Results 41 to 50 of about 2,582,733 (281)

Tropomyosin receptor kinase: a novel target in screened neuroendocrine tumors [PDF]

Endocrine-Related Cancer, 2018
Tropomyosin receptor kinase (Trk) inhibitors are investigated as a novel targeted therapy in various cancers. We investigated thein vitroeffects of the pan-Trk inhibitor GNF-5837 in human neuroendocrine tumor (NET) cells. The human neuroendocrine pancreatic BON1, bronchopulmonary NCI-H727 and ileal GOT1 cell lines were treated with GNF-5837 alone and ...
Elke Tatjana Aristizabal Prada, Nina Schmidt, Thomas Knösel, Svenja Nölting, Günter K. Stalla, Vera Heinzle, Klaus A. Kuhn, Christoph J. Auernhammer, Gerald Spöttl, Felix Beuschlein, Felix Beuschlein, Rainer Blaser, Julian Maurer, Christine Spitzweg, Martin K. Angele   +14 more
openaire   +2 more sources

Brain‐Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Brain‐derived neurotrophic factor (BDNF) is expressed in neuronal and nonneuronal cells and may affect vascular functions via its receptor, tropomyosin‐related kinase B (TrkB).
Sarah Zierold, Katja Buschmann, Sogol Gachkar, Magdalena L. Bochenek, David Velmeden, Lukas Hobohm, Christian‐Friedrich Vahl, Katrin Schäfer   +7 more
doaj   +1 more source

Proteomic profiling of impaired excitation–contraction coupling and abnormal calcium handling in muscular dystrophy

PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022
Abstract The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is characterised by primary abnormalities in the membrane cytoskeletal component dystrophin. The almost complete absence of the Dp427‐M isoform of dystrophin in skeletal muscles renders contractile fibres more susceptible to progressive degeneration and a leaky ...
Paul Dowling, Stephen Gargan, Dieter Swandulla, Kay Ohlendieck   +3 more
wiley   +1 more source

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging [PDF]

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging. TrkA/B/C downregulation is a prominent hallmark of various neurological disorders including Alzheimer’s disease (AD). Abnormally expressed or overexpressed full-length or oncogenic fusion TrkA/
Alexey Kostikov, Björn Wängler, Andrew V. Mossine, Lena Kaiser, Esther Schirrmacher, Peter Bartenstein, Justin J. Bailey, Gert Fricker, Anne Mahringer, Carmen Wängler, Ralf Schirrmacher, Pedro Rosa-Neto, David L. Kaplan, Alexander Thiel, Alexander Thiel, Vadim Bernard-Gauthier, Vadim Bernard-Gauthier, Simon Lindner, Peter J. H. Scott, Jean-Paul Soucy   +19 more
openaire   +3 more sources

Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin [PDF]

Journal of Integrative Neuroscience, 2019
Hippocampal neurogenesis plays an important role in the onset and treatment of depressive disorders. Previous studies suggest that paeoniflorin could be used as an antidepressant for treating rats subjected to chronic unpredictable stress. In this study,
Li-Bing Chen, Feng-Mei Qiu, Xiao-Ming Zhong, Cheng Hong, Zhen Huang
doaj   +1 more source

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]

, 2016
BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I, Ellinwood, N Matthew, Esko, Jeffrey D, Gordts, Philip L, Khalid, Omar, Schwartz, Philip H, Vera, Moin U, Wang, Raymond Y   +7 more
core   +8 more sources

Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts

Scientific Reports, 2021
Constructive remodeling of focal esophageal defects with biodegradable acellular grafts relies on the ability of host progenitor cell populations to repopulate implant regions and facilitate growth of de novo functional tissue.
Gokhan Gundogdu, Mehmet Tosun, Duncan Morhardt, Ali Hashemi Gheinani, Khalid Algarrahi, Xuehui Yang, Kyle Costa, Cinthia Galvez Alegria, Rosalyn M. Adam, Wei Yang, Joshua R. Mauney   +10 more
doaj   +1 more source

Synthetic inhibitor leads of human tropomyosin receptor kinase A (hTrkA) [PDF]

RSC Medicinal Chemistry, 2020
New hTrkA kinase domain type 2 inhibitors and mixed type 1/type 2 inhibitor leads disclosed here offers a differential starting point to investigate the disease pathophysiology.
Govindan Subramanian, Rajendran Vairagoundar, Scott J. Bowen, Nicole Roush, Theresa Zachary, Christopher Javens, Tracey Williams, Ann Janssen, Andrea Gonzales   +8 more
openaire   +3 more sources

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

Possible role of tropomyosin-receptor kinase fused gene on skin collagen remodeling [PDF]

Journal of Dermatological Science, 2017
Jung‐Min Shin, So-Jung Kong, Youngah Shin, Yunhee Chang, Jiyoung Kim, Kyung‐Cheol Sohn, Young‐Joon Seo, Chang Deok Kim, Lee Jeung-Hoon, Young Lee   +9 more
openalex   +4 more sources