Results 151 to 160 of about 206,412 (354)

Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
This study indicates an association of abnormal HIF‐2α expression in paraspinal myoblasts and a disproportionate slow twitch muscle fiber content in the convexity of the curvature in a sub‐set of AIS subjects, suggesting HIF‐2α dysregulation as a possible risk factor for AIS. The role of HIF‐2α in paraspinal muscle function during spinal growth and its
Wai Kit Tam   +5 more
wiley   +1 more source

A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]

open access: yes, 2017
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core   +1 more source

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

open access: yesDrug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler   +4 more
wiley   +1 more source

Creating a provincial post COVID‐19 interdisciplinary clinical care network as a learning health system during the pandemic: Integrating clinical care and research

open access: yesLearning Health Systems, Volume 7, Issue 1, January 2023., 2023
Abstract Introduction Coronavirus Disease‐2019 (COVID‐19) affects multiple organ systems in the acute phase and also has long‐term sequelae. Research on the long‐term impacts of COVID‐19 is limited. The Post COVID‐19 Interdisciplinary Clinical Care Network (PC‐ICCN), conceived in July 2020, is a provincially funded resource that is modelled as a ...
Adeera Levin   +10 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

open access: yesDrug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis   +2 more
wiley   +1 more source

ECG-FM: An Open Electrocardiogram Foundation Model [PDF]

open access: yesarXiv
The electrocardiogram (ECG) is a ubiquitous diagnostic test. Conventional task-specific ECG analysis models require large numbers of expensive ECG annotations or associated labels to train. Transfer learning techniques have been shown to improve generalization and reduce reliance on labeled data.
arxiv  

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

open access: yesESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher   +3 more
wiley   +1 more source

The utility of molecularly imprinted polymers for mass spectrometric protein and proteomics analysis

open access: yesPROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022
Abstract Selective and efficient sample clean‐up is important in mass spectrometric protein‐ and proteomics analyses from biological matrices. Molecularly imprinted polymers (MIPs), polymers prepared to have tailor‐made cavities for capture of target analytes may by such represent an interesting alternative for selective clean‐up.
Trine Grønhaug Halvorsen   +1 more
wiley   +1 more source

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