Results 101 to 110 of about 2,662,368 (270)
Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques
Molecules, 2018 The aim of this study was to identify new potentially active compounds for three protein targets, tropomyosin receptor kinase A (TrkA), N-methyl-d-aspartate (NMDA) receptor, and leucine-rich repeat kinase 2 (LRRK2), that are related to various ...
Larisa Ivanova +2 more
doaj +1 more source
A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]
arXiv, 2020 Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv
Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides
Interdisciplinary Medicine, EarlyView.Bacterial extracellular vesicles (BEVs) are increasingly exploited as therapeutic agents or delivery vehicles for disease treatment due to their intrinsic structure, delivery capacity, immunogenic property, facile production, and versatile modification.
Yejiao Shi +3 more
wiley +1 more source
A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury
Neuroprotection, EarlyView.This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley +1 more source
BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors
npj Precision OncologyAberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng +5 more
doaj +1 more source
Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model [PDF]
Maqboul A, Elsadek B. (2018) Expression profiles of TRPV1, TRPV4,
TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced
neuropathy rat model. PeerJ 6:e4622 https://doi.org/10.7717/peerj.4622, 2018 Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient receptor potential vanilloid 1 (TRPV1) and of transient receptor potential vanilloid 4 ...
arxiv +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Repotrectinib is approved in the US for treating ROS1‐positive non‐small cell lung cancer (NSCLC) and solid tumors harboring an NTRK gene fusion. A Population Pharmacokinetic (PopPK) model for repotrectinib was developed using data from 620 adults (118 healthy volunteers and 502 patients) across seven studies and 24 pediatric patients from one
Shengnan Du +8 more
wiley +1 more source
Neurobiology of Disease, 2018 Post-traumatic epilepsy is one of the most common and difficult to treat forms of acquired epilepsy worldwide. Currently, there is no effective way to prevent post-traumatic epileptogenesis.
Feng Gu +4 more
doaj
Cell Communication and Signaling, 2021 Background Neurotrophins can activate multiple signalling pathways in neuronal cells through binding to their cognate receptors, leading to neurotrophic processes such as cell survival and differentiation.
Anja Pišlar, Janko Kos
doaj +1 more source
PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development
Cells, 2021 During the development of the nervous system, synaptogenesis occurs in excess though only the appropriate connections consolidate. At the neuromuscular junction, competition between several motor nerve terminals results in the maturation of a single axon
Neus Garcia +7 more
doaj +1 more source