Arterial stiffening in western diet-fed mice is associated with increased vascular elastin, transforming growth factor-ß, and plasma neuraminidase [PDF]
, 2016 Consumption of excess fat and carbohydrate (Western diet, WD) is associated with alterations in the structural characteristics of blood vessels. This vascular remodeling contributes to the development of cardiovascular disease, particularly as it affects
Alvira +66 more
core +1 more source
Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin
The FASEB Journal, 2019 Lysyl oxidases (LOXs) play a central role in extracellular matrix remodeling during development and tumor growth and fibrosis through cross‐linking of collagens and elastin.
C. Schmelzer +15 more
semanticscholar +1 more source
Structural studies of elastic fibre and microfibrillar proteins
Matrix Biology Plus, 2021 Elastic tissues owe their functional properties to the composition of their extracellular matrices, particularly the range of extracellular, multidomain extensible elastic fibre and microfibrillar proteins.
Mukti Singh +3 more
doaj +1 more source
Extracellular Matrix Molecules Facilitating Vascular Biointegration
Journal of Functional Biomaterials, 2012 All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Martin K.C. Ng +3 more
doaj +1 more source
Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. [PDF]
PLoS ONE, 2013 Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower ...
Mari Ekman +5 more
doaj +1 more source
Biocatalytic Synthesis of Polymers of Precisely Defined Structures [PDF]
, 1999 The fabrication of functional nanoscale devices requires the construction of complex architectures at length scales characteristic of atoms and molecules. Currently microlithography and micro-machining of macroscopic objects are the preferred methods for
AB Mauger +59 more
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Cultured Human Keratinocytes Express Tropoelastin
Journal of Investigative Dermatology, 1997 We detected elastin mRNA in cultured normal human keratinocytes by RNase protection assay. The content of elastin mRNA was estimated at approximately one-twentieth of that of cultured skin fibroblasts. Tropoelastin polypeptide with a molecular weight of 68 kDa was detected in the preparation of culture medium of normal human keratinocytes by western ...
Kajiya, Hiroyoshi +5 more
openaire +2 more sources
Tropoelastin: A versatile, bioactive assembly module [PDF]
Acta Biomaterialia, 2014 Elastin provides structural integrity, biological cues and persistent elasticity to a range of important tissues, including the vasculature and lungs. Its critical importance to normal physiology makes it a desirable component of biomaterials that seek to repair or replace these tissues.
Steven G, Wise +6 more
openaire +2 more sources
Influence of the architecture on the molecular mobility of synthetic fragments inspired from human tropoelastin [PDF]
, 2015 This work deals with the vibrational, thermal and dielectric characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin. This peptide was shown to form amyloid-like fibers implied in neurodegenerative pathologies.
Bochicchio, Brigida +5 more
core +2 more sources
Elastin haploinsufficiency induces alternative aging processes in the aorta [PDF]
, 2008 Elastin, the main component of elastic fibers, is synthesized only in early life and provides the blood vessels with their elastic properties. With aging, elastin is progressively degraded, leading to arterial enlargement, stiffening, and dysfunction ...
Boyle, Walter A +13 more
core +3 more sources