Results 131 to 140 of about 2,582,733 (281)
A Case Report of Lung Adenocarcinoma with EGFR G719A Mutation and LMNA-NTRK1 Fusion
Chinese Journal of Lung CancerFusion variations of neurotrophic receptor tyrosine kinase (NTRK) are oncogenic drivers in various solid tumors such as breast cancer, salivary gland carcinoma, infant fibrosarcoma, etc.
Shiqi SONG +7 more
doaj +1 more source
Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, EarlyView.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source
A Monte Carlo study of ligand-dependent integrin signal initiation [PDF]
arXiv, 2010 Integrins are allosteric cell adhesion receptors that control many important processes, including cell migration, proliferation, and apoptosis. Ligand binding activates integrins by stabilizing an integrin conformation with separated cytoplasmic tails, thus enabling the binding of proteins that mediate cytoplasmic signaling.
arxiv
Metastatic melanoma-A review of current and future perspective [PDF]
arXiv, 2020 Metastatic Melanoma, the fifth most common cancer in the western countries and the most common malignancy diagnosed in United States present itself as the most lethal treatment resistant cancer worldwide. In addition to the reactive oxygen species(ROS), mutations in the genes encoding receptors and non-receptor tyrosine/serene/threonine protein kinases
arxiv
The central benefit of physiologically induced ketogenic states
The Journal of Physiology, EarlyView.Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco +6 more
wiley +1 more source
Frontiers in Medicine, 2019 Non-small-cell lung cancers (NSCLC) represent 85% of all lung cancers, with adenocarcinoma as the most common subtype. Since the 2000's, the discovery of molecular alterations including epidermal growth factor receptor (EGFR) mutations and anaplastic ...
Julian Pinsolle +15 more
doaj +1 more source
MO01.35 Efficacy and Safety of Larotrectinib in Patients with Tropomyosin Receptor Kinase (TRK) Fusion Lung Cancer [PDF]
, 2021 Alexander Drilon +12 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever +4 more
wiley +1 more source
Phenyl Saligenin Phosphate Induced Caspase-3 and c-Jun N-Terminal Kinase Activation in Cardiomyocyte-Like Cells [PDF]
, 2015 At present, little is known about the effect(s) of organophosphorous compounds (OPs) on cardiomyocytes. In this study we have investigated the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos)
A. Christopher Garner +11 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Polyspike epileptiform discharges and excitatory unit spike activities are observed in rats with kainic acid (KA)‐induced hippocampal seizures. A weak electric field generated by cathodal direct current stimulation (ctDCS) at CA1 reduces seizure excitability by decreasing the frequency and amplitude of epileptic spikes and ...
Chia‐Chu Chiang +7 more
wiley +1 more source