Results 101 to 110 of about 2,582,733 (281)

A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension

Cytoskeleton, EarlyView.
Abstract Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and ...
Wan J. Gan, Rabina Giri, Jakob Begun, Helen E. Abud, Edna C. Hardeman, Peter W. Gunning, Alpha S. Yap, Ivar Noordstra   +7 more
wiley   +1 more source

The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases

Life, 2021
Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the central nervous system. Numerous studies suggest that BDNF has extensive roles by binding to its specific receptor, tropomyosin-related kinase receptor B (TrkB ...
Peng-Zhou Hang, Hua Zhu, Pei-Feng Li, Jie Liu, Feng-Qin Ge, Jing Zhao, Zhi-Min Du   +6 more
doaj   +1 more source

Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic

ESC Heart Failure, EarlyView.
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit   +12 more
wiley   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer [PDF]

, 2009
Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, RET and neurotrophic tyrosine kinase receptor type I (NTRK1)
Baumgartner, Adolf, Kwan, Johnson, Lu, Chun-Mei, Wang, Mei, Weier, Heinz-Ulrich G., Weier, Jingly F., Zitzelsberger, Horst F.   +6 more
core   +2 more sources

BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors

npj Precision Oncology
Aberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng, Hong Chen, Bang Fu, Hongming Pan, Jiabing Wang, Weidong Han   +5 more
doaj   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model [PDF]

Maqboul A, Elsadek B. (2018) Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model. PeerJ 6:e4622 https://doi.org/10.7717/peerj.4622, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient receptor potential vanilloid 1 (TRPV1) and of transient receptor potential vanilloid 4 ...
arxiv   +1 more source

Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides

Interdisciplinary Medicine, EarlyView.
Bacterial extracellular vesicles (BEVs) are increasingly exploited as therapeutic agents or delivery vehicles for disease treatment due to their intrinsic structure, delivery capacity, immunogenic property, facile production, and versatile modification.
Yejiao Shi, Zelin Zheng, Wen Wang, Honggang Hu   +3 more
wiley   +1 more source

Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth? [PDF]

, 2018
Obesity is one of the major epidemics of this millennium, and its incidence is growing worldwide. Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become a disease of increasing prevalence and a leading cause of morbidity ...
El Hadi, Hamza, Rossato, Marco, Vettor, Roberto   +2 more
core   +2 more sources

Comparative effectiveness of larotrectinib and entrectinib for TRK fusion cancer. [PDF]

, 2022
Larotrectinib and entrectinib are tumor-agnostic tropomyosin receptor kinase (TRK) inhibitors that are indicated for the treatment of advanced or metastatic solid tumor cancers with neurotrophic tyrosine receptor kinase (NTRK) gene fusions.
Brose, Marcia S, Carlson, Josh J, Federman, Noah, Italiano, Antoine, Kummar, Shivaani, Lassen, Ulrik, Sullivan, Sean D   +6 more
core   +1 more source