Results 111 to 120 of about 2,662,368 (270)
Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications
Small, EarlyView.Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin +2 more
wiley +1 more source
A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells [PDF]
, 2004 We have investigated transforming growth factor beta (TGF-beta)-mediated induction of actin stress fibers in normal and metastatic epithelial cells. We found that stress fiber formation requires de novo protein synthesis, p38Mapk and Smad signaling.
Bakin, A. V. +5 more
core +2 more sources
Current Problems in Cancer: Case Reports, 2022 Here, we describe a patient with advanced metastatic non-small cell lung cancer (NSCLC) who harbors a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, identified by liquid biopsy, and has a known history of heart disease.
Derrick W. Su +5 more
doaj
Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization [PDF]
, 2018 Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial. Here we consider a lattice model yielding a phase diagram that includes several states proposed to be relevant for the cell membrane ...
arxiv +1 more source
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
British Journal of Pharmacology, EarlyView.Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang +5 more
wiley +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
Dynamic Studies of Scaffold-dependent Mating Pathway in Yeast [PDF]
, 2006 The mating pathway in \emph{Saccharomyces cerevisiae} is one of the best understood signal transduction pathways in eukaryotes. It transmits the mating signal from plasma membrane into the nucleus through the G-protein coupled receptor and the mitogen-activated protein kinase (MAPK) cascade. According to the current understandings of the mating pathway,
arxiv +1 more source
Role of the RAB27/SYTL Axis in Tumor Microenvironment Construction
Cancer Science, EarlyView.This review focuses on the role of the RAB27/SYTL axis in various cancer types associated with tumor microenvironment modifications. The importance of this pathway and the potential therapeutic strategies targeting vesicle production for the treatment of cancer are also discussed.
Miwa Tanaka, Takuro Nakamura
wiley +1 more source
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease [PDF]
, 2010 Because regional blood flow increases in association with the increased metabolic demand generated by localised increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in ...
Attwell, D., Hall, C.N., Hamilton, N.B.
core +3 more sources
Relationship between cellular response and behavioral variability in bacterial chemotaxis [PDF]
, 2007 Bacterial chemotaxis in Escherichia coli is a canonical system for the study of signal transduction. A remarkable feature of this system is the coexistence of precise adaptation in population with large fluctuating cellular behavior in single cells (Korobkova et al. 2004, Nature, 428, 574).
arxiv +1 more source