Results 31 to 40 of about 74,566 (254)

Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer [PDF]

Expert Review of Clinical Pharmacology, 2019
Introduction: Detecting oncogenic drivers across multiple cancers has brought about a shift toward a more targeted therapeutic approach. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are genomic rearrangements containing the kinase domain of ...
N. Federman, R. McDermott
semanticscholar   +3 more sources

Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid, which plays a crucial role in the regulation of cell proliferation, migration, and differentiation. LPA exerts its biological effects mainly through binding to cell-surface LPA receptors (LPA1-6), which belong to the G protein-coupled receptor (GPCR) family.
L. Nan, Jianxin Wei, Anastasia M Jacko, M. Culley, Jing Zhao, V. Natarajan, Haichun Ma, Yutong Zhao   +7 more
semanticscholar   +3 more sources

Messenger RNA expression patterns of p75 neurotrophin receptor and tropomyosin-receptor-kinase A following spinal cord injury [PDF]

The Journal of Spinal Cord Medicine, 2013
Induction of p75 neurotrophin receptor (p75NTR) could be one of the first steps that initiate apoptotic cascade after injury, or it may indicate regeneration responses undertaken by the injured system, possibly in collaboration with resident tropomyosin-receptor-kinase (Trk).To measure quantitative changes in messenger RNA (mRNA) expression levels of ...
Fatemeh Montazeri, A. Esmaeili, M. Miroliaei, S. Moshtaghian   +3 more
semanticscholar   +3 more sources

Influenza A virus activates cellular Tropomyosin receptor kinase A (TrkA) signaling to promote viral replication and lung inflammation. [PDF]

PLoS Pathog, 2022
Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory responses.
Verma V, Dileepan M, Huang Q, Phan T, Hu WS, Ly H, Liang Y.   +6 more
europepmc   +4 more sources

Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer

Case Reports in Oncology, 2023
In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these ...
Lorenz Frehner, Simon Haefliger, Ferdinando Cerciello, Tobias Grob, Sabine Schmid   +4 more
doaj   +1 more source

A tropomyosin-receptor kinase-fused gene mutation associates with vacuolar myopathy [PDF]

Neurology Genetics, 2018
A 44-year-old Caucasian man presented with a 7-year history of upper and lower limb muscle fasciculations and cramps, progressive asymmetric weakness, muscle atrophy, and length-dependent sensory loss. His parents (deceased), 3 older siblings, and 3 children had no history of neurologic symptoms, including weakness and sensory symptoms, with the ...
Madigan, Nicolas N., Tracy, Jennifer A., Litchy, William J., Niu, Zhiyv, Chen, Chunhua, Ling, Kun, Milone, Margherita   +6 more
openaire   +2 more sources

Sedentary Conditions Promote Subregionally Specific Changes in Brain-Derived Neurotrophic Factor in the Rostral Ventrolateral Medulla

Frontiers in Physiology, 2021
A sedentary lifestyle is the top preventable cause of death and accounts for substantial socioeconomic costs to society. The rostral ventrolateral medulla regulates blood pressure under normal and pathophysiological states, and demonstrates inactivity ...
Bozena E. Fyk-Kolodziej, Patrick J. Mueller   +1 more
doaj   +1 more source

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]

, 2016
BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I, Ellinwood, N Matthew, Esko, Jeffrey D, Gordts, Philip L, Khalid, Omar, Schwartz, Philip H, Vera, Moin U, Wang, Raymond Y   +7 more
core   +8 more sources

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network. [PDF]

Ann Oncol, 2020
Demetri GD, Antonescu CR, Bjerkehagen B, Bovée JVMG, Boye K, Chacón M, Dei Tos AP, Desai J, Fletcher JA, Gelderblom H, George S, Gronchi A, Haas RL, Hindi N, Hohenberger P, Joensuu H, Jones RL, Judson I, Kang YK, Kawai A, Lazar AJ, Le Cesne A, Maestro R, Maki RG, Martín J, Patel S, Penault-Llorca F, Premanand Raut C, Rutkowski P, Safwat A, Sbaraglia M, Schaefer IM, Shen L, Serrano C, Schöffski P, Stacchiotti S, Sundby Hall K, Tap WD, Thomas DM, Trent J, Valverde C, van der Graaf WTA, von Mehren M, Wagner A, Wardelmann E, Naito Y, Zalcberg J, Blay JY.   +47 more
europepmc   +2 more sources

Brain‐Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Brain‐derived neurotrophic factor (BDNF) is expressed in neuronal and nonneuronal cells and may affect vascular functions via its receptor, tropomyosin‐related kinase B (TrkB).
Sarah Zierold, Katja Buschmann, Sogol Gachkar, Magdalena L. Bochenek, David Velmeden, Lukas Hobohm, Christian‐Friedrich Vahl, Katrin Schäfer   +7 more
doaj   +1 more source