Tropomyosin receptor kinase a - Open Access .click

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Breakthroughs and challenges in the management of tropomyosin receptor kinase fusion-positive tumors. [PDF]

Ann Transl Med, 2019
The past decade has witnessed a paradigm shift in the treatment of cancer, moving from ‘one size fits all’ to a more precision medicine-based approach owing to the development of molecular diagnostic technologies capable of identifying an increasing number of actionable genomic alterations in the tumor tissue and circulating tumor DNA.
Mamdani H, Jalal SI.
europepmc +4 more sources

A tropomyosin-receptor kinase-fused gene mutation associates with vacuolar myopathy. [PDF]

Neurol Genet, 2018
A 44-year-old Caucasian man presented with a 7-year history of upper and lower limb muscle fasciculations and cramps, progressive asymmetric weakness, muscle atrophy, and length-dependent sensory loss. His parents (deceased), 3 older siblings, and 3 children had no history of neurologic symptoms, including weakness and sensory symptoms, with the ...
Madigan NN +6 more
europepmc +5 more sources

Survival Outcomes of Patients With Tropomyosin Receptor Kinase Fusion-Positive Cancer Receiving Larotrectinib Versus Standard of Care: A Matching-Adjusted Indirect Comparison Using Real-World Data. [PDF]

JCO Precis Oncol, 2023
Bokemeyer C +7 more
europepmc +3 more sources

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia [PDF]

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi +6 more
doaj +2 more sources

The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia. [PDF]