Results 41 to 50 of about 74,566 (254)

Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin [PDF]

open access: yesJournal of Integrative Neuroscience, 2019
Hippocampal neurogenesis plays an important role in the onset and treatment of depressive disorders. Previous studies suggest that paeoniflorin could be used as an antidepressant for treating rats subjected to chronic unpredictable stress. In this study,
Li-Bing Chen, Feng-Mei Qiu, Xiao-Ming Zhong, Cheng Hong, Zhen Huang
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

open access: yes, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R   +8 more
core   +2 more sources

Caldesmon regulates actin dynamics to influence cranial neural crest migration in Xenopus [PDF]

open access: yes, 2011
Caldesmon (CaD) is an important actin modulator that associates with actin filaments to regulate cell morphology and motility. Although extensively studied in cultured cells, there is little functional information regarding the role of CaD in migrating ...
Bronner-Fraser, Marianne   +2 more
core   +2 more sources

Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts

open access: yesScientific Reports, 2021
Constructive remodeling of focal esophageal defects with biodegradable acellular grafts relies on the ability of host progenitor cell populations to repopulate implant regions and facilitate growth of de novo functional tissue.
Gokhan Gundogdu   +10 more
doaj   +1 more source

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons

open access: yesNeurobiology of Disease, 2018
Post-traumatic epilepsy is one of the most common and difficult to treat forms of acquired epilepsy worldwide. Currently, there is no effective way to prevent post-traumatic epileptogenesis.
Feng Gu   +4 more
doaj   +1 more source

Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur

open access: yesMolecular Pain, 2017
Sequestration of nerve growth factor (NGF) significantly attenuates skeletal pain in both animals and humans. However, relatively little is known about the specific cell types that express NGF or its cognate receptors tropomyosin receptor kinase A (TrkA)
Stephane R. Chartier   +3 more
semanticscholar   +1 more source

Small Interfering RNA Targeting Nerve Growth Factor Alleviates Allergic Airway Hyperresponsiveness

open access: yesMolecular Therapy: Nucleic Acids, 2014
Airway hyperresponsiveness is the hallmark of allergic asthma and caused by multiple factors. Nerve growth factor (NGF), a neurotrophin, is originally known for regulation of neural circuit development and function.
Yi-Lien Chen   +3 more
doaj   +1 more source

Larotrectinib in TRK fusion-positive, metastatic non-small cell lung cancer (NSCLC) after treatment with entrectinib in a patient with a history of coronary artery disease

open access: yesCurrent Problems in Cancer: Case Reports, 2022
Here, we describe a patient with advanced metastatic non-small cell lung cancer (NSCLC) who harbors a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, identified by liquid biopsy, and has a known history of heart disease.
Derrick W. Su   +5 more
doaj   +1 more source

Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]

open access: yes, 2019
Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela   +14 more
core   +2 more sources

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

open access: yes, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

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