Results 121 to 130 of about 6,673,815 (394)
Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management
Advanced Science, EarlyView.Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang +4 more
wiley +1 more source
PLoS ONE, 2020 TNNI3 encoding cTnI, the inhibitory subunit of the troponin complex, is the main target for mutations leading to restrictive cardiomyopathy (RCM). Here we investigate two cTnI-R170G/W amino acid replacements, identified in infantile RCM patients, which ...
Diana Cimiotti +18 more
doaj +1 more source
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, EarlyView.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
JOR SPINE, Volume 5, Issue 4, December 2022., 2022 This study indicates an association of abnormal HIF‐2α expression in paraspinal myoblasts and a disproportionate slow twitch muscle fiber content in the convexity of the curvature in a sub‐set of AIS subjects, suggesting HIF‐2α dysregulation as a possible risk factor for AIS. The role of HIF‐2α in paraspinal muscle function during spinal growth and its
Wai Kit Tam +5 more
wiley +1 more source
Relating CAT(0) cubical complexes and flag simplicial complexes [PDF]
arXiv, 2020 Given a finite CAT(0) cubical complex, we define a flag simplicial complex associated to it, called the crossing complex. We show that the crossing complex holds much of the combinatorial information of the original cubical complex: for example, hyperplanes in the cubical complex correspond to vertex links in the crossing complex, and the crossing ...
arxiv
A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]
, 2017 Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core +1 more source
Advanced Intelligent Systems, EarlyView.It is known that biomaterial properties (e.g., shape, chemistry) direct how the body reacts to implanted materials. However, what features cause specific responses is not well known. High‐throughput screening can identify instructive properties, but manual feature segmentation in large brightfield image datasets limits discovery.
Robert Owen +10 more
wiley +1 more source
Learning Health Systems, Volume 7, Issue 1, January 2023., 2023 Abstract Introduction Coronavirus Disease‐2019 (COVID‐19) affects multiple organ systems in the acute phase and also has long‐term sequelae. Research on the long‐term impacts of COVID‐19 is limited. The Post COVID‐19 Interdisciplinary Clinical Care Network (PC‐ICCN), conceived in July 2020, is a provincially funded resource that is modelled as a ...
Adeera Levin +10 more
wiley +1 more source
Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). [PDF]
, 2014 AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI.
A. de Belder +73 more
core +3 more sources
The utility of molecularly imprinted polymers for mass spectrometric protein and proteomics analysis
PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022 Abstract Selective and efficient sample clean‐up is important in mass spectrometric protein‐ and proteomics analyses from biological matrices. Molecularly imprinted polymers (MIPs), polymers prepared to have tailor‐made cavities for capture of target analytes may by such represent an interesting alternative for selective clean‐up.
Trine Grønhaug Halvorsen +1 more
wiley +1 more source