Early Origins of Asthma and Allergies: Clues From Studies in China
Clinical &Experimental Allergy, EarlyView.The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang +5 more
wiley +1 more source
Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain [PDF]
, 2010 Pain often accompanies cancer and most current therapies for treating cancer pain have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomyosin receptor kinase A (TrkA) has become an attractive target for
Bloom, Aaron P +6 more
core +3 more sources
Journal of Chest Surgery, 2021 Resection and reconstruction of the chest wall for the radical surgical treatment of malignant soft tissue tumors are currently considered a substantial challenge for thoracic surgeons.
Wildor Samir Cubas Llalle +3 more
doaj +1 more source
Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk
Cell Proliferation, EarlyView.This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour +3 more
wiley +1 more source
Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling [PDF]
, 2014 International audienceIntroduction: Giant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischaemic manifestations that involve large vessels.
Alexis Régent +15 more
core +2 more sources
Toward molecular phenotyping of temporal lobe epilepsy by spatial omics
Epilepsia, EarlyView.Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen +33 more
wiley +1 more source
Phenyl Saligenin Phosphate Induced Caspase-3 and c-Jun N-Terminal Kinase Activation in Cardiomyocyte-Like Cells [PDF]
, 2015 At present, little is known about the effect(s) of organophosphorous compounds (OPs) on cardiomyocytes. In this study we have investigated the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos)
A. Christopher Garner +11 more
core +2 more sources
Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network [PDF]
, 2010 Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of proteins within the cell.
arxiv +1 more source
Journal of Diabetes Investigation, EarlyView.Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang +5 more
wiley +1 more source
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain [PDF]
, 2016 The neurotrophin family of growth factors, comprised of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is implicated in the physiology of chronic pain.
Angus Nedderman +17 more
core +3 more sources