Results 141 to 150 of about 74,566 (254)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

NTRK-rearranged spindle cell tumor with SPECC1L-NTRK3 fusion in the thoracic spine: a case report

Journal of Cancer Research and Clinical Oncology
Neurotrophic Tyrosine Receptor Kinase (NTRK)-rearranged spindle cell tumors are a category of soft tissue tumors characterized by rearrangements of the NTRK gene family (NTRK1, NTRK2, and NTRK3), which leads to distinct molecular genetics, morphological,
Mi Zhou, Huaiyuan Xu, Jianxiong Niu, Qibing Yang, Anqi Wang, Hao Wu, Xiangqin Wang, Meng Yang, Jinxin Hu, Qinglian Tang, Jin Wang   +10 more
doaj   +1 more source

Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model [PDF]

, 2014
Metastatic bone cancer causes severe pain, but current treatments often provide insufficient pain relief. One of the reasons is that mechanisms underlying bone cancer pain are not solved completely.
Ichikawa, Hiroyuki, Itano, Yoshitaro, Kaku, Ryuji, Kanzaki, Hirotaka, Matsuoka, Yoshikazu, Mizobuchi, Satoshi, Morimatsu, Hiroshi, Muto, Noriko, Obata, Norihiko, Omiya, Hiroki, Sato, Tadasu, Taniguchi, Arata, Tomotsuka, Naoto   +12 more
core   +2 more sources

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

A rich network of S100+/tropomyosin receptor kinase A+ nerve fibers in the connective tissue wall of radicular cysts: An immunohistochemical study of biopsy cases

Saudi Endodontic Journal
Introduction: Limited information is available regarding the presence of nerve fibres in human radicular granulomas and cysts. The aim of the present study was to map the neural network of human radicular cysts by the immunohistochemical expression of ...
Nikolaos P. Kerezoudis, Taxiarchis G. Kontogiannis, Konstantinos I. Tosios   +2 more
doaj   +1 more source

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

PLoS Biology, 2018
The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3.
Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasure   +10 more
doaj   +1 more source

Immune checkpoint inhibitor treatment in patients with oncogene-addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion

ESMO Open, 2019
The introduction of targeted treatments and more recently immune checkpoint inhibitors (ICI) to the treatment of metastatic non-small cell lung cancer (NSCLC) has dramatically changed the prognosis of selected patients.
Nicola Normanno, Matthias Preusser, Julien Mazières, Anna S. Berghoff, Beatriz Bellosillo, Christophe Caux, Adrianus de Langen, Mariano Provencio, Federico Rojo, Jurgen Wolf   +9 more
doaj   +1 more source

ProteinDJ: A high‐performance and modular protein design pipeline

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Leveraging artificial intelligence and deep learning to generate proteins de novo (a.k.a. ‘synthetic proteins’) has unlocked new frontiers of protein design. Deep learning models trained on protein structures can generate novel protein designs that explore structural landscapes unseen by evolution.
Dylan Silke, Julie Iskander, Junqi Pan, Andrew P. Thompson, Anthony T. Papenfuss, Isabelle S. Lucet, Joshua M. Hardy   +6 more
wiley   +1 more source

Novel therapeutic strategies for rare mutations in non-small cell lung cancer

Scientific Reports
Lung cancer is still the leading cause of cancer-related mortality. Over the past two decades, the management of non-small cell lung cancer (NSCLC) has undergone a significant revolution.
Qitao Gou, Qiheng Gou, Xiaochuan Gan, Yuxin Xie   +3 more
doaj   +1 more source