The Journal of Physiology, EarlyView.Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland +4 more
wiley +1 more source
464P Intra-patient (Pt) comparison from larotrectinib (Laro) clinical trials in tropomyosin receptor kinase (TRK) fusion cancer: An expanded dataset [PDF]
, 2022 A. Italiano +19 more
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The Journal of Physiology, EarlyView.Abstract figure legend Exercise‐induced increases in forearm venous plasma and serum brain‐derived neurotrophic factor (BDNF) are often assumed to be indicative of release from the brain. Sixteen healthy and physically fit adults (20–40 years old) were recruited to investigate whether exercise‐induced changes in forearm venous mature BDNF (mBDNF) and ...
Olga Tarassova +10 more
wiley +1 more source
Role of caldesmon in the regulation of smooth muscle contraction [PDF]
, 1986 Bibliography: p.
Ngai, Philip Kam-Ming
core +2 more sources
Research Progress of Tropomyosin Receptor Kinase (TRK) Inhibitors [PDF]
, 2022 Junzhe Yang +4 more
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Equilibrium Blocking Model of Isometric Tension [PDF]
arXiv, 2009 Calcium activation of striated muscle is known to exhibit a strongly cooperative dependency on calcium. Because the calcium receptor protein, troponin (Tn) is known to bind calcium non-cooperatively and has yet to be linked to a cooperative change in the myosin-blocking protein, tropomyosin (Tm), we describe a model in which cooperativity is ...
arxiv
Cardiac Troponin I Biosensors: Innovations in Real‐Time Diagnosis of Cardiovascular Diseases
Analytical Science Advances, Volume 6, Issue 1, June 2025.ABSTRACT Cardiac troponin I (cTnI) is a crucial biological macromolecule found in the contractile apparatus of cardiac myocytes, exclusively expressed in cardiomyocytes. It is released into the bloodstream upon cardiac tissue injury, serving as a vital biomarker for the early detection of various heart diseases. Despite advancements in cTnI diagnostics
Sara Ebrahimi +7 more
wiley +1 more source
Marine Drugs, 2018 Perfluorooctane sulfonate (PFOS), a stable fluorosurfactant, causes endoplasmic reticulum (ER) stress in the brain. This study was designed to investigate whether a phycoerythrin-derived peptide of Pyropia yezoensis (PYP) reduces PFOS-induced ER stress ...
Jeong Hwan Oh +2 more
doaj +1 more source
Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology [PDF]
, 2020 Yoichi Naito +25 more
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JOR SPINE, Volume 8, Issue 2, June 2025.Within this manuscript, bioinformatics and experimental methods are used to explore the role of circadian rhythm and immunity in Intervertebral Disc Degeneration (IVDD). CCND1, FOXO1, FRMD8, NTRK2, PRRT1, and TFPI were successfully demonstrated to be hub rhythm‐related genes in the process of IVDD together with immunity.
Yongbo Zhang +5 more
wiley +1 more source