Results 81 to 90 of about 74,566 (254)

Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho kinase dependent pathway [PDF]

, 2016
Leptin has been implicated as a key upstream mediator of pathways associated with coronary vascular dysfunction and disease. The purpose of this investigation was to test the hypothesis that leptin modifies the coronary artery proteome and promotes ...
Goodwill, Adam G., Kiel, Alexander M., Noblet, Jillian N., Sassoon, Daniel J., Tune, Johnathan D.   +4 more
core   +3 more sources

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes [PDF]

, 2020
Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently ...
A Avogaro, A Gaultier, A Le Guelte, A Magli, AA Anderson, AE Rodríguez-Fraticelli, AJ Monteforte, B Shu, BG Seligman, C Ling, C Margadant, C Ozbayer, C Shi, C Tian, C Ung, C Vanderplanck, C Wu, D Bosnakovski, D Bosnakovski, D Karthik, D Lazzaro, DJ Mangelsdorf, DM D'Souza, DS Frankel, E Ansseau, E Ansseau, E Nilsson, EA Coon, EA Malt, EM Small, F Gragnano, F Guan, G Theocharidis, G. Said, GH Wong, GJ Berry, GJ Berry, GL Bellot, GV Gnoni, H Andersen, H Brem, HA Ramirez, I Bettahi, I Bettahi, I Chakroun, I Gottfried, IN Vial, J Thimmarayappa, J Xu, J Yan, JB Rice, JC Corton, JG Van Vranken, JS Hansen, K Blackburn, KM Popov, L Nasarre, L Tan, LA Berchtold, LE Reynolds, M Gupta, M Wight, MA Faghihi, MK Montgomery, MR Tanner, MR Tanner, N Schonrock, N Takagi, NY Yoshihito Nogusa, P Hebbar, P Rajendran, PJ Batista, PM Mannucci, RB Tajhya, RC Pink, RN Weijers, RS Kaplan, RS Kiss, S Baldari, S Barrientos, S Das, S Das, S Lambert, S Rovira-Llopis, S Roy, S Sethumadhavan, SM Weis, SS Kulkarni, SV Suryavanshi, SY Park, T Fujiwara, T Khalfaoui, T Thiruvoipati, T Wang, T-H Wang, TT Hien, V Iacobazzi, V Miragliotta, VV Sinyov, W Meng, WI Sivitz, WM Longmate, WM Longmate, X Shi, X Wang, X Xie, X Yuan, X Zhao, X Zhao, Y Cai, Y Carrier, Y Chen, Y Gu, Y Konishi, Y Liu, Y Wang, Y-T Chen, Y-Y Hsieh, Z Jiang, Z-X Meng, ZKK Lawi   +120 more
core   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

Dissociation Between Tumor Response and PTTM Progression During Entrectinib Therapy in NTRK Fusion-Positive Colon Cancer

Current Oncology
We report a rare case of pulmonary tumor thrombotic microangiopathy (PTTM) in a patient with metastatic neurotrophic tropomyosin receptor kinase (NTRK) fusion-positive transverse colon cancer who exhibited a marked radiologic and biochemical response to ...
Hideki Nagano, Shigekazu Ohyama, Atsushi Sato, Jun Igarashi, Tomoko Yamamoto, Mikiko Kobayashi   +5 more
doaj   +1 more source

Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish [PDF]

, 2010
Background Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays
Canario, Adelino V. M., Matsumura, H., Pinto, Patricia IS, Power, Deborah, Reinhardt, Richard, Terauchi, Ryohei, Thorne, Michael A. S.   +6 more
core   +5 more sources

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques

Molecules, 2018
The aim of this study was to identify new potentially active compounds for three protein targets, tropomyosin receptor kinase A (TrkA), N-methyl-d-aspartate (NMDA) receptor, and leucine-rich repeat kinase 2 (LRRK2), that are related to various ...
Larisa Ivanova, Mati Karelson, Dimitar A. Dobchev   +2 more
doaj   +1 more source

Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women [PDF]

, 2016
microRNAs (miRNAs) play an important role in cancer prognosis. They are small molecules, approximately 17–25 nucleotides in length, and their high stability in human serum supports their use as novel diagnostic biomarkers of cancer and other pathological
El Masry, Maha Rafik, Mohareb, Fady R., Motawi, Tarek Mohamed Kamal, Sadik, Nermin Abdel Hamid, Shaker, Olfat Gamil   +4 more
core   +1 more source

Inhibition of Adult Hippocampal Neurogenesis Plays a Role in Sevoflurane-Induced Cognitive Impairment in Aged Mice Through Brain-Derived Neurotrophic Factor/Tyrosine Receptor Kinase B and Neurotrophin-3/Tropomyosin Receptor Kinase C Pathways

Frontiers in Aging Neuroscience, 2022
Sevoflurane anesthesia induces cognitive impairment, which may lead to perioperative neurocognitive disorders (PND). However, the factors and molecular mechanism underlying this impairment remains unclear.
Lichi Xu, Yanjing Guo, Gong-min Wang, G. Sun, Wei-yang Sun, Jingjing Li, Xinlei Li, Jiangnan Wu, Mengyuan Zhang   +8 more
semanticscholar   +1 more source

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source