Results 91 to 100 of about 2,582,733 (281)

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

BRET biosensor analysis of receptor tyrosine kinase functionality

Frontiers in Endocrinology, 2013
Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui, Wei-na eCong, Caitlin M Daimon, Bronwen eMartin, Stuart eMaudsley   +4 more
doaj   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton, on behalf of the WOREO Knee Study Group   +14 more
wiley   +1 more source

Follicle-stimulating hormone receptor: Advances and remaining challenges [PDF]

In: Arun K. Shukla (ed.), dir., G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A (p. 1-58). International Review of Cell and Molecular Biology, 338 (1\`ere ed.). USA : Elsevier. 171 p. (2018), 2018
Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the gonads. The FSH/FSHR system presents many peculiarities compared to classical G protein-coupled receptors (GPCRs).
arxiv   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques

Molecules, 2018
The aim of this study was to identify new potentially active compounds for three protein targets, tropomyosin receptor kinase A (TrkA), N-methyl-d-aspartate (NMDA) receptor, and leucine-rich repeat kinase 2 (LRRK2), that are related to various ...
Larisa Ivanova, Mati Karelson, Dimitar A. Dobchev   +2 more
doaj   +1 more source

γ-Enolase enhances Trk endosomal trafficking and promotes neurite outgrowth in differentiated SH-SY5Y cells

Cell Communication and Signaling, 2021
Background Neurotrophins can activate multiple signalling pathways in neuronal cells through binding to their cognate receptors, leading to neurotrophic processes such as cell survival and differentiation.
Anja Pišlar, Janko Kos
doaj   +1 more source

A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]

arXiv, 2020
Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv  

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis [PDF]

Annals of the Rheumatic Diseases, 2016
Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined the effects of a TrkA inhibitor (AR786) on pain behaviour, synovitis and joint pathology in two rat OA models.Knee OA ...
Nwosu, Lilian Ngozi, Mapp, Paul I., Chapman, Victoria, Walsh, David A.   +3 more
openaire   +5 more sources