Results 131 to 140 of about 2,662,368 (270)

A Case Report of Lung Adenocarcinoma with EGFR G719A Mutation 
and LMNA-NTRK1 Fusion

Chinese Journal of Lung Cancer
Fusion variations of neurotrophic receptor tyrosine kinase (NTRK) are oncogenic drivers in various solid tumors such as breast cancer, salivary gland carcinoma, infant fibrosarcoma, etc.
Shiqi SONG, Yaxian YANG, Weiquan LUO, Yueya LIANG, Qi LI, Tongxu ZHUO, Weibin XIONG, Jian HUANG   +7 more
doaj   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

Global proteomics analysis of the response to starvation in C. elegans [PDF]

, 2015
Periodic starvation of animals induces large shifts in metabolism but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions.
Alejandro Brenes Murillo, Angelo, Angus I. Lamond, Anton Gartner, Baugh, Bin Wang, Chang, Cox, Cui, Dong, Ehsan Pourkarimi, Felix, Fredens, Grun, Handke, Henderson, Hsin, Huang, Kaeberlein, Kenyon, Larance, Larance, Larance, Liang, Long, Ly, Mark Larance, McBryant, Murphy, Narbonne, Ong, Ooi, Pourkarimi, Raharjo, Rechavi, Ritorto, Robert Kent, Sabidó, Seidel, Sheaffer, Shen, Supek, Uno, Updike, Van Gilst, Van Gilst, Vellai, Wessel, Whittle, Yankovskaya, You, Yuan, Zhao   +52 more
core   +2 more sources

The central benefit of physiologically induced ketogenic states

The Journal of Physiology, EarlyView.
Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco, Giuseppe Petito, Rosalba Senese, Maria Moreno, Assunta Lombardi, Antonia Lanni, Pieter de Lange   +6 more
wiley   +1 more source

A Monte Carlo study of ligand-dependent integrin signal initiation [PDF]

arXiv, 2010
Integrins are allosteric cell adhesion receptors that control many important processes, including cell migration, proliferation, and apoptosis. Ligand binding activates integrins by stabilizing an integrin conformation with separated cytoplasmic tails, thus enabling the binding of proteins that mediate cytoplasmic signaling.
arxiv  

Metastatic melanoma-A review of current and future perspective [PDF]

arXiv, 2020
Metastatic Melanoma, the fifth most common cancer in the western countries and the most common malignancy diagnosed in United States present itself as the most lethal treatment resistant cancer worldwide. In addition to the reactive oxygen species(ROS), mutations in the genes encoding receptors and non-receptor tyrosine/serene/threonine protein kinases
arxiv  

Early sensorimotor restriction in rats induces age‐dependent mitochondrial alterations in skeletal muscles and brain structures

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever, Olivier Dupuy, Erwan Dupont, Marie‐Hélène Canu, Frederic Daussin   +4 more
wiley   +1 more source

Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine

Frontiers in Medicine, 2019
Non-small-cell lung cancers (NSCLC) represent 85% of all lung cancers, with adenocarcinoma as the most common subtype. Since the 2000's, the discovery of molecular alterations including epidermal growth factor receptor (EGFR) mutations and anaplastic ...
Julian Pinsolle, Julian Pinsolle, Anne McLeer-Florin, Anne McLeer-Florin, Anne McLeer-Florin, Matteo Giaj Levra, Matteo Giaj Levra, Florence de Fraipont, Florence de Fraipont, Camille Emprou, Camille Emprou, Elisa Gobbini, Elisa Gobbini, Anne-Claire Toffart, Anne-Claire Toffart, Anne-Claire Toffart   +15 more
doaj   +1 more source

Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer

Expert Review of Clinical Pharmacology, 2019
Introduction: Detecting oncogenic drivers across multiple cancers has brought about a shift toward a more targeted therapeutic approach. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are genomic rearrangements containing the kinase domain of ...
N. Federman, R. McDermott
semanticscholar   +1 more source

The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view

The Journal of Physiology, EarlyView.
Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland, Paul J. LeBlanc, Paula Duarte‐Guterman, Val A. Fajardo, Rebecca E. K. MacPherson   +4 more
wiley   +1 more source