, specific for tropoelastin was developed in rabbits. The tropoelastin antigen was extracted from the aortas of swine raised on a copper-deficient diet. The amino acid composition and molecular weight of the tropoelastin antigen was determined through amino acid analysis and disc electrophoresis.
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A serum antibody, specific for tropoelastin was developed in rabbits. The tropoelastin antigen was extracted from the aortas of swine raised on a copper-deficient diet. The amino acid composition and molecular weight of the tropoelastin antigen was determined through amino acid analysis and disc electrophoresis.
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Improved methodologies for the isolation and purification of tropoelastin
Analytical Biochemistry, 1980Abstract Increased yields of purified tropoelastin were obtained from lathyritic chicks which had been raised on normal commercial starting feed for 1 week followed by 8 days on commercial starting feed supplemented with 0.1% aminoacetonitrile·HCl and 0.05% ϵ-aminocaproic acid.
J A, Foster +4 more
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Intrinsic enzyme activity associated with tropoelastin
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976The presence of an enzyme(s) associated with purified tropoelastin has been established. Results indicate that the enzyme(s) remains closely associated with the soluble elastin throughout the entire purification procedure suggesting that it is very tightly bound. Enzymatic activity is optimum through the pH range 7-9 (37 degrees C) and can be inhibited
R P, Mecham, J A, Foster, C, Franzblau
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Tropoelastin — A multifaceted naturally smart material
Advanced Drug Delivery Reviews, 2013Tropoelastin dominates the physical performance of human elastic tissue as it is assembled to make elastin. Tropoelastin is increasingly appreciated as a protein monomer with a defined solution shape comprising modular, bridged regions that specialize in elasticity and cell attachment, which collectively participate in macromolecular assembly.
Suzanne M, Mithieux +2 more
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Synthesis of a cross‐linked polypentapeptide of tropoelastin
Biopolymers, 1976AbstractThe synthesis of a cross‐linked polypentapeptide (an insoluble product) by means of a cross‐linking reaction between a lysine‐containing (1%) polypentapeptide and a glutamic acid‐containing (2%) polypentapeptide is described, following description of the synthesis and polymerization of the corresponding pentapeptide p‐nitrophenyl esters.
K, Okamoto, D W, Urry
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Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2004
The vertebrate cornea is an avascular tissue and does not contain elastic fibers. We tested the capacity of corneal epithelial cells and stromal keratocytes to synthesize tropoelastin. Explant cultures and cell cultures were obtained from these two cell types in standard culture conditions.
N, Isnard +3 more
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The vertebrate cornea is an avascular tissue and does not contain elastic fibers. We tested the capacity of corneal epithelial cells and stromal keratocytes to synthesize tropoelastin. Explant cultures and cell cultures were obtained from these two cell types in standard culture conditions.
N, Isnard +3 more
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